Elucidation of the mechanisms of α-linolenic acid and its derivative in the treatment of non-small cell lung cancer using network pharmacology
Yue Meng,
Yuan Liu,
Jingjing Shao
et al.
Abstract:Purpose
α-Linolenic acid (ALA) and its derivative docosahexaenoic acid (DHA) have been reported to play an anticancer role in multiple types of cancer. However, their molecular targets in treating non-small cell lung cancer (NSCLC) have not been investigated.
Methods
The common target genes of NSCLC, ALA and DHA were obtained by intersections between disease and drug databases. The common targets were imported into the STRING database to build a PPI network. The hub genes were selected in Cytoscape. GO and K… Show more
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