Ellagic acid reduced nicotine induced withdrawal syndrome in mice

Pérez-Pasten, Ricardo; Atitlán-Gil, Alfonso; Zuñiga-Pérez, Clara; Filardo-Kestrupp, Santiago; Otazo-Sánchez, Ma. Elena; Madrigal-Santillán, Osiris; Chamorro-Cavallos, Germán

doi:10.1016/j.toxlet.2009.06.360

Cited by 1 publication

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“…Ellagitannins have antidepressant, antiinflammatory, and analgesic properties, as well (11)(12)(13). Several studies showed that ellagic acid is useful for the treatment of colitis, Alzheimer's disease, Parkinson's disease, and anxiety and it can reduce the symptoms of nicotine dependence (14)(15)(16)(17)(18). In addition, ellagic acid has a protective effect on liver toxicity induced by carbon tetrachloride (19).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Ellagic Acid on Maximal Electroshock and Pentylenetetrazole-Induced Seizures in Mice

Khazaei

Mansouri

Siahpoosh

et al. 2019

Jundishapur J Nat Pharm Prod

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Background: Epilepsy is a series of disorders in the central nervous system defined by disruption and abnormality in the electrical activity of the brain. The mechanisms of epilepsy occurrence are not fully determined and the current pharmacological therapeutics have low efficacy and are associated with adverse reactions due to narrow therapeutic indices. Ellagic acid has neuroprotective and antioxidant effects and increases the brain's GABA levels. Objectives: This study was designed to evaluate the effects of ellagic acid on both maximal electroshock and pentylenetetrazole models of acute seizures in mice. Methods: Ellagic acid was administered at the doses of 25, 50, and 100 mg/kg in the two models of seizures. Results: The results showed that ellagic acid was effective at the lowest dose in the maximal electroshock-induced seizure in mice and the duration of hind limb tonic extension (HLTE) was significantly shorter in this group than in the untreated convulsive group. In the pentylenetetrazole convulsion model, ellagic acid significantly increased the latency to convulsion and Straub tail response. The latencies with ellagic acid were longer in groups treated with ellagic acid 25 mg/kg than with ellagic acid 50 and 100 mg/kg. Conclusions: In conclusion, it seems that ellagic acid has anticonvulsant effects in electroshock and pentylenetetrazole models of convulsion but its effects are attenuated or eliminated at higher doses.

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