Elucidating the anti-melanoma effect and mechanisms of Hispolon

Saqr, Ahmed Al; Majrashi, Mohammed; Alrbyawi, Hamad; Govindarajulu, Manoj; Fujihashi, Ayaka; Gottumukkala, Subbaraju; Poudel, Ishwor; Arnold, Robert D.; Babu, R. Jayachandra; Dhanasekaran, Muralikrishnan

doi:10.1016/j.lfs.2020.117702

Cited by 14 publications

(10 citation statements)

References 31 publications

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“…AC-YVAD-AMC (10 µM) was used as a substrate, and the product was measured at 360 nm/460 nm. The ICE-1 activity in the vehicle-treated control and cannabinoid-treated supernatants was expressed as relative fluorescence intensity (RFU)/mg protein [37,38].…”

Section: Nadh Contentmentioning

confidence: 99%

Effects of Cannabidiol, ∆9-Tetrahydrocannabinol, and WIN 55-212-22 on the Viability of Canine and Human Non-Hodgkin Lymphoma Cell Lines

Omer,

Pathak,

Mansour

et al. 2024

Biomolecules

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In our previous study, we demonstrated the impact of overexpression of CB1 and CB2 cannabinoid receptors and the inhibitory effect of endocannabinoids (2-arachidonoylglycerol (2-AG) and Anandamide (AEA)) on canine (Canis lupus familiaris) and human (Homo sapiens) non-Hodgkin lymphoma (NHL) cell lines’ viability compared to cells treated with a vehicle. The purpose of this study was to demonstrate the anti-cancer effects of the phytocannabinoids, cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC), and the synthetic cannabinoid WIN 55-212-22 (WIN) in canine and human lymphoma cell lines and to compare their inhibitory effect to that of endocannabinoids. We used malignant canine B-cell lymphoma (BCL) (1771 and CLB-L1) and T-cell lymphoma (TCL) (CL-1) cell lines, and human BCL cell line (RAMOS). Our cell viability assay results demonstrated, compared to the controls, a biphasic effect (concentration range from 0.5 μM to 50 μM) with a significant reduction in cancer viability for both phytocannabinoids and the synthetic cannabinoid. However, the decrease in cell viability in the TCL CL-1 line was limited to CBD. The results of the biochemical analysis using the 1771 BCL cell line revealed a significant increase in markers of oxidative stress, inflammation, and apoptosis, and a decrease in markers of mitochondrial function in cells treated with the exogenous cannabinoids compared to the control. Based on the IC50 values, CBD was the most potent phytocannabinoid in reducing lymphoma cell viability in 1771, Ramos, and CL-1. Previously, we demonstrated the endocannabinoid AEA to be more potent than 2-AG. Our study suggests that future studies should use CBD and AEA for further cannabinoid testing as they might reduce tumor burden in malignant NHL of canines and humans.

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Section: Nadh Contentmentioning

confidence: 99%

Effects of Cannabidiol, ∆9-Tetrahydrocannabinol, and WIN 55-212-22 on the Viability of Canine and Human Non-Hodgkin Lymphoma Cell Lines

Omer,

Pathak,

Mansour

et al. 2024

Biomolecules

Self Cite

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“…In addition to these compounds, genistein, a predominant isoflavonoid commonly originating from legumes and dentate plants, was suggested to have the ability to block the Janus-activated kinase 1/2 (JAK1/2)-signal transduction and the signal transducer and activator of transcription 3 (STAT3) signaling pathways in esophageal carcinoma cells by suppressing the expression of epidermal growth factor receptor (EGFR), which finally leads to the inhibition of cell proliferation and cell cycle arrest [ 46 ]. Hispolon is a natural polyphenolic compound usually derived from the traditional medicinal mushroom phellinus linteus [ 61 ]. Some researchers have demonstrated that hispolon can induce cell cycle arrest in various cancers [ 62 ].…”

Section: Overview Of Anti-cancer Properties and Involved Mechanisms O...mentioning

confidence: 99%

Nano-Based Drug Delivery of Polyphenolic Compounds for Cancer Treatment: Progress, Opportunities, and Challenges

Jia

Zhou

et al. 2023

Pharmaceuticals

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Polyphenols and their derivates, a kind of natural product distributed in herb plants, vegetables, and fruits, are the most abundant antioxidants in the human diet and have been found to display cancer-preventative effects in several epidemiological studies. The scientific community has also validated the anti-cancer bioactivities and low toxicities of polyphenolic compounds, including flavones, tannins, phenolic acids, and anthocyanins, through in vitro and in vivo studies. However, the low stability, weak targeting ability, poor solubility, and low bioavailability of pure polyphenolic agents have significantly impaired their treatment efficacy. Nowadays, nano-based technology has been applied to surmount these restrictions and maximize the treatment efficacy of polyphenols. In this review, we summarize the advantages and related mechanisms of polyphenols in cancer treatment. Moreover, aiming at the poor solubility and low bioavailability of pure polyphenols in vivo, the advantages of nano-based delivery systems and recent research developments are highlighted. Herein, particular emphasis is mainly placed on the most widely used nanomaterials in the delivery of natural products, including liposomes, micelles, and nanogels. Finally, we present an overview and the challenges of future implementations of nano-based delivery systems of polyphenolic compounds in the cancer therapeutic field.

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“…Hispolon attenuated STAT3 signaling, and also induced S-phase arrest and mitochondriadependent apoptosis in prostate cancer cells [464]. In melanoma cells, it compromised the activities of mitochondrial respiration complexes I and IV, i.e., the level of Bcl-2, and also increased ROS, nitrite, and lipid peroxide levels [465]. Regarding breast cancer, hispolon, on the contrary, attenuated ROS levels, ERK activity, and the expression of Slug, therefore reversing EMT (Zhao 2016).…”

Section: Mushroomsmentioning

confidence: 99%

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

et al. 2022

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Traditional herbal medicine (THM) is a “core” from which modern medicine has evolved over time. Besides this, one third of people worldwide have no access to modern medicine and rely only on traditional medicine. To date, drugs of plant origin, or their derivates (paclitaxel, vinblastine, vincristine, vinorelbine, etoposide, camptothecin, topotecan, irinotecan, and omacetaxine), are very important in the therapy of malignancies and they are included in most chemotherapeutic regimes. To date, 391,000 plant and 14,000 mushroom species exist. Their medical and biochemical capabilities have not been studied in detail. In this review, we systematized the information about plants and mushrooms, as well as their active compounds with antitumor properties. Plants and mushrooms are divided based on the regions where they are used in ethnomedicine to treat malignancies. The majority of their active compounds with antineoplastic properties and mechanisms of action are described. Furthermore, on the basis of the available information, we divided them into two priority groups for research and for their potential of use in antitumor therapy. As there are many prerequisites and some examples how THM helps and strengthens modern medicine, finally, we discuss the positive points of THM and the management required to transform and integrate THM into the modern medicine practice.

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Elucidating the anti-melanoma effect and mechanisms of Hispolon

Cited by 14 publications

References 31 publications

Effects of Cannabidiol, ∆9-Tetrahydrocannabinol, and WIN 55-212-22 on the Viability of Canine and Human Non-Hodgkin Lymphoma Cell Lines

Effects of Cannabidiol, ∆9-Tetrahydrocannabinol, and WIN 55-212-22 on the Viability of Canine and Human Non-Hodgkin Lymphoma Cell Lines

Nano-Based Drug Delivery of Polyphenolic Compounds for Cancer Treatment: Progress, Opportunities, and Challenges

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

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