Elucidating the associations between sleep disturbance and depression, fatigue, and pain in older adults with cancer

Loh, Kah Poh; Zittel, Jason; Kadambi, Sindhuja; Pandya, Chintan; Xu, Huiwen; Flannery, Marie; Magnuson, Allison; Bautista, Javier; McHugh, Colin; Mustian, Karen M.; Dale, William; Duberstein, Paul R.; Mohile, Supriya G.

doi:10.1016/j.jgo.2018.02.006

Cited by 46 publications

(34 citation statements)

References 28 publications

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“…Sleep disturbance is prevalent, and depression, fatigue, or pain are often coexisting symptoms in sleep disturbance among older patients with hematologic malignancies. Fatigue was significantly associated with sleep disturbance, and future research should explore interventions targeting sleep disturbance and fatigue [15].…”

Section: Discussionmentioning

confidence: 99%

Depression, anxiety and stress among patients with hematological malignancies and the association with quality of life: a cross-sectional study

Papathanasiou

Kelepouris

Valari

et al. 2020

Medicine and Pharmacy Reports

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Αim. To evaluate psychological distress and quality of life of patients with hematological malignancies, as well as to identify the prognostic factors that aggravate their condition. Methods. A cross-sectional, descriptive study including 87 patients with Hematological Malignancies was conducted. Data were collected with an anonymous questionnaire consisted by A) a sheet with socio-demographic characteristics, B) the Depression, Stress and Stress Scale (DASS21), and C) World Health Organization Life Quality Scale (WHOQOL - BREF30). The processing and statistical analysis of the empirical material of the research were done using the SPSS (Statistical Package for Social Science) 22.0. Results. The results showed that the age of the sample averaged 71.22 years (SD = 8.71). Regarding their marital status, single mothers were 9.2%, married 62.1%. With regard to disease-related features, 28.7% of patients had Hodgkin's Lymphoma, 27.6% Chronic Lymphocytic Leukemia, 27.6% MDL and 16.1% of patients had myelodysplastic syndrome Multiple myeloma. In the investigation of the relationship between the Mental health Scale and the Quality of Life, negative correlations of Depression, Stress, Stress and the total DAS Scale with all dimensions of Patient Quality of Life were found. Conclusions. Higher levels of psychological distress and poor mental health are associated with a low level of quality of life.

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Section: Discussionmentioning

confidence: 99%

Depression, anxiety and stress among patients with hematological malignancies and the association with quality of life: a cross-sectional study

Papathanasiou

Kelepouris

Valari

et al. 2020

Medicine and Pharmacy Reports

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“…The modified satisfaction survey consisted of 6 items, and patients and their caregivers (if available) rated each question on a 5-point Likert scale, with a total score of 30 and a higher score indicating greater satisfaction [ 39 ]. Symptom burden was assessed using a clinical symptom inventory [ 40 ]. Patients were asked to rate the severity of 11 symptoms (eg, pain, nausea, disturbed sleep) at its worst in the past week from 0 (not present) to 10 (as bad as you can imagine).…”

Section: Methodsmentioning

confidence: 99%

Novel mHealth App to Deliver Geriatric Assessment-Driven Interventions for Older Adults With Cancer: Pilot Feasibility and Usability Study

et al. 2018

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BackgroundOlder patients with cancer are at an increased risk of adverse outcomes. A geriatric assessment (GA) is a compilation of reliable and validated tools to assess domains that are predictors of morbidity and mortality, and it can be used to guide interventions. However, the implementation of GA and GA-driven interventions is low due to resource and time limitations. GA-driven interventions delivered through a mobile app may support the complex needs of older patients with cancer and their caregivers.ObjectiveWe aimed to evaluate the feasibility and usability of a novel app (TouchStream) and to identify barriers to its use. As an exploratory aim, we gathered preliminary data on symptom burden, health care utilization, and satisfaction.MethodsIn a single-site pilot study, we included patients aged ≥65 years undergoing treatment for systemic cancer and their caregivers. TouchStream consists of a mobile app and a Web portal. Patients underwent a GA at baseline with the study team (on paper), and the results were used to guide interventions delivered through the app. A tablet preloaded with the app was provided for use at home for 4 weeks. Feasibility metrics included usability (system usability scale of >68 is considered above average), recruitment, retention (number of subjects consented who completed postintervention assessments), and percentage of days subjects used the app. For the last 8 patients, we assessed their symptom burden (severity and interference with 17-items scored from 0-10 where a higher score indicates worse symptoms) using a clinical symptom inventory, health care utilization from the electronic medical records, and satisfaction (6 items scored on a 5-point Likert Scale for both patients and caregivers where a higher score indicates higher satisfaction) using a modified satisfaction survey. Barriers to use were elicited through interviews.ResultsA total of 18 patients (mean age 76.8, range 68-87) and 13 caregivers (mean age 69.8, range 38-81) completed the baseline assessment. Recruitment and retention rates were 67% and 80%, respectively. The mean SUS score was 74.0 for patients and 72.2 for caregivers. Mean percentage of days the TouchStream app was used was 78.7%. Mean symptom severity and interference scores were 1.6 and 2.8 at preintervention, and 0.9 and 1.5 at postintervention, respectively. There was a total of 27 clinic calls during the intervention period and 15 during the postintervention period (week 5-8). One patient was hospitalized during the intervention period (week 1-4) and two patients during the postintervention period (week 5-8). Mean satisfaction scores of patients and caregivers with the mobile app were 20.4 and 23.4, respectively. Barriers fell into 3 themes: general experience, design, and functionality.ConclusionsTouchStream is feasible and usable for older patients on cancer treatment and their caregivers. Future studies should evaluate the effects of the TouchStream on symptoms and health care utilization in a randomized fashion.

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“…Likewise, anxious preoccupation has been associated with depression and insomnia [2]. Similarly, depression is also common in oncological patients and can aggravate sleep disturbances [3] and together can contribute to anxious preoccupation, a coping strategy deemed inappropriate [4].…”

Section: Introductionmentioning

confidence: 99%

Incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer: data from NEOcoping study

et al. 2019

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Background Our study analyzes the incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer. Methods A multi-institutional, prospective, observational study was conducted with 750 participants of 14 hospitals in Spain. Participants' socio-demographic and clinical characteristics were collected using a standardized self-report form and using EORTC QoL-QLQ-C30, BSI, Mini-MAC questionnaires. Results In women, sleep problems, depression and anxious preoccupation were observed in 65, 41 and 21%, respectively. In men, sleep problems, depression and anxious preoccupation were reported in 51, 29 and 61%, respectively. More sleep problems, depression and anxious preoccupation were found among women than males. Depression was a significant predictor of anxious preoccupation. In males, sleep problems partially mediated this association. This was not confirmed in women. Conclusion Our findings point toward the importance of developing interventions that decrease depression and sleep problems in cancer.

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Elucidating the associations between sleep disturbance and depression, fatigue, and pain in older adults with cancer

Cited by 46 publications

References 28 publications

Depression, anxiety and stress among patients with hematological malignancies and the association with quality of life: a cross-sectional study

Depression, anxiety and stress among patients with hematological malignancies and the association with quality of life: a cross-sectional study

Novel mHealth App to Deliver Geriatric Assessment-Driven Interventions for Older Adults With Cancer: Pilot Feasibility and Usability Study

Incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer: data from NEOcoping study

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