Elucidation of chaperone ubiquitin code in response to Huntingtin aggregation
Prajnadipta Panda,
Vivek Sarohi,
Trayambak Basak
et al.
Abstract:Huntington's disease (HD) is one of the prominent neurodegenerative diseases, characterized by the progressive decline of neuronal function, due to the accumulation and aggregation of misfolded proteins. Pathological progression of HD is hallmarked by the aberrant aggregation of the huntingtin protein (HTT) and subsequent neurotoxicity. Molecular chaperones (heat shock proteins, HSPs) play a pivotal role in maintaining proteostasis by facilitating protein refolding, degradation, or sequestration to limit the a… Show more
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