Elucidating Compound Mechanism of Action and Polypharmacology with a Large-scale Perturbational Profile Compendium
Lucas ZhongMing Hu,
Eugene Douglass,
Mikko Turunen
et al.
Abstract:The Mechanism of Action (MoA) of a drug is generally represented as a small, non-tissue-specific repertoire of high-affinity binding targets. Yet, drug activity and polypharmacology are increasingly associated with a broad range of off-target and tissue-specific effector proteins. To address this challenge, we have implemented an efficient integrative experimental and computational framework leveraging the systematic generation and analysis of drug perturbational profiles representing >700 FDA-approved and … Show more
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