Elucidating the effects of microbubble pinch‐off dynamics on mammalian cell viability
Oliver McRae,
Peter L. L. Walls,
Venkatesh Natarajan
et al.
Abstract:In the biotechnology industry, ensuring the health and viability of mammalian cells, especially Chinese Hamster Ovary (CHO) cells, plays a significant role in the successful production of therapeutic agents. These cells are typically cultivated in aerated bioreactors, where they encounter fluid stressors from rapidly deforming bubbles. These stressors can disrupt essential biological processes and potentially lead to cell death. However, the impact of these transient, elevated stressors on cell viability remai… Show more
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