Elucidating the Degradation Pathways of Human Insulin in the Solid State
Andrew Fagan,
Lorraine M. Bateman,
Joseph P. O’Shea
et al.
Abstract:While there have been significant advances in the development of peptide oral dosage forms in recent years, highlighted by the clinical and commercial success of approved peptides such as Rybelsus®, there remain several barriers in the way of broad range applicability of this approach to peptide delivery. One such barrier includes the poor physical and chemical stability inherent to their structures, which persists in the solid state although degradation typically occurs at different rates and via different pa… Show more
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