Elimination of physiological senescent cutaneous cells in a novel p16‐dependent senolytic mouse model impacts lipid metabolism in skin aging
Yuma Sugiyama,
Yoichiro Kawabe,
Tanenobu Harada
et al.
Abstract:The evidence of the correlation between cellular senescence and aging has increased in research with animal models. These models have been intentionally generated to target and regulate cellular senescent cells with the promoter activity of p16Ink4a or p19Arf, genes that are highly expressed in aging cells. However, the senolytic efficiency in various organs and cells from these models represents unexpected variation and diversity in some cases. We have generated a novel knock‐in model, p16tdT‐hDTR mice, which… Show more
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