Ellagic acid protects hepatocytes from damage by inhibiting mitochondrial production of reactive oxygen species

Hwang, Jung Me; Cho, Jin Sook; Kim, Tae Hyeon; Lee, Young Ik

doi:10.1016/j.biopha.2009.06.013

Cited by 53 publications

(35 citation statements)

References 12 publications

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“…The exact mechanism of this action of ellagic acid against caspase expression is not clear. Hwang et al recently reported that ellagic acid can prevent physiological and morphological signs of experimentally induced cell necrosis and apoptosis and the protection afforded by ellagic acid was consistent with its antioxidant activity [34].…”

Section: Discussionmentioning

confidence: 76%

Mechanistic Clues in the Protective Effect of Ellagic Acid Against Apoptosis and Decreased Mitochondrial Respiratory Enzyme Activities in Myocardial Infarcted Rats

Maharajan

Quine²

2011

Cardiovasc Toxicol

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Our previous study described the cardioprotective effects of ellagic acid in an isoproterenol-induced myocardial infarction model. In this study, we are reporting the mechanism of protective action of ellagic acid with respect to apoptosis and mitochondrial respiratory enzymes. Ellagic acid (7.5 and 15 mg/kg) was administered orally as a pretreatment for 10 days. Then, isoproterenol (100 mg/kg) was injected subcutaneously to rats at an interval of 24 h for 2 days. Myocardial infarction was quantified by planimetry. Apoptosis was measured by apoptotic gene expressions. The levels of mitochondrial respiratory enzymes were also measured. Isoproterenol-induced myocardial infarcted rats showed increased infarct size, a decrease in myocardial expression of the Bcl-2 gene and an increase in myocardial expression of the BAX gene. Fas ligand and caspases were markedly elevated along with compromised respiratory marker enzymes in isoproterenol-induced rats. Ellagic acid pretreatment reduced the infarct size, regulated apoptotic gene expressions and enhanced the activities of mitochondrial respiratory marker enzymes and cell viability, thereby protecting the myocardium against isoproterenol-induced myocardial infarction. The decreased infarct size associated with inhibited apoptosis and increased respiratory marker enzymes provide insight on the role of ellagic acid in antiapoptotic mechanism, and it may be the reason for its cardioprotective activity.

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Section: Discussionmentioning

confidence: 76%

Mechanistic Clues in the Protective Effect of Ellagic Acid Against Apoptosis and Decreased Mitochondrial Respiratory Enzyme Activities in Myocardial Infarcted Rats

Maharajan

Quine²

2011

Cardiovasc Toxicol

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“…As hydrolyzable tannins easily undergo hydrolysis in the gastrointestinal tract (Clifford and Scalbert, 2000;Cerdá et al, 2005), its actual bioavailability could be quite substantial. EA is an important natural compound whose potent antioxidant properties may be benefi- (Khanduja et al, 1999;Hwang et al, 2010;Kannan and Quine, 2012). The high content of this compound in the investigated plants may have a significant effect on their biological activity.…”

Section: Resultsmentioning

confidence: 99%

Quantitative Determination of Ellagic Acid and Gallic Acid in Geum Rivale L. and G. Urbanum L.

Owczarek¹,

Olszewska²,

Gudej³

2015

Acta Biologica Cracoviensia S. Botanica

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Hydrolyzable tannins and products of their hydrolysis, ellagic acid (EA) and gallic acid (GA), are important constituents of many medicinal plants and exhibit various biological activities. Geum rivale and G. urbanum are traditional herbal remedies rich in tannin compounds. The aim of the study was to quantitate free and total EA and GA in aerial and underground parts of G. rivale and G. urbanum. After optimization of extraction, both compounds were quantitated by reversed phase HPLC (RP-HPLC). EA was more abundant than GA in the investigated material, and underground parts of G. rivale were the richest source of total EA and GA.K Ke ey y w wo or rd ds s: : Geum rivale, Geum urbanum, phenolic acid, Rosaceae.

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“…Gallic acid and its derivatives have also been found in many phytomedicines with a number of biological and pharmacological activities, including scavenging of free radicals, such as HO ÅÀ (Dwibedy, Dey, Naik, Kishore, & Moorthy, 1999), inducing apoptosis of cancer cells (Saeki et al, 2000). According to Hwang, Cho, Kim, and Lee (2010), ellagic acid exhibits protective properties against oxidative stress-induced hepatocyte damage by preventing vitamin k3-induced ROS production, apoptotic and necrotic cellular damage and mitochondrial depolarization, which is a main cause of ROS production. Moreover, the antioxidant activity (TEAC) of C. villosum pulp was reported to present the highest value among other 18 tropical fruits (Barreto et al, 2009).…”

Section: åàmentioning

confidence: 99%

The potential of extracts of Caryocar villosum pulp to scavenge reactive oxygen and nitrogen species

et al. 2012

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Ellagic acid protects hepatocytes from damage by inhibiting mitochondrial production of reactive oxygen species

Cited by 53 publications

References 12 publications

Mechanistic Clues in the Protective Effect of Ellagic Acid Against Apoptosis and Decreased Mitochondrial Respiratory Enzyme Activities in Myocardial Infarcted Rats

Mechanistic Clues in the Protective Effect of Ellagic Acid Against Apoptosis and Decreased Mitochondrial Respiratory Enzyme Activities in Myocardial Infarcted Rats

Quantitative Determination of Ellagic Acid and Gallic Acid in Geum Rivale L. and G. Urbanum L.

The potential of extracts of Caryocar villosum pulp to scavenge reactive oxygen and nitrogen species

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