Ellagic acid and hydroxyapatite promote angiogenesis marker in bone defect

Nirwana, Intan; Munadziroh, Elly; Yuliati, Anita; Fadhila, Azalia Izzah; Nurliana,; Wardhana, Agung Satria; Shariff, Khairul Anuar; Surboyo, Meircurius Dwi Condro

doi:10.1016/j.jobcr.2021.11.008

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…The CBPO composite coating was found to significantly promote angiogenesis and accelerate bone repair and that can be attributed to three reasons: the release of VEGF from CS/BSA‐NPs can regulate vascularization and promote the formation of new blood vessels during bone healing 48 ; the release of BMP‐2 from PLL/OALG‐NPs can enhance differentiation of stem cells and induce new bone formation 49 ; and the tunable release of VEGF and BMP‐2 from the composite coating, fulfilling the biological functions of VEGF and BMP‐2 and synergistically accelerating bone defect healing. The rapid release of VEGF can promote the formation of new blood vessels in the vascularization stage, providing adequate blood and nutrient supply for bone regeneration 50,51 . The sustained release of BMP‐2 can promote bone regeneration over a long period 52–54 …”

Section: Discussionmentioning

confidence: 99%

“…The rapid release of VEGF can promote the formation of new blood vessels in the vascularization stage, providing adequate blood and nutrient supply for bone regeneration. 50,51 The sustained release of BMP-2 can promote bone regeneration over a long period. [52][53][54] The bone healing potentials of single growth factor-loaded TCP scaffolds were compared and the CBPO group showed better performance than the VEGF or BMP-2 groups.…”

Section: Discussionmentioning

confidence: 99%

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Nanoparticles based composite coatings with tunable vascular endothelial growth factor and bone morphogenetic protein‐2 release for bone regeneration

Chen

Wei

2022

J Biomedical Materials Res

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Bone healing is a complex cascade involving precisely coordinated spatiotemporal presentation of multiple growth factors (GFs), including osteogenic and angiogenic GFs, and each stage of bone healing requires varying types and content of GFs. In this study, we fabricated a composite nanocoating with tunable vascular endothelial growth factor (VEGF) and bone morphogenetic protein‐2 (BMP‐2) that was coated on the surface of a polydopamine (PDA)‐decorated tertiary calcium phosphate (TCP) scaffold using VEGF‐loaded chitosan/bovine serum albumin nanoparticles (CS/BSA‐NPs) and BMP‐2‐loaded poly‐L‐lysine/oxidized alginate nanoparticles (PLL/OALG‐NPs). It was found that VEGF could be efficiently released to promote vascularization in early bone repair stages due to the rapid biodegradation of CS/BSA‐NPs, while bone formation can be promoted by a sustained release of BMP‐2 from the slowly degrading PLL/OALG‐NPs. The composite coating and TCP scaffold can be conjugated due to the excellent adhesive property of PDA. The composite coating can achieve the rapid release of VEGF and sustained release of BMP‐2, which can activate GFs for accelerating bone healing.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nanoparticles based composite coatings with tunable vascular endothelial growth factor and bone morphogenetic protein‐2 release for bone regeneration

Chen

Wei

2022

J Biomedical Materials Res

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“…↑ in the expression of FGF-2, VEGF and ALP ↑ IL-10, BMP-4 and OPN ↓ TNF-α and increasing the expression of [116,117] Melibiose, melezitose, ganolactone B, methylophiopogonanone A, ↑ expression of ALP, osteocalcin, osterin, osteoprotegerin, and autophagy marker proteins activation of BMP2/Smad/Runx2 and Wnt/β-catenin signaling Juglans regia [118] tubuloside…”

Section: Ellagic Acid and Hydroxyapatitementioning

confidence: 99%

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Hanga-Farcaș¹,

Miere²,

Filip³

et al. 2023

Preprint

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Bone metabolism is a complex process which is influenced by the activity of bone cells (e.g., osteocytes, osteoblasts, osteoclasts), the effect of some specific biomarkers (e.g., parathyroid hormone, vitamin D, alkaline phosphatase, osteocalcin, osteopontin, osteoportegerin, osterix, RANKL, Runx2) and the characteristic signaling pathways (e.g., RANKL/RANK, Wnt/β, Notch, BMP, SMAD). Some phytochemical compounds such as flavonoids, tannins, polyphenols, anthocyanins, terpenoids, polysaccharides, alkaloids and others presented a beneficial and stimulating effect in the bone regeneration process due to pro-estrogenic activity, antioxidant and anti-inflammatory effects and modulation of bone signaling pathways. Lately, nanomedicine has emerged as an innovative concept for new treatments in bone related pathologies envisaged by incorporation of medicinal substances in nanometric systems for oral or local administration, as well as in nanostructured scaffolds with huge potential in bone tissue engineering.

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“…Angiogenesis or vasculogenesis is a therapeutic process that leads to the sprouting of new blood capillaries from the pre-existing parent blood vessel. 14,15 This phenomenon is considered to be one of the crucial approaches in implant dentistry and other pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, we synthesized calcium phosphate through the hydrothermal method at three different pH values ranging from slight acidic (M‐CP), neutral (MH‐CP), and alkaline (H‐CP) then their characteristic were examined by structural, morphological, functional analysis and also unique pro‐angiogenic properties. Angiogenesis or vasculogenesis is a therapeutic process that leads to the sprouting of new blood capillaries from the pre‐existing parent blood vessel 14,15 . This phenomenon is considered to be one of the crucial approaches in implant dentistry and other pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

Influence of pH in the synthesis of calcium phosphate based nanostructures with enhanced bioactivity and pro‐angiogenic properties

2022

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In synthetic fabrication, the process parameters decide the growth nucleation, phase translation, and the evolution of morphological facets of nanostructured materials. This work demonstrates the formation of different crystallographic phases of calcium phosphate by the influence of pH from acidic to alkaline conditions and also investigated their bone regeneration, protein adsorption, and pro‐angiogenic properties. Present results illustrate that the alteration of pH is the crucial factor for the synthesis of calcium phosphate (CP) phases. The structural analysis reveals the monetite (CaHPO4) phase with a triclinic crystal system for pH 5, dual‐phase of monetite combined with hydroxyapatite at the neutral pH 7, and pure phase of hydroxyapatite (Ca10[PO4]6OH2) with hexagonal structure at pH 10. Microscopic analysis portrays the cubic and rod‐like morphologies by changing the pH values. FTIR and RAMAN spectroscopic analyses confirm the stretching, bending, and vibrational modes of dominant phosphate groups of different CP phases. Further, the biocompatibility of the prepared CP phases was examined by hemolysis assay, which showed less than 2% of lysis and enhanced cell viability. Moreover, the bioactivity study revealed rapid mineralization and a higher protein adsorption rate for the monetite CP phase (M‐CP). Subsequently, the chick embryo angiogenesis assay elucidated 33% higher neovascularization for M‐CP compared with the other two CP phases. The fabricated M‐CP nanostructure constitutes a promising candidate for biomedical applications.

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Ellagic acid and hydroxyapatite promote angiogenesis marker in bone defect

Cited by 7 publications

References 27 publications

Nanoparticles based composite coatings with tunable vascular endothelial growth factor and bone morphogenetic protein‐2 release for bone regeneration

Nanoparticles based composite coatings with tunable vascular endothelial growth factor and bone morphogenetic protein‐2 release for bone regeneration

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Influence of pH in the synthesis of calcium phosphate based nanostructures with enhanced bioactivity and pro‐angiogenic properties

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