Elucidation of intriguing methanol-dichloromethane binary solvent mixture: Synergistic effect, analytical modeling, NMR and photo-induced electron transfer studies

D‐π‐A Molecular Probe to Unveil the Role of Solute‐Solvent Hydrogen Bonding in Solvatochromism, Location Specific Preferential Solvation and Synergistic Effect in Binary Mixtures

“…The synergistic preferential solvation observed in various BSMs in the solvation of solvatochromic probe is proposed to be due to the solvation of the probe by S 12 species, formed as a result of solvent‐solvent interaction either through hydrogen bonding or by hydrophobic interaction. This proposition first suggested by Koppel and Koppel in the studies of PS of Reichardt's betaine dye in BSM, is well established in literature corroborated by means of preferential solvation parameters f 2/1 and f 12/1 . If solvent‐solvent interaction plays key role for the synergistic behaviour, f 12/1 should be greater than f 2/1 .…”

“…Preferential or selective solvation is generally described by the molecular‐microscopic local solute‐induced inhomogeneity in a multi‐component solvent mixture and proposed to be due to the following intermolecular interactions. (i) Nonspecific solute/solvent association caused either by ‘Dielectric enrichment’ (ii) Specific solute/solvent interaction such as hydrogen‐bonding (iii) Synergistic effect due to association of both solvent components (S 1 and S 2 ) of a binary solvent mixture to form S 12 species primarily because of solvent‐solvent hydrogen bonding (iv) Solvent micro‐heterogeneity due to existence of micro‐domains such as organic solvent surrounded by water, and water solvated by organic solvent in aqueous‐organic solvent mixtures (v) Differential solvation of two different parts of the same dipolar solute by different solvent components of the mixture through molecular recognition . The above phenomena of different types of preferential solvation of a dipolar solute in a binary mixture of solvents is schematically represented in Scheme .…”

Dichloromethane replacement: towards greener chromatography via Kirkwood–Buff integrals

“…It is particularly difficult when separating very polar, heterocyclic molecules such as caffeine. DCM is an excellent solubilizer for such molecules and, when mixed with MeOH, is seen to synergistically solvate 33,34 solutes through proposed weak hydrogen and halogen bonding networks. This type of preferential solvation can increase the polarity of the binary mixture, exceeding that of both individual neat solvents, at given mole fractions.…”

“…This can be contributed to the previously proposed synergistic solvating behaviour of DCM-MeOH systems. 33,34 We can propose elucidations of the experimental results through the quantication of the KBIs for the analyte-mobile phase systems. For example, the chromatographic data for acetylsalicylic acid in MeOH modied solvent blends (Fig.…”

Ornamentation of Triskelion Peptide Nanotori to Produce Gold Nanoparticle (AuNP)‐Embedded Peptide Nanobangles

“…The fluorescence intensity of tryptophan in both peptides diminished several times over upon the gradual addition of a solution of Au III ions without affecting the shape of the fluorescence spectra (Figure B). To determine the fluorescence quenching quantitatively, the quenching constant was determined by means of the Stern–Volmer equation, F 0 / F =1+ K SV [Au III ], in which F 0 and F are the fluorescence intensity of peptide molecules in the absence and presence of the Au III ions, K SV is the fluorescence quenching constant (or Stern–Volmer constant), and [Au III ] denotes the concentration of Au III ions in solution. The obtained quenching constants ( K SV ) from the Stern–Volmer plot of peptides 1 and 2 (Figure C) revealed that the K SV values for peptides 1 and 2 were approximately 2.8×10 5 and 4.0×10 4 m −1 , respectively.…”