Elucidating the Links Between Mother and Father Alcohol Use Disorder and Adolescent Externalizing Psychopathology: A Test of Transmission Specificity Within Competing Factor Structures and Genetic and Environmental Liabilities

Oro, Veronica; Goldsmith, H. Hill; Lemery‐Chalfant, Kathryn

doi:10.1007/s10519-021-10072-w

Cited by 6 publications

(12 citation statements)

References 74 publications

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“…As few across-spectra associations were found, our results corroborated the finding from the retrospective World Health Organization study that the within-spectrum associations were higher than the across-spectra associations . In contrast to the within-spectrum association found beyond the general psychopathology factor in our study, the Wisconsin Twin study found no transmission effects left for specific internalizing factor, as the transmission from parental internalizing factor to the offspring general psychopathology factor was sufficient in explaining the bivariate parent-offspring associations . This contradictory result may be attributable to the fact that the general psychopathology factor was derived from distinct individuals (parents vs offspring) and conditions were evaluated differently (by interviewers vs by specialists).…”

Section: Discussionsupporting

confidence: 85%

“…First, in a Swedish children-of-twins study (N = 854), a general psychopathology factor based on self-reported internalizing and externalizing symptoms was positively associated between parents and their offspring . Second, in a Wisconsin twin study (N = 502), a parental internalizing factor was associated with an offspring general psychopathology factor based on interviewer-assessed internalizing and externalizing problems . Nevertheless, it remains unknown whether these results might be generalizable to other forms of mental health problems (eg, psychotic disorders) in parents and associated behaviors (eg, suicide and criminal convictions) in their offspring.…”

Section: Introductionmentioning

confidence: 98%

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Intergenerational Transmission of Psychiatric Conditions and Psychiatric, Behavioral, and Psychosocial Outcomes in Offspring

Zhou,

Larsson,

D’Onofrio

et al. 2023

JAMA Netw Open

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ImportancePsychiatric conditions in parents are associated with many psychiatric and nonpsychiatric outcomes in offspring. However, it remains unknown whether this intergenerational transmission is attributable to broader psychopathology comorbidity or to specific conditions.ObjectiveTo estimate associations between general and specific psychopathology factors in parents and a wide range of register-based outcomes in their offspring.Design, Setting, and ParticipantsThis Swedish national register-based cohort study included 2 947 703 individuals born between 1970 and 2000 and followed up with participants through December 31, 2013. Statistical analysis was performed from October 2022 to October 2023.ExposuresHierarchical factor model consisting of 1 general and 3 specific psychopathology factors fit to 9 parental psychiatric diagnoses and violent criminal court convictions.Main Outcomes and MeasuresA total of 31 outcomes were measured in offspring and sorted into 6 broad clusters: psychotic-like outcomes, neurodevelopmental outcomes, internalizing outcomes, externalizing outcomes, behavior and accidents, and psychosocial outcomes.ResultsOf 2 947 703 individuals, 1 518 252 (51.5%) were male, and the mean (SD) age at the end of follow-up was 28.7 (8.9) years. The general psychopathology factor in parents was significantly associated with all 31 offspring outcomes (range: odds ratio [OR] for accidents, 1.08 [95% CI, 1.07-1.08] to OR for social welfare recipiency, 1.40 [95% CI, 1.39-1.40]), which means that children whose parents scored 1 SD above the mean on the general psychopathology factor had an 8% to 40% higher odds of different studied outcomes. The specific psychotic factor in parents was primarily associated with all 5 psychotic-like outcomes (range: OR for prescription of antiepileptics, 1.05 [95% CI, 1.04-1.06] to OR for schizophrenia, 1.25 [95% CI, 1.23-1.28]) and the specific internalizing factor in parents was primarily associated with all 6 internalizing outcomes (range: OR for prescription of anxiolytics, 1.10 [95% CI, 1.09-1.10] to OR for depression, 1.13 [95% CI, 1.12-1.13]) and all 6 neurodevelopmental outcomes (range: OR for intellectual disability, 1.02 [95% CI, 1.01-1.03] to OR for autism spectrum disorder, 1.10 [95% CI, 1.09-1.11]) in offspring. The specific externalizing factor in parents was associated with all 6 externalizing outcomes (range: OR for violent crimes, 1.21 [95% CI, 1.19-1.23] to OR for oppositional defiant disorder, 1.32 [95% CI, 1.32-1.33]) and all 6 internalizing outcomes (range: OR for obsessive-compulsive disorder, 1.01 [95% CI, 1.00-1.02] to OR for posttraumatic stress disorder, 1.13 [95% CI, 1.12-1.13]) in offspring.Conclusions and RelevanceThis cohort study of the Swedish population suggests that the intergenerational transmission of psychiatric conditions across different types of spectra may largely be attributable to a parental general psychopathology factor, whereas specific factors appeared to be primarily responsible for within-spectrum associations between parents and their offspring. Professionals who work with children (eg, child psychologists, psychiatrists, teachers, and social workers) might benefit from taking the total number of parental psychiatric conditions into account, regardless of type, when forecasting child mental health and social functions.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 98%

