Ellagic acid: A promising protective remedy against testicular toxicity induced by arsenic

Mehrzadi, Saeed; Bahrami, Nosrat; Mehrabani, Mehrnaz; Motevalian, Manijeh; Mansouri, Esrafil; Goudarzi, Mehdi

doi:10.1016/j.biopha.2018.04.194

Cited by 42 publications

(20 citation statements)

References 61 publications

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“…The blood glucose levels were determined using an Elegance glucometer (CT-X10, Convergent Technologies, Germany). In order to evaluate biochemical factors, serum was separated by blood centrifugation for 10 min at 2000 g , 4 °C and stored at -20 °C until analysis ( 16 ). To evaluate the serum insulin levels, a commercial ELISA kit (Monobind, California, USA) was used according to the manufacturer’s instructions.…”

Section: Methodsmentioning

confidence: 99%

Hypoglycemic, hepatoprotective, and hypolipidemic effects of hydroalcoholic extract of Eryngium billardieri root on nicotinamide/streptozotocin-induced type II diabetic rats

Khani

Abdollahi

Asadi

et al. 2021

Research in Pharmaceutical Sciences

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Background and purpose: Erynginum billardieri has been used to control diabetes in traditional medicine. This research was performed to study the antidiabetic, hepatoprotective, and hypolipidemic effects of E. billardieri root extract (EBRE) on streptozotocin/nicotinamide-induced type 2 diabetic male rats. Experimental approach: Type two diabetic animals were treated by three different doses of EBRE (100, 200, and 400 mg/kg), orally administered for 4 weeks. Ultimately, after anesthesia, the glucose, insulin, lipid profiles, hepatic enzyme levels in the blood and liver, and pancreas tissues of the animals were analyzed. Findings/Results: Induction of diabetes caused a diminution in insulin level, high-density lipoprotein (HDL), and significantly enhanced the level of other lipid profiles, glucose, and liver enzymes ( P < 0.05). Administration of the EBRE to diabetic-male rats significantly reduced glucose level, lipid profiles, and liver enzymes, and increased the level of HDL to near normal. Conclusion and implications: The results of the present study showed that E. billardieri had a positive effect on diminishing the lipid profiles, liver enzymes, and controlling diabetes. The most effective dose was found to be 100 mg/kg.

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Section: Methodsmentioning

confidence: 99%

Hypoglycemic, hepatoprotective, and hypolipidemic effects of hydroalcoholic extract of Eryngium billardieri root on nicotinamide/streptozotocin-induced type II diabetic rats

Khani

Abdollahi

Asadi

et al. 2021

Research in Pharmaceutical Sciences

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show abstract

“…Serum antioxidant enzyme superoxide dismutase (SOD) (ZB-SOD-96A), glutathione peroxidase (GPX) (ZB-GPX-96A) (18), and catalase (CAT) (ZB-CAT-96A) activities were measured using ELISA assays kits (ZellBio GmbH, Germany), according to the provider's instructions.…”

Section: Antioxidant Assessmentmentioning

confidence: 99%

The effect of hydroalcoholic extract of Nigella Sativa seed on dehydroepiandrosterone-induced polycystic ovarian syndrome in rats: An experimental study

Khani¹,

Abdollahi²,

Khalaj³

et al. 2021

IJRM

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Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women. Objective: The aim of this study was to investigate the therapeutic effect of hydroalcoholic extract of Nigella sativa (N. sativa) seed as a plant, the consumption of which has been recommended in Islam, on dehydroepiandrosterone (DHEA)-induced PCOS rats. Materials and Methods: This experimental study was carried out on 36 Wistar female rats (3 wk, 60 ± 10 gr). Then rats were divided into 6 groups (n = 6/each): control; PCOSinduced (DHEA 60 mg/kg/sc); PCOS + Metformine (30 mg/kg); and three experimental groups receiving DHEA + hydroalcoholic extract of N. sativa seeds in doses of 50, 100 and 200 mg/kg, respectively. Blood samples were taken for the evaluation of sexual hormones, oxidative stress, glucose, and insulin after 30 days of treatment. Ovarian tissue was used for histopathological study. Results: The serum levels of luteinizing hormone, testosterone, glucose, insulin resistance, malondialdehyde, and insulin (p ≤ 0.001) and estrogen increased while the levels of progesterone (p = 0.01) and antioxidant enzymes in the PCOS group decreased (p ≤ 0.001). Conclusion: The administration of the N. sativa extract to the PCOS rats resulted in remarkable changes in the serumic factors relative to the PCOS group. In addition, the extract improved the structure of the ovarian tissue in the PCOS rat. The histopathological results which are in accordance with biochemical findings imply that N. sativa seed could be useful in the treatment of PCOS, the higher doses of the extract being more effective. Key words: Nigella sativa seed, Oxidative stress, Insulin resistance, Polycystic ovary syndrome, Rat.

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“…Ellagic acid directly eliminates reactive oxygen and nitrogen species, such as hydroxyl radicals, hydrogen peroxide, peroxyl, and peroxynitrite radicals. In addition, it prevents oxidative stress by activating cellular antioxidant enzyme systems and is capable of forming a complex with iron ions, which contributes to the reduction of free radical formation (Mehrzadi et al, 2018).…”

Section: Boletín Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas/ 238mentioning

confidence: 99%

Inhibition of α-glucosidase, pancreatic lipase, and antioxidant property of Myrcia hatschbachiiD. Legrand containing gallic and ellagic acids

Gatto¹,

Oliveira²,

Rech³

et al. 2021

BLACPMA

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Several species of the Myrcia genus have been used in folk medicine to treat diabetes. Therefore, the aim of this work was to investigate the inhibitory activity of α-glucosidase and pancreatic lipase in the crude extract (EBF) and in the ethyl acetate fraction (FFA) of Myrcia hatschbachii, as well as to identify isolated phenolic compounds and to evaluate the antioxidant property and preliminary in vitro toxicity against Artemia salina. EBF (IC50: 3.21 μg/mL) and FFA (IC50: 1.14 μg/mL) showed inhibitory activity superior to acarbose (IC50: 193.65 μg/mL). In addition, they showed inhibitory effects of pancreatic lipase (IC50: 556.58 μg/mL for EBF and 532.68 μg/mL for FFA), antioxidant potential, absence of preliminary toxicity and presence of gallic andellagic acids in FFA. The relevant results in the inhibition of α-glucosidase and pancreatic lipase motivate new studies for the development of herbal medicines that assist in the treatment of diabetic patients.

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Ellagic acid: A promising protective remedy against testicular toxicity induced by arsenic

Cited by 42 publications

References 61 publications

Hypoglycemic, hepatoprotective, and hypolipidemic effects of hydroalcoholic extract of Eryngium billardieri root on nicotinamide/streptozotocin-induced type II diabetic rats

Hypoglycemic, hepatoprotective, and hypolipidemic effects of hydroalcoholic extract of Eryngium billardieri root on nicotinamide/streptozotocin-induced type II diabetic rats

The effect of hydroalcoholic extract of Nigella Sativa seed on dehydroepiandrosterone-induced polycystic ovarian syndrome in rats: An experimental study

Inhibition of α-glucosidase, pancreatic lipase, and antioxidant property of Myrcia hatschbachiiD. Legrand containing gallic and ellagic acids

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