Elucidating the Mechanism by Which &lt;i&gt;Gypsum fibrosum&lt;/i&gt;, a Traditional Chinese Medicine, Maintains Cutaneous Water Content

Ikarashi, Nobutomo; Ogiue, Naoki; Toyoda, Eri; Nakamura, Michiru; Kon, Risako; Kusunoki, Yoshiki; Aburada, Takashi; Ishii, Makoto; Tanaka, Yoshikazu; Machida, Yoshiaki; Ochiai, Wataru; Sugiyama, Kiyoshi

doi:10.1248/bpb.b13-00494

Cited by 15 publications

(18 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TCM II was composed of four dried herbs; Cortex Phellodendri , Gypsum Fibrosum , Rhizoma Atractylodes , and Agastache Rugosa . Among these herbs, C. Phellodendron and G. Fibrosum play an important role on clearing heat (Lu et al, 2006; Ikarashi et al, 2013), as well as A. Rugosa and R. Atractylodes are damp-clearing medicines (Yan et al, 2006). It was also reported that the effects of these TCM decoctions in vitro enhanced the antioxidant status and reduced lipid peroxidation in heat-stressed intestinal crypt-like epithelial cells (Guo et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese Medicine Prescriptions Enhance Growth Performance of Heat Stressed Beef Cattle by Relieving Heat Stress Responses and Increasing Apparent Nutrient Digestibility

Song¹,

Luo²,

et al. 2014

Asian Australas. J. Anim. Sci

View full text Add to dashboard Cite

The present aim was to investigate the effects of traditional Chinese medicine prescriptions (TCM) on body temperature, blood physiological parameters, nutrient apparent digestibility and growth performance of beef cattle under heat stress conditions. Twenty-seven beef cattle were randomly divided into three groups as following; i) high temperature control (HTC), ii) traditional Chinese medicine prescriptions I+high temperature (TCM I) and iii) traditional Chinese medicine prescriptions II+high temperature (TCM II) (n = 9 per group). The results showed that the mean body temperature declined in TCM II treatment (p<0.05). Serum T3 and T4 levels with TCM I and TCM II treatments elevated (p<0.05), and serum cortisol levels of TCM I treatments decreased (p<0.05), compared with the HTC group. Total protein, albumin, globulin in TCM II treatments elevated and blood urea nitrogen levels of both TCM treatments increased, but glucose levels of both TCM treatments decreased, compared with the HTC group (p<0.05). The apparent digestibility of organic matter and crude protein with TCM I treatment increased, and the apparent digestibility of acid detergent fiber elevated in both TCM treatments (p<0.05). Average daily feed intake was not different among three groups, however average daily gain increased and the feed:gain ratio decreased with both TCM treatments, compared with the HTC group (p<0.05). The present results suggest that dietary supplementation with TCM I or TCM II improves growth performance of heat stressed beef cattle by relieving heat stress responses and increasing nutrient apparent digestibility.

show abstract

Section: Discussionmentioning

confidence: 99%

Traditional Chinese Medicine Prescriptions Enhance Growth Performance of Heat Stressed Beef Cattle by Relieving Heat Stress Responses and Increasing Apparent Nutrient Digestibility

Song¹,

Luo²,

et al. 2014

Asian Australas. J. Anim. Sci

View full text Add to dashboard Cite

show abstract

“…GF was clearly shown to cause an increase in the intracellular Ca 2+ concentration, PKC activity, and the phosphorylation levels of ERK and CREB, resulting in increased AQP3 expression in keratinocytes (Fig. ) . In addition, it is possible that the effect of GF is attributable to CaSO 4 , given that the mechanisms of action of GF and CaSO 4 were nearly identical.…”

Section: Mechanism Of Skin Aqp3 Expression Increase By Gypsum Fibrosummentioning

confidence: 94%

“…When GF extract was added to human keratinocytes, increased AQP3 expression, increased intracellular Ca 2+ content, elevated PKC activity, and enhanced CREB and ERK phosphorylation were observed . Moreover, it was found that the increase in AQP3 expression upon the addition of GF extract was almost completely suppressed by pretreatment with an inhibitor of PKC activation.…”

