ELK1-induced upregulation of long non-coding RNA MIR100HG predicts poor prognosis and promotes the progression of osteosarcoma by epigenetically silencing LATS1 and LATS2

Su, Xiaochuan; Teng, Junyan; Jin, Guoguo; Li, Jitian; Zhao, Zhenjiang; Cao, Xiangyang; Guo, Yuna; Guo, Malong; Li, Xiaoling; Wu, Jun; Wang, Chuanzhen; Guo, Zhiping; Guo, Qing

doi:10.1016/j.biopha.2018.10.029

Cited by 52 publications

(56 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study performed by Yu et al 40 suggested lncRNA BCYRN1 functioned as an oncogene by sponging miR‐125a‐5p to activate TAZ, and then results in cell proliferation, invasion and migration in glioma. In addition, Su et al 42 demonstrated that mir‐100‐let‐7a‐2‐mir‐125b‐1 cluster host gene (MIR100HG), a well‐documented tumour facilitator in breast cancer 43 and acute megakaryoblastic leukaemia, 44 was also highly expressed in osteosarcoma. Functional assay and rescue experiments further confirmed that MIR100HG regulated cell proliferation, apoptosis and cell cycle mediated by epigenetically silencing LATS1/2 and inactivating Hippo pathway 42 .…”

Section: Regulatory Network Of Lncrnas and Hippo Signalling Pathway Imentioning

confidence: 99%

The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression

Yang

Lü

et al. 2020

Cell Proliferation

View full text Add to dashboard Cite

LncRNAs play a pivotal role in the regulation of epigenetic modification, cell cycle, differentiation, proliferation, migration and other physiological activities. In particular, considerable studies have shown that the aberrant expression and dysregulation of lncRNAs are widely implicated in cancer initiation and progression by acting as tumour promoters or suppressors. Hippo signalling pathway has attracted researchers’ attention as one of the critical cancer‐related pathways in recent years. Increasing evidences have demonstrated that lncRNAs could interact with Hippo cascade and thereby contribute to acquisition of multiple malignant hallmarks, including proliferation, metastasis, relapse and resistance to anti‐cancer treatment. Specifically, Hippo signalling pathway is reported to modulate or be regulated by widespread lncRNAs. Intriguingly, certain lncRNAs could form a reciprocal feedback loop with Hippo signalling. More speculatively, lncRNAs related to Hippo pathway have been poised to become important putative biomarkers and therapeutic targets in human cancers. Herein, this review focuses on the crosstalk between lncRNAs and Hippo pathway in carcinogenesis, summarizes the comprehensive role of Hippo‐related lncRNAs in tumour progression and depicts their clinical diagnostic, prognostic or therapeutic potentials in tumours.

show abstract

Section: Regulatory Network Of Lncrnas and Hippo Signalling Pathway Imentioning

confidence: 99%

The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression

Yang

Lü

et al. 2020

Cell Proliferation

View full text Add to dashboard Cite

show abstract

“…It has been revealed that lncRNAs are involved in the regulation of various cancers, such as lung cancer [21], osteosarcoma [22], colorectal cancer [23] and breast cancer [24]. LncRNA AFAP1-AS1 has been revealed to play a vital role in promoting cancers progression [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA AFAP1-AS1 accelerates the progression of melanoma by targeting miR-653-5p/RAI14 axis

Liu

Pei

et al. 2020

BMC Cancer

View full text Add to dashboard Cite

Background: Melanoma is the most aggressive skin cancer that derived from pigment cells, accounting for the majority of the skin-cancer-related deaths. Despite great development and evolution have been made in surgery, radiotherapy and adjuvant chemotherapy, the prognosis of melanoma patients exhibited no significant improvement. Long noncoding RNAs (lncRNAs) are frequently dysregulated and involved in the development of cancers. LncRNA AFAP1-AS1 has been explored in various cancers, whereas its role and regulatory mechanism in melanoma are not well understood. Methods: The expression of AFAP1-AS1 was detected by qRT-PCR. CCK-8, colony formation, transwell and western blot assays were performed to investigate the biological role of AFAP1-AS1 in melanoma. Male BALB/c nude mice were applied for in vivo experiments. The interaction among AFAP1-AS1, miR-653-5p and RAI14 was investigated by RNA pull down, RIP and luciferase reporter assays. Results: AFAP1-AS1 was highly expressed in melanoma cell lines. Suppression of AFAP1-AS1 impaired cell proliferation, migration, invasion and EMT in melanoma. Moreover, AFAP1-AS1 was a ceRNA of RAI14 by competitively binding with miR-653-5p. Besides, miR-653-5p overexpression or RAI14 inhibition could repress tumor growth. Eventually, rescue assays indicated that the function of AFAP1-AS1 in the cellular process of melanoma was dependent on miR-653-5p and RAI14. Conclusions: AFAP1-AS1 exerts its oncogenic function in melanoma by targeting miR-653-5p/RAI14 axis.

show abstract

“…Among them, 17 associations including two pairs of TF regulation and 17 pairs of RBP interaction were found to be co‐expressed. One of 2 TFs, ELK1 , is an important regulator and known to activate many lncRNAs including TRPM2‐AS , MIR100HG , and HOXA10‐AS in cancer until now, indicating ELK1 may induce expression of LINC01234 to promote tumor progression in GC too.…”

Section: Discussionmentioning

confidence: 99%

Function and regulation annotation of up‐regulated long non‐coding RNA LINC01234 in gastric cancer

Zhu

Luo

Korakkandan

et al. 2020

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background Accumulated evidences indicate that long non‐coding RNAs (lncRNAs) participate in many biological mechanisms. Moreover, it acts as an essential regulator in various human diseases such as gastric cancer (GC). Nevertheless, the comprehensive regulatory roles and clinical significance of most lncRNAs in GC are not fully understood. Methods In this research, our aim was to investigate the underlying mechanism of lncRNA LINC01234 in GC. Firstly, the usage of qRT‐PCR helped to establish expression pattern of LINC01234 in GC tissues. Following this, appropriate statistical tests were applied to analyze the relation between expression level and clinicopathological factors. Ultimately, potential functions and regulatory network of LINC01234 were concluded via GSEA and a series of bioinformatics tools or databases, respectively. Results Consequently, at the end of research we found LINC01234 is up‐regulated in GC tissues in comparison with adjacent normal tissues. Furthermore, its expression level is correlated with differentiation of patients with GC. It is also important to highlight bioinformatics analysis revealed that LINC01234 is involved in cancer‐associated pathways such as cell cycle and mismatch repair. Also, regulatory network of LINC01234 presented a probability in the involvement of tumorigenesis through regulating cancer‐associated genes. Conclusion Overall, our results suggested that LINC01234 may play a crucial role in GC.

show abstract

ELK1-induced upregulation of long non-coding RNA MIR100HG predicts poor prognosis and promotes the progression of osteosarcoma by epigenetically silencing LATS1 and LATS2

Cited by 52 publications

References 42 publications

The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression

The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression

Long non-coding RNA AFAP1-AS1 accelerates the progression of melanoma by targeting miR-653-5p/RAI14 axis

Function and regulation annotation of up‐regulated long non‐coding RNA LINC01234 in gastric cancer

Contact Info

Product

Resources

About