Elimination of tick populations from ecosystems

Novikov, V. N.; Vshivkova, O. A.; Kruglik, O. V.; Morgulis, I. I.; Khlebopros, R. G.

doi:10.1134/s0012496608030204

Cited by 1 publication

(1 citation statement)

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“…This decrease, however, only lasted in the year the measurements were applied, indicating that tick abundance is very resilient and heavily regulated by the tick population [ 243 ]. A model looking at the population of murine reservoirs in relation to ixodid tick abundance in Siberia showed that there is a threshold level below which murine populations are no longer able to support tick populations and could aid in the reduction of ticks [ 244 ]. In addition to having reservoir populations too low to support tick populations, a model taking into account transmission of tick-borne pathogens showed that when reservoir populations become too high, disease transmission can be hindered due to a dilutive effect [ 245 ].…”

Section: Reservoir Targeted Vaccinesmentioning

confidence: 99%

Resistance to Ticks and the Path to Anti-Tick and Transmission Blocking Vaccines

Oosterwijk

Wikel

2021

Vaccines

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The medical and veterinary public health importance of ticks and tick-borne pathogens is increasing due to the expansion of the geographic ranges of both ticks and pathogens, increasing tick populations, growing incidence of tick-borne diseases, emerging tick transmitted pathogens, and continued challenges of achieving effective and sustained tick control. The past decades show an increasing interest in the immune-mediated control of tick infestations and pathogen transmission through the use of vaccines. Bovine tick resistance induced by repeated infestations was reported over a century ago. This review addresses the phenomena and immunological underpinning of resistance to tick infestation by livestock and laboratory animals; the scope of tick countermeasures to host immune defenses; and the impact of genomics, functional genomics, and proteomics on dissecting complex tick–host–pathogen interactions. From early studies utilizing tick tissue extracts to salivary gland derived molecules and components of physiologically important pathways in tick gut and other tissues, an increased understanding of these relationships, over time, impacted the evolution of anti-tick vaccine antigen selection. Novel antigens continue to emerge, including increased interest in the tick microbiome. Anti-tick and transmission blocking vaccines targeting pathogen reservoirs have the potential to disrupt enzootic cycles and reduce human, companion, domestic animal, and wildlife exposure to infected ticks.

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Section: Reservoir Targeted Vaccinesmentioning

confidence: 99%