Elucidating effects of single and multiple resistance mechanisms on bacterial response to meropenem by quantitative and systems pharmacology modeling and population genomics
Dominika T Fuhs,
Sara Cortés-Lara,
Jessica R Tait
et al.
Abstract:Meropenem is commonly used againstPseudomonas aeruginosa; however, resistance is emerging. Traditionally, the time unbound antibiotic concentration exceeds the MIC (fT>MIC) is used to select carbapenem regimens. We aimed to 1) characterize the effects of different resistance mechanisms on bacterial killing and resistance emergence, 2) evaluate whetherfT>MICcan predict these effects, and 3) develop a novel quantitative and systems pharmacology model to elucidate effects of baseline resistance mechanisms o… Show more
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