Elucidating the role of 45S5 bioglass content in the density and flexural strength of robocast β-TCP/45S5 composites

Galván-Chacón, Víctor Pablo; Eqtesadi, Siamak; Pajares, Antonia; Miranda, Pedro; Guiberteau, Fernando

doi:10.1016/j.ceramint.2018.04.074

Cited by 11 publications

(6 citation statements)

References 31 publications

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“…Particle size distributions were measured using laser diffraction (Cilas—1190 L), in which β‐TCP showed a mean particle size of 1.58 μm (D 10 = 0.63 μm and D 90 = 2.80 μm) and S53P4 BG of 10.34 μm (D 10 = 2.87 μm and D 90 = 18.95 μm). Both mean particle sizes were considered to be suitable for DIW processes 23 …”

Section: Methodsmentioning

confidence: 99%

“…Both mean particle sizes were considered to be suitable for DIW processes. 23 2.2 | Scaffolds 3D printing and TTO coating β-TCP and β-TCP/S53P4 BG inks were prepared using 53 wt% of solids, Pluronic F127 (Sigma-Aldrich) (20 wt%), and polyethylene glycol (PEG 400-Synth) (2.5 wt%) as additives. The amount of 7.5 wt% of S53P4 BG was chosen for β-TCP/S53P4 inks since it has been shown that this amount of bioactive glass has a positive effect on the mechanical properties and biological response of the scaffolds.…”

Section: Synthesis and Characterization Of The β-Tcp And S53p4 Bg Pow...mentioning

confidence: 99%

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3D‐printed β‐TCP/S53P4 bioactive glass scaffolds coated with tea tree oil: Coating optimization, in vitro bioactivity and antibacterial properties

et al. 2022

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Bone infection treatment is a significant challenge for the orthopedic field. 3D printing is a promising technology to produce scaffolds with customized architecture, able to stimulate and support bone growth. β-TCP and S53P4 bioactive glass (BG) are well-known biomaterials for scaffold manufacturing. However, a multifunctional scaffold, able to inhibit microbial proliferation at the defect site, is of increasing interest to avoid infection recurrence. Tea tree oil (TTO) has aroused interest as an antimicrobial agent to minimize the use of antibiotics. Therefore, combining the regenerative potential of a bioceramic with TTO's antimicrobial properties could result in a scaffold capable of stimulating tissue growth and treating infections. In this context, this study aimed to produce and characterize 3D-printed β-TCP/S53P4 BG scaffolds coated with TTO. Scaffolds morphological and chemical characterizations were carried out through XDR, SEM, and FTIR analysis. β-TCP/S53P4 BG scaffolds showed a compressive strength of $2 MPa and 53 ± 2% of porosity. The scaffolds were coated by two different procedures, using an ethanol/TTO (EtOH/TTO) and a gelatin/TTO (Gel/TTO) solution with 5, 10, and 15% (v/v) TTO. The addition of TTO decreased MG-63 cell viability for both coating groups, but the Gel/TTO group showed higher cell viability. The antibacterial activity of the coated scaffolds was evaluated against S. aureus and higher inhibition of colony formation was found for Gel/TTO group.Therefore, the coating with Gel/TTO was effective in terms of antibacterial activity and cell viability. Such Gel/TTO coated β-TCP/S53P4 BG scaffolds are proposed for antibacterial bone tissue engineering.

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Section: Methodsmentioning

confidence: 99%

Section: Synthesis and Characterization Of The β-Tcp And S53p4 Bg Pow...mentioning

confidence: 99%

3D‐printed β‐TCP/S53P4 bioactive glass scaffolds coated with tea tree oil: Coating optimization, in vitro bioactivity and antibacterial properties

et al. 2022

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“…The transformation of the β-TCP phase into α-TCP is attributed to the action of the existing silicon in the composition of the incorporated bioactive glass, which stabilizes the α-TCP phase at lower temperatures during heat treatment [43][44][45] . The observed calcium and sodium-calcium silicates, wollastonite and high-combeite, are characteristic phases of the crystallization of 45S5 BG, and also common in β-TCP/BG 45S5 composites [46][47][48][49][50] . The formation of α-TCP improves bioactivity, dissolution rate, and the ability to replace scaffolds with new bone while silicates have good mechanical strength and bioactivity 48,51,52,53 .…”