Section: Mechanism Of Skin Aqp3 Expression Increase By Gypsum Fibrosummentioning

confidence: 94%

“…GF is effective for reducing fever and inflammation and for providing sedation. The questions, however, of whether a relationship exists between these effects and the increase in skin AQP3 expression, and how CaSO 4 increases the expression of AQP3, were investigated in the Ikarashi et al study .…”

Section: Mechanism Of Skin Aqp3 Expression Increase By Gypsum Fibrosummentioning

confidence: 99%

“…We formulated and attempted to verify our hypothesis that the efficacy of BKN is exerted by controlling the expression of AQP. This review provides an overview of findings regarding the water control mechanisms of BKN and its activity with regard to AQP, with a focus on our studies .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Water control mechanism of byakkokaninjinto and its active components via aquaporins

Ikarashi

Aburada

Kon

et al. 2019

Traditional & Kampo Medicine

Self Cite

View full text Add to dashboard Cite

Objective: Byakkokaninjinto (BKN) is clinically used for conditions associated with thirst, polyuria, or cutaneous pruritus.Recently, it has also been used for improving thirst and polyuria observed in diabetes as well as pruritus associated with excessively dry skin. The aim of this study was to investigate aquaporins (AQP) in order to obtain scientific evidence regarding the mechanisms of BKN's effect. Results: Treatment with BKN in a diabetic model of KKAy mice did not affect blood glucose but reduced both water intake and urine volume. Although the AQP5 level in the salivary glands remained unchanged, the AQP2 level in the kidneys increased significantly. This suggests that BKN causes an increase in AQP2 expression in the kidney, thereby suppressing polyuria as well as the associated thirst caused by diabetes. BKN was also shown to increase the expression of AQP3 in skin, which may suppress skin dryness and improve pruritus. In addition, Gypsum fibrosum (GF), the principal component of BKN, did not affect kidney AQP2 expression but increased skin AQP3 expression. The active ingredient of GF, CaSO 4 , was also shown to increase AQP3 expression via protein kinase C activation and to enhance phosphorylation of cAMP response element-binding protein by increasing the Ca 2+ concentration in skin. Conclusion: Although there are many herbal medicines that are effective for correcting abnormal water metabolism, little is known regarding the mechanism of this activity. This study highlights the scientific basis of the effect of herbal medicines in improving water metabolism, with AQP as the primary targets.

show abstract

Eppikajutsuto (a Japanese herbal medicine) regulates mTOR and induces apoptosis in oral cancer cells

Makita

Endo

Shirai

et al. 2020

Traditional & Kampo Medicine

View full text Add to dashboard Cite

AimThe effectiveness of Japanese traditional (Kampo) medicine is gradually attracting attention worldwide. It is typically known to be effective against cancer as a supportive therapy, but the antitumor effect of Kampo formulas is not fully established. We therefore evaluated the antitumor effect of eppikajutsuto.MethodsWe evaluated the antitumor effect of eppikajutsuto by cell viability assay, western blotting, and apoptotic cell assay using an oral squamous cell carcinoma cell line OSC‐19.ResultsWe found that the administration of eppikajutsuto to OSC‐19 in vitro inhibited cell proliferation, induced apoptosis, and suppressed mTOR activation.ConclusionsThe results suggested that eppikajutsuto might exhibit antitumor effect against OSC‐19 in vitro by suppressing mTOR activation. However, additional studies in vitro and in vivo are required to confirm the antitumor effect of eppikajutsuto.

show abstract

Elucidating the Mechanism by Which <i>Gypsum fibrosum</i>, a Traditional Chinese Medicine, Maintains Cutaneous Water Content

Cited by 15 publications

References 40 publications

Traditional Chinese Medicine Prescriptions Enhance Growth Performance of Heat Stressed Beef Cattle by Relieving Heat Stress Responses and Increasing Apparent Nutrient Digestibility

Traditional Chinese Medicine Prescriptions Enhance Growth Performance of Heat Stressed Beef Cattle by Relieving Heat Stress Responses and Increasing Apparent Nutrient Digestibility

Water control mechanism of byakkokaninjinto and its active components via aquaporins

Eppikajutsuto (a Japanese herbal medicine) regulates mTOR and induces apoptosis in oral cancer cells

Contact Info

Product

Resources

About