Elucidation of molecular pathways responsible for the accelerated wound healing induced by a novel fibrous chitin dressing

Zhong, Zibiao; Huang, Yao; Hu, Qianchao; He, Weiyang; Duan, Bo; Yan, Xiaomin; Yang, Zhen; Liang, Wenjin; Liu, Zhongzhong; Peng, Zhonghua; Wang, Yanfeng; Zhang, Lína; Ye, Qifa

doi:10.1039/c9bm00404a

Cited by 18 publications

(8 citation statements)

References 41 publications

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“…It may also accelerate hemostasis and tissue regeneration (Liu et al, 2018). The advent of nanotechnology has opened new avenues for designing innovative and efficient therapies to overcome the barriers faced by conventional therapies (Huang et al, 2018;Zhong et al, 2019;Alqahtani et al, 2020;Wang et al, 2020;Faraji et al, 2021). Thiolation of the polymers is a novel approach for improving the healing properties of polymers and alleviating associated side effects.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration

Yao

et al. 2021

Drug Delivery

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In relieving local pains, lidocaine, one of ester-type local anesthetics, has been used. To develop the lidocaine membranes of enhanced local anesthetic effects, we have designed to establish the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded chitosan (CS)/ polymyxin B sulfate (PMB). The LCH membranes (LCH-CS/PMB) was fabricated by the LCH oxide solutions within the CS/PMB matrix. The influences of different experimental limitations on CS/PMB membrane formations were examined. The double membrane particle sizes were evaluated by scanning electron microscopy (HR-SEM). Additionally, antibacterial efficacy was developed for gram-positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 16 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH-CS/ PMB-treated wound with less damaging. These findings indicate that LCH-CS/PMB-based bandaging materials could be a potential innovative biomaterial for tissue repair and regeneration for wound healing applications in an animal model.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration

Yao

et al. 2021

Drug Delivery

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“…In addition, sacchachitin nanofibers accelerated blood clotting times by 30 s and significantly promoted wound healing in streptozotocin-induced diabetic rats [223]. Interestingly, chitin accelerated wound healing via a MyD88-dependent pathway, followed by a TGF-β/Smad pathway [224]. Furthermore, Pseudomonas aeruginosa-infected wounds in db/db diabetic mice were diminished by cleaning with cleansing agent hypochlorous acid and covering with silver nanoparticle/chitin in the form of nanofiber sheet [225].…”

Section: Trauma/woundmentioning

confidence: 99%

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

Satitsri

Muanprasat

2020

Molecules

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Chitin is a long-chain polymer of N-acetyl-glucosamine, which is regularly found in the exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been known that chitin can be used for biological and biomedical applications, especially as a biomaterial for tissue repairing, encapsulating drug for drug delivery. However, chitin has been postulated as an inducer of proinflammatory cytokines and certain diseases including asthma. Likewise, chitosan, a long-chain polymer of N-acetyl-glucosamine and d-glucosamine derived from chitin deacetylation, and chitosan oligosaccharide, a short chain polymer, have been known for their potential therapeutic effects, including anti-inflammatory, antioxidant, antidiarrheal, and anti-Alzheimer effects. This review summarizes potential utilization and limitation of chitin, chitosan and chitosan oligosaccharide in a variety of diseases. Furthermore, future direction of research and development of chitin, chitosan, and chitosan oligosaccharide for biomedical applications is discussed.

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“…It is also known that a satisfactory material that covers the wound to prevent microbiological contamination and promotes a suitable environment for tissue regeneration is required for effective wound healing [10]. Hence, biomaterials such as polysaccharides (glycans) [11][12][13][14] and proteins [15,16] present an interesting alternative for this application due to their intrinsic properties that are considered essential for a dressing such as biocompatibility, non-toxicity, ability to adsorb bioactive molecules, and biodegradability [17].…”

Section: Introductionmentioning

confidence: 99%

Development of Bacterial Cellulose Biocomposites Combined with Starch and Collagen and Evaluation of Their Properties

et al. 2021

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One of the major benefits of biomedicine is the use of biocomposites as wound dressings to help improve the treatment of injuries. Therefore, the main objective of this study was to develop and characterize biocomposites based on bacterial cellulose (BC) with different concentrations of collagen and starch and characterize their thermal, morphological, mechanical, physical, and barrier properties. In total, nine samples were produced with fixed amounts of glycerol and BC and variations in the amount of collagen and starch. The water activity (0.400–0.480), water solubility (12.94–69.7%), moisture (10.75–20.60%), thickness (0.04–0.11 mm), water vapor permeability (5.59–14.06 × 10−8 g·mm/m2·h·Pa), grammage (8.91–39.58 g·cm−2), opacity (8.37–36.67 Abs 600 nm·mm−1), elongation (4.81–169.54%), and tensile strength (0.99–16.32 MPa) were evaluated and defined. In addition, scanning electron microscopy showed that adding biopolymers in the cellulose matrix made the surface compact, which also influenced the visual appearance. Thus, the performance of the biocomposites was directly influenced by their composition. The performance of the different samples obtained resulted in them having different potentials for application considering the injury type. This provides a solution for the ineffectiveness of traditional dressings, which is one of the great problems of the biomedical sector.

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Elucidation of molecular pathways responsible for the accelerated wound healing induced by a novel fibrous chitin dressing

Abstract: Fibrous chitin dressing (FCD) prepared from a NaOH-urea aqueous solution of chitin via a physical process was used to study its effect on wound healing using a full-thickness cutaneous wound model in rats and mice.

Cited by 18 publications

References 41 publications

RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration

RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

Development of Bacterial Cellulose Biocomposites Combined with Starch and Collagen and Evaluation of Their Properties

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