Elimination of oxacillin, its toxicity and antibacterial activity by using ionizing radiation

Takács, Erzsébet; Wang, Jianlong; Chu, Libing; Tóth, Tünde; Kovács, Krisztina; Bezsenyi, Anikó; Szabó, László; Homlok, Renáta; Wojnárovits, László

doi:10.1016/j.chemosphere.2021.131467

Cited by 14 publications

(6 citation statements)

References 41 publications

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“…The four β-lactam antibiotics in Table 1 , amoxicillin, oxacillin, cloxacillin, and piperacillin, have similar chemical structures [ 25 ]; their ThOD mg/mg values fall in a narrow range between 1.47 and 1.63. Since their COD meas /ThOD values are also close to each other (0.79–0.96), the COD meas /TOC meas ratios are also in a narrow range, with an average of 2.40.…”

Section: Resultsmentioning

confidence: 99%

Wastewater Characterization: Chemical Oxygen Demand or Total Organic Carbon Content Measurement?

Wojnárovits,

Homlok,

Kovács

et al. 2024

Molecules

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The long time (2 h) required for measurement, expensive chemicals (Ag2SO4), and toxic reagents (K2Cr2O7, HgSO4) limit the application of the standard method for measuring the oxygen equivalent of organic content in wastewater (chemical oxygen demand, COD). In recent years, the COD has increasingly been replaced by the total organic carbon (TOC) parameter. Since the limit values of the pollution levels are usually given in terms of the COD, efforts are being made to find the correlation between these parameters. Several papers have published correlation analyses of COD and TOC for industrial and municipal wastewater, but the relationship has not been discussed for individual chemicals. Here, this relationship was investigated using 70 contaminants (laboratory chemicals, pharmaceuticals, and pesticides). The calculated COD values, in most cases, agreed, within ~10%, with the experimental ones; for tetracyclines and some chloroaromatic molecules, the measured values were 20–50% lower than the calculated values. The COD/TOC ratios were between 2 and 3: for macrolides, they were ~3; for fluoroquinolones and tetracyclines, they were ~2. The molecular structure dependence of the ratio necessitates the establishing of the correlation on an individual basis. In advanced oxidation processes (AOPs), the ratio changes during degradation, limiting the application of TOC instead of COD.

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Section: Resultsmentioning

confidence: 99%

Wastewater Characterization: Chemical Oxygen Demand or Total Organic Carbon Content Measurement?

Wojnárovits,

Homlok,

Kovács

et al. 2024

Molecules

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“…Ionizing radiation has been demonstrated suitable for degradation of antibiotics at low doses [6,7,8]. However, in terms of mineralization TOC removal is less effective than organic pollutants removal since extremely high absorbed doses are needed for complete mineralization [10].…”

Section: Resultsmentioning

confidence: 99%

“…Takacs and coworkers (2021) evidenced that the oxacillin biodegradability is improved by γ-irradiation, producing non-toxic degradation products to microbes in a WWT plant. In addition, due to altering the bicyclic structure, elimination of antimicrobial activity was noted [7]. Tegze and coworkers (2021) showed > 99% removal of ciprofloxacin and norfloxacin at 2 kGy (8 kGy h -1 dose rate), demonstrating also that the degradation products had no antibacterial activity and that non-biodegradable antibiotics were transform to biodegradable ones [8].…”

Section: Figure 1: Molecular Structure Of Amoxicillinmentioning

confidence: 99%

Degradation and Toxicity of Amoxicillin After Electron Beam Irradiation

Borrely¹,

Redígolo²,

Villardi³

et al. 2022

Braz. J. Rad. Sci.

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A recent and growing concern in environmental studies is the presence of antibiotics in wastewater, which contributes to antimicrobial resistance building. Amoxicillin, according to the World Health Organization, is one of the most consumed antibiotics worldwide, for being a first line therapy for common infections. Among several drug degradation methodologies, electron beam irradiation (EBI) is presented as an efficient and green treatment. This work presents data on amoxicillin degradation via EBI. Ecotoxicity essays were performed employing Vibrio fischeri, carbon removal efficiency was evaluated by TOC and degradation rate by LC/MS-MS. Chromatographic results indicate a 97.9% drug concentration reduction after 0.75 kGy; TOC results indicate 10% carbon removal at 3.0 kGy; toxicity assays indicate 80% in removal of toxicity at 0.75 kGy and a decrease in efficiency with higher doses. In conclusion, results indicate the 0.75 kGy as most effective for drug removal employing EBI.

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“…Te spectra of the samples containing Oxa were compared with the spectrum of the standard solution, and the presence of a light absorption band in the UV-Vis spectrum below ∼260 nm is observed. Te band attributed to the amide n⟶π * transition in the β-lactam ring is present at 230 nm, and the band due to the aromatic π⟶π * transition is present as a shoulder around 270 [58]. Te band at 270 nm is found with the same intensity and at a slightly higher wavelength in the case of materials based on Car and Alg with BON or BOS.…”

Section: Uv-vis Analysis Of Final Dental Materials Te Spectrophotomet...mentioning

confidence: 87%

Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration

Budiul,

Vlase,

Negru

et al. 2024

Journal of Chemistry

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The aim of the present study was to formulate new variants of synthetic and animal-source bone materials coated with different biopolymers, containing antibiotics (ampicillin and oxacillin) and alendronate drugs. Validation consists in establishing mixtures that do not present interactions between components. These materials should act as a drug delivery system alongside the bone base. Natural polymers such as chitosan, alginate, and kappa-carrageenan have been shown to be optimal materials for drug delivery due to their intrinsic biocompatibility. Binary, ternary, and quaternary mixtures between components are analyzed by FT-IR spectroscopy, UV-Vis analysis, thermogravimetry (TGA), and scanning electron microscopy (SEM). The analysis led to the validation of materials suitable for the controlled release of active substances, which have the greatest chance of increasing the speed of bone regeneration, as well as helping in the local administration of antibiotics, which currently must be administered in the form of oral formulations or an injection. According to the FTIR, thermogravimetry, UV-Vis, SEM, and cytotoxicity tests performed in this study, it can be said that it is quite easy to obtain materials that can be used in dental practice that facilitate bone reconstruction through local treatment. At the same time, it was found that both active substances can be incorporated into the material together with Alg and Chit, thus limiting the adverse effects and maximizing the local beneficial effects.

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Elimination of oxacillin, its toxicity and antibacterial activity by using ionizing radiation

Cited by 14 publications

References 41 publications

Wastewater Characterization: Chemical Oxygen Demand or Total Organic Carbon Content Measurement?

Wastewater Characterization: Chemical Oxygen Demand or Total Organic Carbon Content Measurement?

Degradation and Toxicity of Amoxicillin After Electron Beam Irradiation

Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration

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