Ellagic acid nanoparticles attenuate oxidative stress and testicular damage in high fat Diet/Streptozotocin-Induced diabetic rats

Harakeh, Steve; Qari, Mohammed H.; Rajeh, Nisreen; Ali, Soad Shaker; El-Shitany, Nagla A.; Hassan, Saber; Abd-Allah, Elham A.; Tashkandi, Hanaa; Malik, Muhammad Ehsan; Aljabri, Feras Khaled; Azhar, Leena E; Azhar, Najiah; Al-Jaouni, Soad; Almehmadi, Yousef; Alamri, Turki; Mousa, Shaker A.

doi:10.1016/j.jksus.2021.101720

Cited by 10 publications

(3 citation statements)

References 34 publications

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“…The antioxidant compounds in pomegranate include anthocyanins and ellagic acid [ 89 , 90 , 91 ], which ameliorate oxidative stress in diabetes. A few studies suggest that anthocyanins, ellagic acid, and PU mediate pomegranate’s anti-oxidative stress effects by degrading and scavenging free radicals [ 42 , 92 , 93 , 94 , 95 , 96 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical and Clinical Studies

et al. 2023

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Diabetes mellitus is recognized as the leading contributor to cardiovascular disease and associated mortality rates worldwide. Despite the use of pharmaceutical drugs to treat diabetes, its prevalence continues to rise alarmingly. Therefore, exploring remedies with a lower toxicity profile is crucial while remaining safe and effective in addressing this global public health crisis. Punica granatum Linn (pomegranate), known for its properties and safety profile, has been investigated in applied research and preclinical and clinical trials. However, conflicting reports still exist regarding its effects in diabetes. According to our knowledge, no systematic review has been conducted to critically analyze evidence from preclinical and clinical trials simultaneously, explicitly focusing on oxidative stress, inflammation, and endothelial function in diabetes. Therefore, in this systematic review, we searched for evidence on the impact of pomegranate in diabetes using databases such as PubMed, Scopus, and Google Scholar. Our inclusion criteria were limited to studies published in English. Of the 170 retrieved studies, 46 were deemed relevant and underwent critical analysis. The analyzed evidence suggests that pomegranate has the potential to alleviate oxidative stress, inflammation, and endothelial dysfunction in diabetes. Although a beneficial impact was noted in these markers, the endothelial function evidence still requires validation through further clinical trials with a powered sample size.

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Section: Discussionmentioning

confidence: 99%

The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical and Clinical Studies

et al. 2023

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“…Recent research on nanoformulated gallic acid in in vitro models shows great lipid lowering activities [111]. Ellagic acid and 3-hydroxy-3-methylglutaryl-CoA nanoemulsion attenuates fat in in vivo models investigated by Harakeh et al [112], and Dayar and Pechanova [113]. Because of its multimode cardio protective properties, E. officinalis has recently attracted new attention.…”

Section: Health Care Application For Emblicanin-a and Emblicanin-b Na...mentioning

confidence: 99%

Attenuation of Hyperlipidemia by Medicinal Formulations of Emblica officinalis Synergized with Nanotechnological Approaches

et al. 2023

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The ayurvedic herb Emblica officinalis (E. officinalis) is a gift to mankind to acquire a healthy lifestyle. It has great therapeutic and nutritional importance. Emblica officinalis, also known as Indian gooseberry or Amla, is a member of the Euphorbiaceae family. Amla is beneficial for treating illnesses in all its forms. The most crucial component is a fruit, which is also the most common. It is used frequently in Indian medicine as a restorative, diuretic, liver tonic, refrigerant, stomachic, laxative, antipyretic, hair tonic, ulcer preventive, and for the common cold and fever. Hyperlipidemia is also known as high cholesterol or an increase in one or more lipid-containing blood proteins. Various phytocompounds, including polyphenols, vitamins, amino acids, fixed oils, and flavonoids, are present in the various parts of E. officinalis. E. officinalis has been linked to a variety of pharmacological effects in earlier studies, including hepatoprotective, immunomodulatory, antimicrobial, radioprotective, and hyperlipidemic effects. The amla-derived active ingredients and food products nevertheless encounter challenges such as instability and interactions with other food matrices. Considering the issue from this perspective, food component nanoencapsulation is a young and cutting-edge field for controlled and targeted delivery with a range of preventative activities. The nanoformulation of E. officinalis facilitates the release of active components or food ingredients, increased bioaccessibility, enhanced therapeutic activities, and digestion in the human body. Accordingly, the current review provides a summary of the phytoconstituents of E. officinalis, pharmacological actions detailing the plant E. officinalis’s traditional uses, and especially hyperlipidemic activity. Correspondingly, the article describes the uses of nanotechnology in amla therapeutics and functional ingredients.

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“…Ellagic acid plus metformin may prevent type II diabetes-related nephropathy by regulating blood sugar levels, lowering oxidative stress and inflammation, and combating free radicals. This will eventually result in a reduction in the apoptosis of kidney tissue (Harakeh et al, 2023). Ellagic acid protected against oxidative stress, apoptosis, inflammation, and kidney injury.…”

Section: Ellagic Acidmentioning

confidence: 99%

Diabetic nephropathy: An outline on molecular mechanism and protective pathways of phytoconstituents

Hashim,

Badruddeen,

Akhtar

et al. 2023

J. Phytonanotech. Pharmaceut. Sci.

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Diabetic nephropathy is a debilitating complication of diabetes mellitus characterized by progressive kidney damage. This review provides a comprehensive overview of the molecular pathways underlying its pathogenesis and explores the protective mechanisms offered by various phytobioactives. The pathogenetic mechanisms of diabetic nephropathy are multifaceted, encompassing the activation of key pathways such as the rennin angiotensin-aldosterone system (RAAS), the polyol pathway, protein kinase C (PKC) pathway, hexosamine pathway, and the formation of advanced glycation end products (AGEs). Understanding these pathways is crucial for developing effective therapeutic strategies to combat diabetic nephropathy. In parallel, this review sheds light on the role of phytobioactives, including alkaloids, flavonoids, tannins, and stilbenes, in mitigating the progression of diabetic nephropathy. These natural compounds exhibit a spectrum of protective properties, including antioxidative and anti-inflammatory effects. Their ability to modulate the molecular pathways implicated in diabetic nephropathy offers promising avenues for novel therapeutic interventions. This review of the pathogenetic mechanisms and the protective potential of phytobioactives underscore the importance of considering natural compounds as adjunctive therapies in managing diabetic nephropathy, potentially improving patient outcomes and quality of life.

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Ellagic acid nanoparticles attenuate oxidative stress and testicular damage in high fat Diet/Streptozotocin-Induced diabetic rats

Cited by 10 publications

References 34 publications

The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical and Clinical Studies

The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical and Clinical Studies

Attenuation of Hyperlipidemia by Medicinal Formulations of Emblica officinalis Synergized with Nanotechnological Approaches

Diabetic nephropathy: An outline on molecular mechanism and protective pathways of phytoconstituents

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