Elucidating the functional role of human ABHD16B lipase in regulating triacylglycerol mobilization and membrane lipid synthesis in Saccharomyces cerevisiae

Narayanasamy, Raja; Usharani, Dandamudi; Rajasekharan, Ram

doi:10.1016/j.chemphyslip.2023.105353

Cited by 1 publication

(1 citation statement)

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“…Finally, the biochemical characterization of a distant orthologue of ABHD16A, human ABHD16B, has been recently reported. , Like ABHD16A, this protein also shows PS-selective phospholipase activity, albeit the PLA1-type. However, not much is known about the expression or activity of ABHD16B in mammalian cells and tissues, and follow up studies are much needed to explore the existence and functions of this protein in the coming years.…”

Section: Enzymes Metabolizing Lyso-pss In Mammalian Cells and Tissuesmentioning

confidence: 98%

Lysophosphatidylserine: A Signaling Lipid with Implications in Human Diseases

Chakraborty,

Kamat

2024

Chem. Rev.

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Lysophosphatidylserine (lyso-PS) has emerged as yet another important signaling lysophospholipid in mammals, and deregulation in its metabolism has been directly linked to an array of human autoimmune and neurological disorders. It has an indispensable role in several biological processes in humans, and therefore, cellular concentrations of lyso-PS are tightly regulated to ensure optimal signaling and functioning in physiological settings. Given its biological importance, the past two decades have seen an explosion in the available literature toward our understanding of diverse aspects of lyso-PS metabolism and signaling and its association with human diseases. In this Review, we aim to comprehensively summarize different aspects of lyso-PS, such as its structure, biodistribution, chemical synthesis, and SAR studies with some synthetic analogs. From a biochemical perspective, we provide an exhaustive coverage of the diverse biological activities modulated by lyso-PSs, such as its metabolism and the receptors that respond to them in humans. We also briefly discuss the human diseases associated with aberrant lyso-PS metabolism and signaling and posit some future directions that may advance our understanding of lyso-PS-mediated mammalian physiology.

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Section: Enzymes Metabolizing Lyso-pss In Mammalian Cells and Tissuesmentioning

confidence: 98%