Elraglusib induces cytotoxicity via direct microtubule destabilisation independently of GSK3 inhibition
Josh T. Coats,
Shuyu Li,
Tomoyuki U. Tanaka
et al.
Abstract:Elraglusib (9-ING-41) is an ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK3) with pre-clinical studies demonstrating broad activity against many tumour types. Promising early-phase clinical trial data led to FDA orphan drug status, and a randomised phase 2 study in combination with cytotoxic chemotherapy in pancreatic cancer has recently completed its recruitment. Similarly, single-agent responses in adult T-cell leukaemia/lymphoma and melanoma, and combination treatment data in several other tum… Show more
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