Ellagic Acid Inhibits Migration and Invasion by Prostate Cancer Cell Lines

Pitchakarn, Pornsiri; Chewonarin, Teera; Ogawa, Kumiko; Suzuki, Shugo; Asamoto, Makoto; Takahashi, Satoru; Shirai, Tomoyuki; Limtrakul, Pornngarm

doi:10.7314/apjcp.2013.14.5.2859

Cited by 63 publications

(43 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In another study, non-cytotoxic dose of ellagic acid (25 and 50 μM) to androgen independent prostate cancer cells markedly suppressed the cell invasion and motility. The effect might be the result of down-regulation of MMPs [147]. Besides, at higher dose (10–100 μM), ellagic acid treatment was found to induce growth inhibition and caspase-dependent apoptosis in PC3 prostate cancer cells in a dose responsive manner [148].…”

Section: Experimental Studiesmentioning

confidence: 99%

Natural Polyphenols for Prevention and Treatment of Cancer

et al. 2016

View full text Add to dashboard Cite

There is much epidemiological evidence that a diet rich in fruits and vegetables could lower the risk of certain cancers. The effect has been attributed, in part, to natural polyphenols. Besides, numerous studies have demonstrated that natural polyphenols could be used for the prevention and treatment of cancer. Potential mechanisms included antioxidant, anti-inflammation as well as the modulation of multiple molecular events involved in carcinogenesis. The current review summarized the anticancer efficacy of major polyphenol classes (flavonoids, phenolic acids, lignans and stilbenes) and discussed the potential mechanisms of action, which were based on epidemiological, in vitro, in vivo and clinical studies within the past five years.

show abstract

Section: Experimental Studiesmentioning

confidence: 99%

Natural Polyphenols for Prevention and Treatment of Cancer

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The secretions of MMP-2 and MMP-9 of the treated cells were analyzed by gelatin zymography as previously described (Pitchakarn et al, 2013). HT1080 and MDA-MB-231 cells were treated with various concentrations (0-100 μg/ml) of the red rice fractions for 24 h in DMEM serum-free medium, and the culture supernatant was collected in equal amounts of the cells.…”

Section: Gelatin Zymography Assaymentioning

confidence: 99%

“…The invasive behavior of MDA-MB-231 and HT1080 cells was tested using the modified Boyden chamber assay as previous described (Pitchakarn et al, 2013). Polyvinylpyrrolidone-free polycarbonate filters (Millipore, Co Cork, Ireland) (8 μm pore sized) were coated with Matrigel (12 μg/filter).…”

Section: Cell Invasion Assaymentioning

confidence: 99%

Anti-invasive Activity against Cancer Cells of Phytochemicals in Red Jasmine Rice (Oryza sativa L.)

Pintha

Yodkeeree²,

Pitchakarn³

et al. 2014

Asian Pacific Journal of Cancer Prevention

Self Cite

View full text Add to dashboard Cite

“…[22][23][24][25][26][27][28][29] These data demonstrated that pomegranate phytochemicals provide protection against various cancer-related processes.…”

mentioning

confidence: 80%

Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention

Shirode¹,

Bharali²,

Nallanthighal³

et al. 2015

IJN

View full text Add to dashboard Cite

Pomegranate polyphenols are potent antioxidants and chemopreventive agents but have low bioavailability and a short half-life. For example, punicalagin (PU), the major polyphenol in pomegranates, is not absorbed in its intact form but is hydrolyzed to ellagic acid (EA) moieties and rapidly metabolized into short-lived metabolites of EA. We hypothesized that encapsulation of pomegranate polyphenols into biodegradable sustained release nanoparticles (NPs) may circumvent these limitations. We describe here the development, characterization, and bioactivity assessment of novel formulations of poly(D,L-lactic- co -glycolic acid)–poly(ethylene glycol) (PLGA–PEG) NPs loaded with pomegranate extract (PE) or individual polyphenols such as PU or EA. Monodispersed, spherical 150–200 nm average diameter NPs were prepared by the double emulsion–solvent evaporation method. Uptake of Alexa Fluor-488-labeled NPs was evaluated in MCF-7 breast cancer cells over a 24-hour time course. Confocal fluorescent microscopy revealed that PLGA–PEG NPs were efficiently taken up, and the uptake reached the maximum at 24 hours. In addition, we examined the antiproliferative effects of PE-, PU-, and/or EA-loaded NPs in MCF-7 and Hs578T breast cancer cells. We found that PE, PU, and EA nanoprototypes had a 2- to 12-fold enhanced effect on cell growth inhibition compared to their free counterparts, while void NPs did not affect cell growth. PU-NPs were the most potent nanoprototype of pomegranates. Thus, PU may be the polyphenol of choice for further chemoprevention studies with pomegranate nanoprototypes. These data demonstrate that nanotechnology-enabled delivery of pomegranate polyphenols enhances their anticancer effects in breast cancer cells. Thus, pomegranate polyphenols are promising agents for nanochemoprevention of breast cancer.

show abstract

Ellagic Acid Inhibits Migration and Invasion by Prostate Cancer Cell Lines

Cited by 63 publications

References 32 publications

Natural Polyphenols for Prevention and Treatment of Cancer

Natural Polyphenols for Prevention and Treatment of Cancer

Anti-invasive Activity against Cancer Cells of Phytochemicals in Red Jasmine Rice (Oryza sativa L.)

Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention

Contact Info

Product

Resources

About