Elimination of representative fluoroquinolones, penicillins, and cephalosporins by solar photo-Fenton: degradation routes, primary transformations, degradation improvement by citric acid addition, and antimicrobial activity evolution

Serna-Galvis, Efraím A.; Cáceres-Peña, Ana Carolina; Torres-Palma, Ricardo A.

doi:10.1007/s11356-020-10069-8

Cited by 30 publications

(13 citation statements)

References 76 publications

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“…The residual solution's antimicrobial activity assessment is also important since the degradation products could still exhibit toxicity to bacteria, although the original compound is converted by the ozonation process (Serna-Galvis et al 2020). The present study observed lower antimicrobial activity of the GAT degradation products compared to the original compound since the PEQ was always less than 100% (Table S1).…”

Section: Residual Antimicrobial Activitymentioning

confidence: 61%

“…The residual antimicrobial activity assessment is fully important since the bacteria growth in the presence of subminimal inhibitory concentration antibiotic levels is a crucial aspect of the antibiotic resistance crisis (Andersson & Hughes 2014). Due to this, the antimicrobial activity assessment has been widely performed to verify the effectiveness of degradations processes, such as ozonation (Venancio et al 2018;Serna-Galvis et al 2020;Venancio et al 2020). Also, studies with B. subtilis and E. coli reported EC 50 in μg L À1 levels for FQs (Pérez et al 2015;De Oliveira et al 2017), which was the same magnitude those observed in the present one (i.e., 1.1 μg L À1 (2.9 nmol) and 3.6 μg L À1 (9.6 nmol) for B. subtilis and E. coli, respectively).…”

Section: Residual Antimicrobial Activitymentioning

confidence: 99%

“…Other studies have also reported a reduction in the antimicrobial activity after degradation processes. Serna-Galvis et al (2020) observed that a structural transformation during the electrochemical degradation reduced the antimicrobial activity of the FQs to E. coli. Venancio et al (2020) also observed that photocatalyst degradation of FQs decreased the antimicrobial activity to both Gram-positive and Gram-negative bacteria, as observed in the present study.…”

Section: Residual Antimicrobial Activitymentioning

confidence: 99%

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Evaluation of residual antimicrobial activity and acute toxicity during the degradation of gatifloxacin by ozonation

Caianelo

Rodrigues-Silva

Maniero

et al. 2021

Water Science and Technology

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The concerns regarding the occurrence of pharmaceuticals in wastewater treatment plants have been increased in the last decades. Gatifloxacin (GAT), the fourth generation of fluoroquinolones, has been widely used to treat both Gram-positive and Gram-negative bacteria and has a limited metabolization. The present study aimed to evaluate the ozonation as a technique to degrade GAT. A UHPLC-MS/MS method was used to quantify the residual of GAT and to assess its degradation products. The removal efficiency was higher at alkaline condition (pH = 10), reaching up to 99% of GAT after 4 min. It was also observed that the first ozone attack on the GAT molecule was through the carboxylic group. In contrast, at acid conditions (pH = 3), the ozone attack was first to the piperazinyl ring. The antimicrobial activity was evaluated using Escherichia coli and Bacillus subtilis as test organisms, and it was observed that the residual activity reduced most at the alkaline conditions. In contrast, the best condition to remove the residual toxicity evaluated for the marine bacteria V. fischeri was the acidic one. Due to this, the ozonation seemed to be an exciting process to remove GAT at aqueous media.

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Section: Residual Antimicrobial Activitymentioning

confidence: 61%

Section: Residual Antimicrobial Activitymentioning

confidence: 99%

Section: Residual Antimicrobial Activitymentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of residual antimicrobial activity and acute toxicity during the degradation of gatifloxacin by ozonation

Caianelo

Rodrigues-Silva

Maniero

et al. 2021

Water Science and Technology

View full text Add to dashboard Cite

show abstract

“…These results suggest that the production of hydroxyl radicals by the reaction between the iron and the hydrogen peroxide (Eq. 1) is limited due to the iron is not in soluble forms (Pignatello et al 2006;Serna-Galvis et al 2020). Consequently, the elimination of pollutants is low.…”

