Elimination of Photon Quenching by a Transition Layer to Fabricate a Quenching‐Shield Sandwich Structure for 800 nm Excited Upconversion Luminescence of Nd<sup>3+</sup>‐Sensitized Nanoparticles

Zhong, Yongwang; Gan, Tian; Gu, Zhennan; Yang, Yijun; Gu, Lin; Zhao, Yuliang; Ma, Ying; Yao, Jiannian

doi:10.1002/adma.201304903

Cited by 415 publications

(336 citation statements)

References 47 publications

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“…The results not only indicated 125 times stronger upconverted luminescence from Nd 3+ ‐doped UCNPs compared with conventional 980 nm‐excited UCNPs but also minimized overheating issues and resulted in deeper tissue penetration ( Figure 15 ). 55 Lin and co‐workers extended usage of 808 nm excited Nd 3+ ‐doped UCNPs to successfully target cancer tumor; this is an important step towards anti‐cancer chemotherapy and biological imaging applications without detrimental overheating problems 173…”

Section: Effects Of Nir Light Power Intensity On the Upconverting Phementioning

confidence: 99%

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

et al. 2016

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The development of drug delivery systems (DDSs) using near infrared (NIR) light and upconversion nanoparticles (UCNPs) has generated intensive interest over the past five years. These NIR‐initiated DDSs not only offer a high degree of spatial and temporal determination of therapeutic release but also provide precise control over the released dosage. Furthermore, these nanoplatforms confer several advantages over conventional light‐based DDSs—NIR offers better tissue penetration depth and a reduced risk of cellular photo‐damage caused by exposure to light at high‐energy wavelengths (e.g., ultraviolet light, <400 nm). The development of DDSs that can be activated by low intensity NIR illumination is highly desirable to avoid exposing living tissues to excessive heat that can limit the in vivo application of these DDSs. This encompasses research in three directions: (i) enhancing the quantum yield of the UCNPs; (ii) incorporation of photo‐responsive materials with red‐shifted absorptions into the UCNPs; and (iii) tuning the UCNPs excitation wavelength. This review focuses on recent advances in the development of NIR‐initiated DDS, with emphasis on the use of photo‐responsive compounds and polymeric materials conjugated onto UCNPs. The challenges that limit UCNPs clinical applications, alongside with the aforementioned techniques that have emerged to overcome these limitations, are highlighted.

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Section: Effects Of Nir Light Power Intensity On the Upconverting Phementioning

confidence: 99%

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

et al. 2016

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“…Several groups spatially separated activators from Nd 3+ ions via core-shell structures to acquire high efficient luminescence under excitation at 800 nm. [16][17][18][19] Although the upconversion luminescence (UCL) caused by a thick Nd 3+ sensitizing shell could be used for bioimaging, this structure is not appropriate for FRET-based applications, such as homogeneous bioassays, biosensing and PDT, which are in general based on an energy transfer mechanism. For example, for UCNP-based PDT, the luminescence activators inside the nanoparticles (as the energy donors) transfer the excitation energy to the acceptors, i.e.…”

Section: Introductionmentioning

confidence: 99%

808 nm driven Nd³⁺-sensitized upconversion nanostructures for photodynamic therapy and simultaneous fluorescence imaging

et al. 2015

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UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). UvA-DARE (Digital AcademicRepository Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. The in vivo biological applications of upconversion nanoparticles (UCNPs) prefer excitation at 700-850 nm, instead of 980 nm, due to the absorption of water. Recent approaches in constructing robust Nd 3+ doped UCNPs with 808 nm excitation properties rely on a thick Nd 3+ sensitized shell.However, for the very important and popular Förster resonance energy transfer (FRET)-based applications, such as photodynamic therapy (PDT) or switchable biosensors, this type of structure has restrictions resulting in a poor energy transfer. In this work, we have designed a NaYF 4 :Yb/Ho@NaYF 4 :Nd@NaYF 4 core-shell-shell nanostructure. We have proven that this optimal structure balances the robustness of the upconversion emission and the FRET efficiency for FRET-based bioapplications. A proof of the concept was demonstrated for photodynamic therapy and simultaneous fluorescence imaging of HeLa cells triggered by 808 nm light, where low heating and a high PDT efficacy were achieved.

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“…2b). [48][49][50][51] . The results show that even a relatively low doping level (3%) can cause more rapid rise and decay properties (Fig.…”

Section: Please Do Not Adjust Marginsmentioning

confidence: 99%

Phase angle encoded upconversion luminescent nanocrystals for multiplexing applications

et al. 2017

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Lanthanide-doped upconversion nanoparticles (UCNPs) are increasingly used as luminescent candidates in multiplexed applications due to their excellent optical properties. Inthepast,several encodingidentities havebeen proposedforUCNPs,includingemissioncolour,intensity ratio between different emissionbands, colourspatial distribution, and luminescencelifetime.In this paper, a new optical encoding dimension for upconversion nanomaterials is developed by exploring their luminescence kinetics, i.e., the phase angle of upconversion luminescence in response to a harmonic-wave excitation. Our theoretical derivation shows that the phase angle is governed jointly by the rise and decay times, characterizing the upconversion luminescence kinetics. Experimentally, a full set of methods are developed to manage the upconversion luminescence kinetics, through which the rise and decay times can be manipulated dependently or independently. Furthermore,a large phase-angle space is achieved in which tens of unique codes can be potentially generated in the same colour channel. Our work greatly extends the multiplexing capacity of UCNPs,and offers newopportunities for their applicationsin a wide range such as microarray assays, bioimaging, anti-counterfeiting, deep tissue multiplexed labelling/detectionand high-density data storage.In addition, the development of thisluminescence kinetics-based optical encoding strategy is also instructive for developing multiplexing techniques using other cascade luminescent systems that inherently lack multi-spectral channels, such as triplet-triplet annihilation molecule pairs.

QC 20170330

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Elimination of Photon Quenching by a Transition Layer to Fabricate a Quenching‐Shield Sandwich Structure for 800 nm Excited Upconversion Luminescence of Nd³⁺‐Sensitized Nanoparticles

Cited by 415 publications

References 47 publications

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

808 nm driven Nd³⁺-sensitized upconversion nanostructures for photodynamic therapy and simultaneous fluorescence imaging

Phase angle encoded upconversion luminescent nanocrystals for multiplexing applications

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Elimination of Photon Quenching by a Transition Layer to Fabricate a Quenching‐Shield Sandwich Structure for 800 nm Excited Upconversion Luminescence of Nd3+‐Sensitized Nanoparticles

Cited by 415 publications

References 47 publications

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

808 nm driven Nd3+-sensitized upconversion nanostructures for photodynamic therapy and simultaneous fluorescence imaging

Phase angle encoded upconversion luminescent nanocrystals for multiplexing applications

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Elimination of Photon Quenching by a Transition Layer to Fabricate a Quenching‐Shield Sandwich Structure for 800 nm Excited Upconversion Luminescence of Nd³⁺‐Sensitized Nanoparticles

808 nm driven Nd³⁺-sensitized upconversion nanostructures for photodynamic therapy and simultaneous fluorescence imaging