Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression

Abstract

Osteoarthritis is non-inflammatory degenerative joint arthritis, which exacerbates disability in elder persons. The molecular mechanisms of osteoarthritis are elusive. Ubiquitination, one type of post-translational modifications, has been demonstrated to accelerate or ameliorate the development and progression of osteoarthritis via targeting specific proteins for ubiquitination and determining protein stability and localization. Ubiquitination process can be reversed by a class of deubiquitinases via deubiquitination. In this review, we summarize the current knowledge regarding the multifaceted role of E3 ubiquitin ligases in the pathogenesis of osteoarthritis. We also describe the molecular insight of deubiquitinases into osteoarthritis processes. Moreover, we highlight the multiple compounds that target E3 ubiquitin ligases or deubiquitinases to influence osteoarthritis progression. We discuss the challenge and future perspectives via modulation of E3 ubiquitin ligases and deubiquitinases expression for enhancement of the therapeutic efficacy in osteoarthritis patients. We conclude that modulating ubiquitination and deubiquitination could alleviate the osteoarthritis pathogenesis to achieve the better treatment outcomes in osteoarthritis patients.

The emerging role of lncRNAs in osteoarthritis development and potential therapy

“…Genetic changes and epigenetics could involve in osteoarthritis development and progression ( Hodgkinson et al, 2022 ; Nunez-Carro et al, 2023 ; Tonutti et al, 2023 ). For example, cellular signaling pathways have been reported to regulate osteoarthritis progression ( Zhang et al, 2023a ; Ruan et al, 2023 ; Zheng et al, 2023 ). In recent years, noncoding RNAs (ncRNAs) have been revealed to participate in osteoarthritis development and progression ( Xie et al, 2020 ).…”