Ellagic acid, extracted from <i>Sanguisorba officinalis</i>, induces G1 arrest by modulating PTEN activity in B16F10 melanoma cells

Tan, Yulin; Shudo, Toshiyuki; Yoshida, Tomoki; Sugiyama, Yuma; Jia, Ying; Tsukano, Chihiro; Takemoto, Yoshiji; Kakizuka, Akira

doi:10.1111/gtc.12719

Cited by 18 publications

(14 citation statements)

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“…It is reported that the water extract of S. officinalis, when used at a relatively low dose (IC 50 < 200 μg/ml) and in combination with 5-fluorouracil, could increase the cytotoxic effect on two colorectal cancer cell lines HCT-116 and RKO by promoting the reactive oxygen species-mediated mitochondrial caspasedependent apoptotic pathway (Liu et al, 2016). A similar effect was observed when ellagic acid isolated from the alcohol extracts of S. officinalis was used in combination with cisplatin treatment (Tan et al, 2019), as reported by numerous scientific studies (García-Niño and Zazueta, 2015;Ceci et al, 2018).…”

Section: Antitumor Effectssupporting

confidence: 74%

“…Methanol extracts of S. officinalis (40, 80, or 120 μg/ml) have demonstrated significant cytotoxic activity against human prostate cancer cells via an intrinsic apoptotic pathway ( Choi et al, 2012a ), in addition to inhibiting the proliferation of human breast cancer cell lines MCF-7 and MDA-MB-231 by inducing S-phase arrest and triggering the mitochondrial pathway of apoptosis ( Wang et al, 2012 ), and causing the blockage of the G1 phase in B16F10 melanoma cells ( Tan et al, 2019 ).…”

Section: Pharmacological Effects Exhibited By Genus Sanguisorbamentioning

confidence: 99%

“…The Plant List ( The Plant List, 2021 ), International Plant Name Index ( International Plant Name Index, 2021 ) and Kew Botanical Garden ( Kew Botanical Garden, 2021a ; Kew Botanical Garden, 2021b ) were used for obtaining the scientific names and information on the subspecies and cultivars. Studies have demonstrated that the crude extracts from plants belonging to genus Sanguisorba or the purified monomers isolated from the plants of this genus exhibit various pharmacological activities, including anti-inflammatory ( Su et al, 2018a ; Guo et al, 2019 ; Yasueda et al, 2020 ), anti-cancer ( Liu et al, 2016 ; Nam et al, 2017 ; Tan et al, 2019 ; Bai et al, 2020a ; Liao et al, 2020 ), anti-lipid peroxidation ( Zhang et al, 2012a ; Romojaro et al, 2013a ; Kim et al, 2018a ; Lenzi et al, 2019 ), anti-bacteria ( Su et al, 2019 ; Zhu et al, 2020a ), anti-diabetes ( Kuang et al, 2011 ; Son et al, 2015 ), hepatoprotective ( Stojiljković et al, 2019 ; Meng et al, 2020 ), and anti-obesity ( Jung et al, 2016 ; Im et al, 2017 ; Ji et al, 2018 ) properties, both in vitro and in vivo ( Figure1 ).…”

Section: Introductionmentioning

confidence: 99%

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A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

Zhou

Chen

et al. 2021

Front. Pharmacol.

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Genus Sanguisorba (family: Rosaceae) comprises nearly 148 species, distributed widely across the temperate and subtropical regions of the Northern Hemisphere. Sanguisorba officinalis L. (S. officinalis) has been used as a hemostatic and scald treating medicine in China for a long time. Numerous studies have demonstrated that plant extracts or monomers from S. officinalis exhibit several pharmacological effects, such as anti-cancer, anti-virus, anti-inflammation, anti-bacteria, neuroprotective and hepatoprotective effects. The other species of genus Sanguisorba are also being studied by researchers worldwide. Sanguisorba minor Scop. (S. minor), as an edible wild plant, is a common ingredient of the Mediterranean diet, and its young shoots and leaves are often mixed with traditional vegetables and consumed as salad. Reports on genus Sanguisorba available in the current literature were collected from Google Scholar, Web of Science, Springer, and PubMed. The Plant List (http://www.theplantlist.org./tpl1.1/search?q=Sanguisorba), International Plant Name Index (https://www.ipni.org/?q=Sanguisorba) and Kew Botanical Garden (http://powo.science.kew.org/) were used for obtaining the scientific names and information on the subspecies and cultivars. In recent years, several in vivo and in vitro experiments have been conducted to reveal the active components and effective monomers of S. officinalis and S. minor. To date, more than 270 compounds have been isolated and identified so far from the species belonging to genus Sanguisorba. Numerous reports on the chemical constituents, pharmacologic effects, and toxicity of genus Sanguisorba are available in the literature. This review provides a comprehensive understanding of the current traditional applications of plants, which are supported by a large number of scientific experiments. Owing to these promising properties, this species is used in the treatment of various diseases, including influenza virus infection, inflammation, Alzheimer’s disease, type 2 diabetes and leukopenia caused by bone marrow suppression. Moreover, the rich contents and biological effects of S. officinalis and S. minor facilitate these applications in dietary supplements and cosmetics. Therefore, the purpose of this review is to summarize the recent advances in the traditional uses, chemical constituents, pharmacological effects and clinical applications of genus Sanguisorba. The present comprehensive review may provide new insights for the future research on genus Sanguisorba.

