Elucidating the role of the gastrointestinal microbiota in racial and ethnic health disparities

Byrd, Doratha A; Carson, Tiffany L.; Williams, Faustine; Vogtmann, Emily

doi:10.1186/s13059-020-02117-w

Cited by 18 publications

(27 citation statements)

References 11 publications

(16 reference statements)

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“…This increase in animal protein-associated bacteria could perhaps contribute to the more pronounced association of animal protein intake observed in Caucasians vs. non-Caucasians. This finding again highlights the importance of an ethnic specific approach to gut microbiota research [ 52 ].…”

Section: Discussionmentioning

confidence: 82%

Protein Intake, Metabolic Status and the Gut Microbiota in Different Ethnicities: Results from Two Independent Cohorts

et al. 2021

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Background: Protein intake has been associated with the development of pre-diabetes (pre-T2D) and type 2 diabetes (T2D). The gut microbiota has the capacity to produce harmful metabolites derived from dietary protein. Furthermore, both the gut microbiota composition and metabolic status (e.g., insulin resistance) can be modulated by diet and ethnicity. However, to date most studies have predominantly focused on carbohydrate and fiber intake with regards to metabolic status and gut microbiota composition. Objectives: To determine the associations between dietary protein intake, gut microbiota composition, and metabolic status in different ethnicities. Methods: Separate cross-sectional analysis of two European cohorts (MetaCardis, n = 1759; HELIUS, n = 1528) including controls, patients with pre-T2D, and patients with T2D of Caucasian/non-Caucasian origin with nutritional data obtained from Food Frequency Questionnaires and gut microbiota composition. Results: In both cohorts, animal (but not plant) protein intake was associated with pre-T2D status and T2D status after adjustment for confounders. There was no significant association between protein intake (total, animal, or plant) with either gut microbiota alpha diversity or beta diversity, regardless of ethnicity. At the species level, we identified taxonomical signatures associated with animal protein intake that overlapped in both cohorts with different abundances according to metabolic status and ethnicity. Conclusions: Animal protein intake is associated with pre-T2D and T2D status but not with gut microbiota beta or alpha diversity, regardless of ethnicity. Gut microbial taxonomical signatures were identified, which could function as potential modulators in the association between dietary protein intake and metabolic status.

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Section: Discussionmentioning

confidence: 82%

Protein Intake, Metabolic Status and the Gut Microbiota in Different Ethnicities: Results from Two Independent Cohorts

et al. 2021

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“…However, prescribing a BA-modulating diet in an effort to reduce CRC disparities does not go far enough, as researchers must take into account the social and environmental context that drives these mechanisms ( 117 , 118 ). However, previous work examining microbial mechanisms of CRC related to diet lack population heterogeneity, limiting questions regarding structural drivers of disease ( 119 ). Dietary choices are often driven by the local food environment, and there is overwhelming evidence that those most susceptible to CRC disparities have inequitable access to high-quality food ( 120 ).…”

Section: Discussionmentioning

confidence: 99%

Bile Acids, Gut Microbes, and the Neighborhood Food Environment—a Potential Driver of Colorectal Cancer Health Disparities

et al. 2022

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“…However, these are posited to beneficially impact host-microbe interactions due to the reduction of stress-related inflammation ( 223 , 224 ). Improving safety and accessibility of public transportation, reducing harm caused by institutional racism or sexism, improving indoor and outdoor air quality, and other solutions can reduce microbial exposure inequity by removing those problems that disrupt human microbiomes and cause further harm ( 219 , 225 – 227 ).…”

Section: Microbiome-related Planning Policy and Outreachmentioning

confidence: 99%

Twenty Important Research Questions in Microbial Exposure and Social Equity

Robinson

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et al. 2022

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Elucidating the role of the gastrointestinal microbiota in racial and ethnic health disparities

Cited by 18 publications

References 11 publications

Protein Intake, Metabolic Status and the Gut Microbiota in Different Ethnicities: Results from Two Independent Cohorts

Protein Intake, Metabolic Status and the Gut Microbiota in Different Ethnicities: Results from Two Independent Cohorts

Bile Acids, Gut Microbes, and the Neighborhood Food Environment—a Potential Driver of Colorectal Cancer Health Disparities

Twenty Important Research Questions in Microbial Exposure and Social Equity

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