Elisas for Rotavirus Diagnosis, Typing, and Analysis of Antibody Response

Safety and immunogenicity of a parenterally administered rotavirus VP8 subunit vaccine in healthy adults

“…Binding antibody responses were almost universally induced, and IgA responses to the P2-VP8 were demonstrated in all vaccinees, at all dose levels. It is important to note that previous assessment of IgA responses as a possible correlate of protection has been based on IgA assays using antigens from whole virus lysates, presumed to be predominantly VP6 [29], and no inferences about whether VP8-specific responses are meaningful in terms of protection can be made at this stage. The ALS IgA responses demonstrated in the majority of participants receiving the highest vaccine dose are also encouraging.…”