Elucidating the inhibitory mechanism of yeast α-glucosidase by phytocompounds from
 Scoparia dulcis
 through
 in vitro
 and
 in silico
 approach

Murugan, Gopinath; Rajkumar, Divya Sangeetha; Kaliyaperumal, Malarvizhi; Ramdoss, Ramya; Natarajan, Sasirekha; Padmanaban, Rajashree

doi:10.1080/07391102.2022.2035820

Cited by 3 publications

(2 citation statements)

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“…Therefore, using the chemical structures of these five molecules as a template for the novel compounds, the present study aims to evaluate the binding affinity of these medications with the targeted myosin protein in the form of binding patterns. Using the workflow abstract shown in Figure 1, the following procedures are followed to create new pharmacophores and evaluate how these compounds interact with the target [3].…”

Section: Methodsmentioning

confidence: 99%

Targeted Drug Designing for Treating Masticatory Myofascial Pain Dysfunction Syndrome: An In Silico Simulation Study

Suresh,

Ramadoss,

Doble

et al. 2024

Cureus

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BackgroundMasticatory Myofascial Pain Dysfunction Syndrome (MMPDS) is a musculoligamentous disorder that shares similarities with temporomandibular joint pain and odontogenic pain. It manifests as dull or aching pain in masticatory muscles, influenced by jaw movement. Computer-aided drug design (CADD) encompasses various theoretical and computational approaches used in modern drug discovery. Molecular docking is a prominent method in CADD that facilitates the understanding of drug-bimolecular interactions for rational drug design, mechanistic studies & the formation of stable complexes with increased specificity and potential efficacy. The docking technique provides valuable insights into binding energy, free energy, and complex stability predictions.

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Section: Methodsmentioning

confidence: 99%

Targeted Drug Designing for Treating Masticatory Myofascial Pain Dysfunction Syndrome: An In Silico Simulation Study

Suresh,

Ramadoss,

Doble

et al. 2024

Cureus

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“…Scoparia dulcis L is the only plant species used in diabetes. Recent studies revealed that the extracts of Scoparia dulcis L can reduce blood glucose fasting level, increase the plasma insulin level and stimulate insulin secretion [48][49] . In the eye disease category, Commelina benghalensis L is used in eye acne treatment.…”

Section: Informant Consensus Factor (Icf)mentioning

confidence: 99%

Untitled

2022

IJPSR

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Due to plentiful wild plant diversity, poor road conditions to connect modern medical facilities, and age-old folk knowledge on medicinal plants, the tribal communities of Dhemaji District, Assam, India, still practice traditional plant-based therapy in the management of primary healthcare. The present investigation aims to represent the ethnobotanical knowledge of different ethnic community peoples of the Nilakh-Sripani area, a fringe area laying the Assam-Arunachal border. The ethnobotanical field survey (2018-2020) was carried out based on formal and informal semi-structured questionnaires with village headmen, traditional healers, and well-educated persons from 11 villages belonging to Nilakh and Sripanigaon panchayat. Analysis of the demographic profile of informants, local names of plants, parts used, used in ailments, preparation and route of administration was investigated during the survey. The documented data were also quantitatively analyzed by using standard ethnobotanical parameters like Use Value (UV), Fidelity Level (FL) and Informant Consensus Factor (ICF). A total of 102 plant species belonging to 57 families were recorded. During the time of the study, 33 plant species having new ethnobotanical potential were recorded. Besides the uses of plant species in different human ailment categories, 8 plant species are reported in managing livestock diseases especially in poultries, pigs and cattle, and 2 species used as a bio-pesticide in the study area. The study further should be helpful for the valid discovery of a new active pharmaceutical ingredient (API) or drug formulation from natural origin. INTRODUCTION:In India, different tribal community people use more than 8000 medicinal plant species and approximately 25,000 folk medicine-based formulations of their traditional healthcare system 1 . The majority tribal community peoples of entire North-East India, i.e., more than 200 tribes of different ethnic groups, are inhabited in the forest ecosystem and have their sociocultural patterns, tradition, and specific food habits 2 .

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Review on the pharmacological effects and pharmacokinetics of scutellarein

Lai,

2024

Archiv der Pharmazie

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Scutellarein is a flavonoid from Scutellaria baicalensis Georgi that has been shown to have a variety of pharmacological activities. This review aims to summarize the pharmacological and pharmacokinetic studies on scutellarein and provide useful information for relevant scholars. Pharmacological studies indicate that scutellarein possesses a diverse range of pharmacological properties, including but not limited to anti‐inflammatory, antioxidant, antiviral, neuroprotective, hypoglycemic, hypolipidemic, anticancer, and cardiovascular protective effects. Further investigation reveals that the pharmacological effects of scutellarein are driven by multiple mechanisms. These mechanisms encompass the scavenging of free radicals, inhibition of the activation of inflammatory signaling pathways and expression of inflammatory mediators, inhibition of the activity of crucial viral proteins, suppression of gluconeogenesis, amelioration of insulin resistance, improvement of cerebral ischemia‐reperfusion injury, induction of apoptosis in cancer cells, and prevention of myocardial hypertrophy, among others. In summary, these pharmacological studies suggest that scutellarein holds promise for the treatment of various diseases. It is imperative to conduct clinical studies to further elucidate the therapeutic effects of scutellarein. However, it is worth noting that studies on the pharmacokinetics reveal an inhibitory effect of scutellarein on uridine 5′‐diphosphate glucuronide transferases and cytochrome P450 enzymes, potentially posing safety risks.

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Elucidating the inhibitory mechanism of yeast α-glucosidase by phytocompounds from Scoparia dulcis through in vitro and in silico approach

Cited by 3 publications

References 42 publications

Targeted Drug Designing for Treating Masticatory Myofascial Pain Dysfunction Syndrome: An In Silico Simulation Study

Targeted Drug Designing for Treating Masticatory Myofascial Pain Dysfunction Syndrome: An In Silico Simulation Study

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Review on the pharmacological effects and pharmacokinetics of scutellarein

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