Section: Treatment Of the Representative Pharmaceuticals By Solar Photo-fentonmentioning

confidence: 99%

Improvement of solar photo-Fenton by extracts of amazonian fruits for the degradation of pharmaceuticals in municipal wastewater

Losada

Santanilla-Calderón

Serna-Galvis

et al. 2021

Environ Sci Pollut Res

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Extracts of copoazu (Theobroma gramdiflorum), canangucha (Maurita Flexuosa), and coffee (coffea arabica) were explored as enhancers of the solar photo-Fenton process to eliminate acetaminophen, sulfamethoxazole, carbamazepine, and diclofenac. The process performance, at pH 6.2 and 5 mg L -1 of iron without the extracts, has a very limited action (~35% of the pollutants degradation at 90 min of treatment) due to the iron precipitation. Interestingly, the extracts addition increased the soluble iron forms but only copoazu extract improved the pollutants degradation (~95% of elimination at 90 min of the process action). The copoazu extract acted as a natural complexing agent, maintaining the soluble iron up to 2 mg L -1 even after 90 min, and consequently enhancing the pollutants degradation. The effect of copoazu extract dose on the process performance was also assessed, finding that an iron: copoazu extract molar ratio equal to 1:0.16 was the most favorable condition. Then, the process improved by copoazu extract was applied to municipal wastewater.Remarkably, the process led to ~90% of total pharmaceuticals degradation at 20 min of treatment. This work evidences the feasibility of amazonian fruits extracts to improve the solar photo-Fenton process to degrade pharmaceuticals in aqueous matrices at near-neutral pH.

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“…1) is limited due to the iron is not in soluble forms (Pignatello et al 2006;Serna-Galvis et al 2020). Consequently, the elimination of pollutants is low.…”

Section: Treatment Of the Representative Pharmaceuticals By Solar Phomentioning

confidence: 99%

Improvement of Solar Photo-Fenton by Extracts of Amazonian Fruits for the Degradation of Pharmaceuticals in Municipal Wastewater

Losada

Santanilla-Calderón

Serna-Galvis

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Extracts of copoazu (Theobroma gramdiflorum), canangucha (Maurita Flexuosa), and coffee (coffea arabica) were explored as enhancers of the solar photo-Fenton process to eliminate acetaminophen, sulfamethoxazole, carbamazepine, and diclofenac. The process performance, at pH 6.2 and 5 mg L− 1 of iron without the extracts, has a very limited action (~ 35% of the pollutants degradation at 90 min of treatment) due to the iron precipitation. Interestingly, the extracts addition increased the soluble iron forms but only copoazu extract improved the pollutants degradation (~ 95% of elimination at 90 min of the process action). The copoazu extract acted as a natural complexing agent, maintaining the soluble iron up to 2 mg L− 1 even after 90 min, and consequently enhancing the pollutants degradation. The effect of copoazu extract dose on the process performance was also assessed, finding that an iron: copoazu extract molar ratio equal to 1:0.16 was the most favorable condition. Then, the process improved by copoazu extract was applied to municipal wastewater. Remarkably, the process led to ~ 90% of total pharmaceuticals degradation at 20 min of treatment. This work evidences the feasibility of amazonian fruits extracts to improve the solar photo-Fenton process to degrade pharmaceuticals in aqueous matrices at near-neutral pH.

show abstract

Elimination of representative fluoroquinolones, penicillins, and cephalosporins by solar photo-Fenton: degradation routes, primary transformations, degradation improvement by citric acid addition, and antimicrobial activity evolution

Cited by 30 publications

References 76 publications

Evaluation of residual antimicrobial activity and acute toxicity during the degradation of gatifloxacin by ozonation

Evaluation of residual antimicrobial activity and acute toxicity during the degradation of gatifloxacin by ozonation

Improvement of solar photo-Fenton by extracts of amazonian fruits for the degradation of pharmaceuticals in municipal wastewater

Improvement of Solar Photo-Fenton by Extracts of Amazonian Fruits for the Degradation of Pharmaceuticals in Municipal Wastewater

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