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Section: Antitumor Effectssupporting

confidence: 74%

Section: Pharmacological Effects Exhibited By Genus Sanguisorbamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

Zhou

Chen

et al. 2021

Front. Pharmacol.

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“…The present study used HG to treat rat MCs to establish a DN model in vitro . EA is a type of polyphenol compound, widely used in Chinese herbal medicines, such as sanguisorba officinalis and pomegranate peel ( 27 , 28 ). Numerous studies have demonstrated that EA possesses multiple biological activities in vitro ( 14 , 29 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

Ellagic acid inhibits high glucose‑induced injury in rat mesangial cells via the PI3K/Akt/FOXO3a signaling pathway

et al. 2021

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The pathological damage of mesangial cells serves an important role in the occurrence and development of diabetic nephropathy. Ellagic acid has been reported to possess antioxidant, antitumor, antiviral and anti-inflammatory properties in several diseases, but the roles of ellagic acid in diabetic nephropathy are unclear. The main aim of the present study was to investigate the effect of ellagic acid on high glucose-induced mesangial cell damage. The results revealed that high glucose could induce the hyperproliferation of mesangial cells, decrease the activity of superoxide dismutase, increase the malondialdehyde content, the level of reactive oxygen species, the secretion of inflammatory factors (TNF-α, IL-1β and IL-6) and the synthesis of extracellular matrix (Fibronectin, MMP-9 and TIMP-1) and activate the PI3K/Akt/FOXO3a signaling pathway. Ellagic acid could attenuate the injury of mesangial cells induced by high glucose in a concentration-dependent manner and its effect was consistent with that of a PI3K inhibitor (LY294002). Moreover, a PI3K agonist (740Y-P) reversed the protective effect of ellagic acid on mesangial cells induced by high glucose. In conclusion, ellagic acid protected mesangial cells from high glucose-induced injury in a concentration-dependent manner. The mechanism may be associated with ellagic acid inhibiting the activation of the PI3K/Akt signaling pathway and reducing the expression levels of downstream transcription factor FOXO3a.

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“…Filipendula [16], Alchemilla [17], Potentilla [18,19], Sanguisorba [20,21], Rubus [22,23], Fragaria [24], Rosa [25].…”

Section: Ellagic Acid-4acetylarabinoside 101129363mentioning

confidence: 99%

Ellagic Acid Derivatives: Possible Drugs Against Metapneumovirus?

Artamonova¹,

Abdullatypov²

2022

Preprint

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Human metapneumovirus is one of major causes of common cold among children, especially infants. Its key enzyme is RNA-dependent RNA-polymerase, which performs both replication and transcription, including capping and cap methylation. The goal of the work is to find possible inhibitors of RNA-dependent RNA-polymerase across the active compounds of Rosaceae plants. The candidates were selected by molecular docking to cap-transferring domain of RNA-polymerase (PDB ID: 4UCZ) in Autodock VINA. Among all the substances tested by docking, ellagic acid derivatives showed the most promising results (affinity values below -10 kcal/mol). Hence, they could be treated as possible candidate drugs against metapneumoviral infection after experimental examination. The main advantage of using these substances should be their low toxicity, which is quite uncommon for selective RNA polymerase inhibitors used in clinical practice. Occurrence of ellagic acid derivatives among the plants from Rosaceae family like raspberry could explain their effect during common cold.

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Ellagic acid, extracted from Sanguisorba officinalis, induces G1 arrest by modulating PTEN activity in B16F10 melanoma cells

Cited by 18 publications

References 58 publications

A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

Ellagic acid inhibits high glucose‑induced injury in rat mesangial cells via the PI3K/Akt/FOXO3a signaling pathway

Ellagic Acid Derivatives: Possible Drugs Against Metapneumovirus?

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