Intergenerational Transmission of Psychiatric Conditions and Psychiatric, Behavioral, and Psychosocial Outcomes in Offspring

Zhou,

Larsson,

D’Onofrio

et al. 2023

JAMA Netw Open

View full text Add to dashboard Cite

show abstract

“…Genetic effects on externalizing varied across levels of negative emotionality within different environments. Extending the measurement of externalizing, Oro et al (2021) examined predictors of externalizing and internalizing factors of psychopathology assessed from a clinical interview during adolescence (mean age 13), with a bifactor model best fitting the data. Externalizing and internalizing factors were heritable, with shared genetic influence, and both were influenced by the nonshared environment.…”

Section: Late Childhood and Adolescencementioning

confidence: 99%

An Introduction to the Special Issue: Developmental Behavior Genetics and Externalizing Psychopathology

Elam

DiLalla

2021

Behav Genet

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“…It was also expected that associations of parent drinking with parenting and child affect will be especially strong for parents who have greater coping or enhancement motives. However, as there are mixed findings for differences in parent drinking effects based on parent gender (e.g., Homel & Warren, 2019; Li et al, 2017; Oro et al, 2021), no differences in associations between mothers and fathers were hypothesized. Tests of interactions between mother and father drinking and drinking motives were also considered exploratory.…”

mentioning

confidence: 99%

“…Many children are exposed to parental drinking: 55% and 46% of men and women, respectively, have consumed alcohol in the past month (White, 2020). Although parental alcohol use disorder has well-established associations with child mental health issues (e.g., internalizing and externalizing symptoms; Oro et al, 2021), subclinical levels of alcohol use that are common in the general population may also have adverse effects on children. Alcohol has complex acute effects on cognition, emotion, and behavior that may lead to incidents that are detrimental to the parent-child relationship.…”

mentioning

confidence: 99%

Parental drinking and observations of parent–child problem-solving discussions: Do drinking motives matter?

Keller

Rawn

Dunsmore

et al. 2023

Journal of Family Psychology

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Alcohol is often used for emotion-regulation purposes, yet there has been little research on how emotionregulation drinking motives relate to parenting. The present study addresses this gap by investigating possible interactions between parent drinking and drinking motives in the prediction of parenting and child affectivity during a problem-solving interaction. Participants included 199 two-parent families with a child between the ages of 6 and 12 years. Mothers and fathers self-reported their drinking and drinking motivations, and each parent separately took part in a 5-min parent-child problem-solving discussion about a topic that the parent identified as a frequent source of conflict. These discussions were later coded for parent rejection and coercion and child positive and negative affectivity. Father enhancement motives were independently related to father harsh parenting and indirectly related to lower child positive affect and greater child negative affect. Mother drinking to regulate positive and negative emotions interacted with mother drinking in association with mother harsh parenting, father harsh parenting, and child positive and negative affect during father-child interactions. Although the pattern of these interactions differed, the combination of mother greater drinking and coping or enhancement motives tended to have higher harsh parenting, child positive affect, and child negative affect. These findings indicate that parents' emotionregulation motives for drinking warrant greater attention from researchers to understand the impact of parent drinking on parenting and emotional development of children.

show abstract

Elucidating the Links Between Mother and Father Alcohol Use Disorder and Adolescent Externalizing Psychopathology: A Test of Transmission Specificity Within Competing Factor Structures and Genetic and Environmental Liabilities

Cited by 6 publications

References 74 publications

Intergenerational Transmission of Psychiatric Conditions and Psychiatric, Behavioral, and Psychosocial Outcomes in Offspring

Intergenerational Transmission of Psychiatric Conditions and Psychiatric, Behavioral, and Psychosocial Outcomes in Offspring

An Introduction to the Special Issue: Developmental Behavior Genetics and Externalizing Psychopathology

Parental drinking and observations of parent–child problem-solving discussions: Do drinking motives matter?

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