Section: Resultsmentioning

confidence: 87%

Synergistic Effect of Incorporation of BG 45S5 and Silver Nanoparticles on β-TCP Scaffolds: Structural Characterization and Evaluation of Antimicrobial Activity and Biocompatibility

et al. 2023

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Bacterial infections after implant surgical procedures are a complication observed in many surgeries to treat bone injuries or diseases. Bacteria can attach to the surface of the implant producing biofilms, and if treatment with antibiotics does not work, further surgery is necessary to remove the infected implant. Among the biomaterials for bone implants, bioceramics based on calcium phosphates (CaPs) such as β-TCP stand out, due to their chemical similarity with bone and high bioresorbability. β-TCP has the characteristic of easily accommodating in its crystalline structure reasonable amounts of doping elements, such as monovalent and trivalent ions, which makes it an efficient transporter of drugs, molecules, and therapeutic ions The objective of this work was the incorporation of bioactive glass (BG 45S5) via sol-gel and silver nanoparticles (Ag-NPs) in β-TCP scaffolds, aiming to confer antimicrobial activity to the scaffolds, without prejudice to biocompatibility. XRD and FT-IR analysis indicated structural changes after the incorporation of BG 45S5 and Ag-NPs in β-TCP scaffolds, and these compounds induced the partial transformation of the β-TCP phase into α-TCP phase and the formation of sodium-calcium silicates and silver silicates. The FT-IR spectra showed characteristic bands of α-TCP after incorporation, in addition to the predominant bands of β-TCP. Biocompatibility after incorporation of BG 45S5 was improved, with a significant increase in cell viability. After the incorporation of Ag-NPs, cell viability was maintained at an acceptable level, no cytotoxic behavior was observed, and the scaffolds showed antibacterial and antifungal activity. The results indicate that BG 45S5 and the Ag-NPs incorporated showed a synergistic behavior, conferring antimicrobial activity to the scaffolds without compromising biocompatibility, showing great potential for applicability in tissue engineering.

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“…When the 45S5 ratio increased to 70%, the 45S5 BG/β-TCP scaffold sintered at 1100 °C attained a bending strength of 110 MPa. 73 The pore size, porosity, and pore shape can be varied in precision based on the unit cell designs fabricated by the LCM technique. 74 The unit cell-based β-TCP scaffold with different porosity ranges is fabricated by the LCM technique resulting in the maximum compressive strength of 67.6 MPa for a porosity of 5.58%.…”

Section: Tricalcium Phosphatesmentioning

confidence: 99%

“…The obtained compressive strength is way higher than the individual compressive strength values obtained for β-TCP and BG fabricated by the same robocasting technique. , The density and bending strength of the BG/β-TCP scaffold continue to increase with the increase in the BG concentration. When the 45S5 ratio increased to 70%, the 45S5 BG/β-TCP scaffold sintered at 1100 °C attained a bending strength of 110 MPa …”

Section: Physical and Mechanical Characteristics Of Additive Manufact...mentioning

confidence: 99%

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

Thangavel

Elsen

2022

ACS Biomater. Sci. Eng.

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This review focuses on the advancements in additive manufacturing techniques that are utilized for fabricating bioceramic scaffolds and their characterizations leading to bone tissue regeneration. Bioscaffolds are made by mimicking the human bone structure, material composition, and properties. Calcium phosphate apatite materials are the most commonly used scaffold materials as they closely resemble live bone in their inorganic composition. The functionally graded scaffolds are fabricated by utilizing the right choice of the 3D printing method and material combinations to achieve the requirement of the bioscaffold. To tailor the physical, mechanical, and biological properties of the scaffold, certain materials are reinforced, doped, or coated to incorporate the functionality. The biomechanical loading conditions that involve flexion, torsion, and tension exerted on the implanted scaffold are discussed. The finite element analysis (FEA) technique is used to investigate the mechanical property of the scaffold before fabrication. This helps in reducing the actual number of samples used for testing. The FEA simulated results and the experimental result are compared. This review also highlights some of the challenges associated while processing the scaffold such as shrinkage, mechanical instability, cytotoxicity, and printability. In the end, the new materials that are evolved for tissue engineering applications are compiled and discussed.

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Elucidating the role of 45S5 bioglass content in the density and flexural strength of robocast β-TCP/45S5 composites

Cited by 11 publications

References 31 publications

3D‐printed β‐TCP/S53P4 bioactive glass scaffolds coated with tea tree oil: Coating optimization, in vitro bioactivity and antibacterial properties

3D‐printed β‐TCP/S53P4 bioactive glass scaffolds coated with tea tree oil: Coating optimization, in vitro bioactivity and antibacterial properties

Synergistic Effect of Incorporation of BG 45S5 and Silver Nanoparticles on β-TCP Scaffolds: Structural Characterization and Evaluation of Antimicrobial Activity and Biocompatibility

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

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