Elimination of the non-spectral matrix interferences in the analysis of bio-liquids by mass spectrometry with inductively coupled plasma

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

“…Matrix effects leading to signal suppression or enhancement are well known in ICP-MS analysis of clinical materials. A detailed study by Seregina et al 74 systematically investigated the impact of HNO 3 , inorganic salts and organic compounds on ICP-MS response as well as considering strategies to reduce non-spectral interferences. A combination of optimised “robust” instrumental parameters (most importantly increased radiofrequency power and decreased Ar carrier gas velocity) achieved sufficient reduction of matrix effects to allow use of a single IS for all elements regardless of IP, albeit with a reduction in sensitivity compared with standard instrumental parameters.…”