Elimination of Indocyanine Green in the Perioperative Evaluation of Donor Liver Function

Ms, Mandell; Wachs, Michael; Cu, Niemann; Tk, Henthorn

doi:10.1097/00000539-200211000-00010

Cited by 17 publications

(11 citation statements)

References 10 publications

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“…Patients with clinically poor graft function but normal hepatic arterial and portal vein flow as demonstrated by Doppler ultrasound sonography exhibited low ICGPDR values equivalent to recently published cut-off values indicating severe impairment [18,[22][23][24]33]. Baseline tyrosine plasma levels were severely elevated and tyrosine clearance delayed.…”

Section: Discussionsupporting

confidence: 54%

“…sporadic allergic reactions and no toxicity) and extremely low extrahepatic elimination [13,18,[22][23][24]. ICG clearance shows good correlation with overall liver function and has some predictive value for graft survival.…”

Section: Discussionmentioning

confidence: 96%

“…Furthermore, many of these standard indicators reflect the degree of cell damage caused by the procedure rather than the remaining metabolic capacity of the graft. Other methods have therefore been advocated in which hepatic metabolic function is assessed by measuring clearance from blood of substrates metabolized in the liver, such as sulfobromophthalein dyes, caffeine, galactose and/or in combination with cytochrome P450 activity, lignocaine and monoethylglycine xylidide (MEGX), or ICG [17][18][19][20][21][22][23][24][25][26]. Furthermore, various breath tests, usually using the stable isotope 13 C, have been evaluated for assessment of liver function [27][28][29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

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Nicht-Isotopen Tyrosin-Kinetik mit dem Dipeptid Alanyl-Tyrosin zur Beurteilung der Organfunktion bei Lebertransplantation – eine Pilotstudie

Krenn

Pokorny

Hoerauf

et al. 2008

Wien Klin Wochenschr

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nicht-Isotopen Tyrosin-Kinetik mit dem Dipeptid Alanyl-Tyrosin zur Beurteilung der Organfunktion bei Lebertransplantation – eine Pilotstudie

Krenn

Pokorny

Hoerauf

et al. 2008

Wien Klin Wochenschr

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“…Factors that influence hepatic blood flow can be further subdivided into local and systemic factors. A localised decrease in hepatosplanchnic blood flow, for example due to hepatic artery thrombosis or intra‐abdominal hypertension, decreases the elimination of ICG . Systemic haemodynamics that influence hepatosplanchnic perfusion (e.g.…”

Section: Liver Function Monitoring Using Icgmentioning

confidence: 99%

Green light for liver function monitoring using indocyanine green? An overview of current clinical applications

et al. 2014

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SummaryThe dye indocyanine green is familiar to anaesthetists, and has been studied for more than half a century for cardiovascular and hepatic function monitoring. It is still, however, not yet in routine clinical use in anaesthesia and critical care, at least in Europe. This review is intended to provide a critical analysis of the available evidence concerning the indications for clinical measurement of indocyanine green elimination as a diagnostic and prognostic tool in two areas: its role in peri-operative liver function monitoring during major hepatic resection and liver transplantation; and its role in critically ill patients on the intensive care unit, where it is used for prediction of mortality, and for assessment of the severity of acute liver failure or that of intra-abdominal hypertension. Although numerous studies have demonstrated that indocyanine green elimination measurements in these patient populations can provide diagnostic or prognostic information to the clinician, 'hard' evidence -i.e. high-quality prospective randomised controlled trials -is lacking, and therefore it is not yet time to give a green light for use of indocyanine green in routine clinical practice.

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“…Tests that measure hepatic function such as indocyanine green (ICG) (16) and lidocaine metabolism (15,17) are influenced by multiple factors and results are inconsistent. Blood metabolomics is a functional test that is able to monitor several metabolic pathways simultaneously (6).…”

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confidence: 99%

Early Detection of Graft Failure Using the Blood Metabolic Profile of a Liver Recipient

et al. 2007

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In this case report we describe the blood metabolic profile ("metabolomics") by nuclear magnetic resonance (NMR) spectroscopy and principle component analysis (PCA) from a patient who underwent two consecutive liver transplantations. The first graft from a living-related donor failed and was followed by a second successful transplant from a deceased donor. Using quantitative high-resolution H-NMR spectroscopy, 48 endogenous metabolites were analyzed in whole blood samples at baseline and different time points after each transplantation. From 48 analyzed metabolites, six metabolites were identified by PCA as metabolic markers consistent with a non-functional liver after first transplantation. Importantly, this distinctive metabolic profile was present as early as two hours after first transplant surgery when no other variable or conventional laboratory tests indicated poor graft function. This article reports the potential usefulness of quantitative H-NMR based metabolomics to diagnose early graft dysfunction in liver transplantation.

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Elimination of Indocyanine Green in the Perioperative Evaluation of Donor Liver Function

Abstract: The authors describe the intraoperative use of indocyanine green dye elimination to detect critical reductions in donor liver function.

Cited by 17 publications

References 10 publications

Nicht-Isotopen Tyrosin-Kinetik mit dem Dipeptid Alanyl-Tyrosin zur Beurteilung der Organfunktion bei Lebertransplantation – eine Pilotstudie

Nicht-Isotopen Tyrosin-Kinetik mit dem Dipeptid Alanyl-Tyrosin zur Beurteilung der Organfunktion bei Lebertransplantation – eine Pilotstudie

Green light for liver function monitoring using indocyanine green? An overview of current clinical applications

Early Detection of Graft Failure Using the Blood Metabolic Profile of a Liver Recipient

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