Elimination of hexamethylene diisocyanate cross-linked polypeptides in patients with normal or impaired renal function

Köhler, Hans; Kirch, Wilhelm; Fuchs, P. M.; Stalder, Karlheinz; Distler, A.

doi:10.1007/bf00716381

Cited by 13 publications

(3 citation statements)

References 9 publications

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“…As others [17],we have observed that the elimination half-life ofHaemaccel calculated from plasma hydroxyproline concentrations was about 13 h. Free Haemaceel is filtered through the kidney, but only 50% are recovered in urine collected during 48 h [17]. Other clearance mechanisms must thus operate, particularly for Haemaccel-fibronectin complexes.…”

Section: Gel Filtration Chromatographymentioning

confidence: 51%

“…They are mainly composed of polymerized polypeptides derived from degraded gelatin. Their mean molecular weight is 35 000 [17]. Increasing amounts of Haemaccel, of Geloplasma or of gelatin (final concentrations ranging between 10 flg and 5 mg) were incubated with the reference plasma for I h or 6 days at 37°C.…”

Section: In-vitro Inhibition Of the Gelatin-bc Offibronectin By Haemamentioning

confidence: 99%

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In‐vivo studies on Haemaccel‐fibronectin interaction in man

Damas

Adam

Buret

et al. 1987

Eur J Clin Investigation

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An enzyme-linked immunoassay has been recently set up for direct measurement of the binding capacity of plasma fibronectin to gelatin. This binding capacity could be completely inhibited in vitro by an eight-fold excess of gelatin, of Haemaccel, but not of Geloplasma. On the contrary, the levels of immunoreactive fibronectin measured by laser nephelometry did not change, in presence of 10 to 1000 micrograms ml-1 of gelatin, of Haemaccel or of Geloplasma. When infused into normal volunteers, Haemaccel provoked a strong and immediate inhibition of the plasma fibronectin binding capacity to gelatin. This inhibition was dose-dependent and maximal after infusion of 500 ml of Haemaccel. Twenty-four hours after this infusion, there was a progressive recovery of the gelatin-binding capacity, which was almost completely achieved 96 h later. The formation of complexes between Haemaccel and fibronectin was demonstrated by gel filtration chromatography and by affinity chromatography. Immunoreactive plasma fibronectin levels remained unchanged up to 24 h after infusion of 500 ml of Haemaccel. A transient decline to 50% of its initial value then occurred the second day after the infusion. Therefore, a delay existed between the formation of fibronectin-Haemaccel complexes and their elimination from the bloodstream. This delay decreased when smaller volumes of Haemaccel were infused, which strongly suggests that plasma fibronectin is cleared by means of Haemaccel and does not seem to play a role of opsonin in these conditions.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Gel Filtration Chromatographymentioning

confidence: 51%

Section: In-vitro Inhibition Of the Gelatin-bc Offibronectin By Haemamentioning

confidence: 99%

In‐vivo studies on Haemaccel‐fibronectin interaction in man

Damas

Adam

Buret

et al. 1987

Eur J Clin Investigation

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“…29 Newgeneration gelatins are rapidly eliminated from the body mainly by glomerular filtration, with about 71% elimination in urine by 24 hours and a very less amount is metabolized. 30 This shows that polygeline does not accumulate in patients with renal failure. Hence, laboratory indicators of renal functions were not measured in this study.…”

mentioning

confidence: 92%

Polygeline in patients with hypovolemia caused by accidental trauma: a prospective, multicentric, safety study

et al. 2018

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Background: Objective of present study was to evaluate the safety of polygeline (Haemaccel®) and its effect on vital sign parameters in patients with hypovolemia caused by accidental trauma.Methods: Adverse drug reactions (ADRs) of polygeline within 6 hours after administration, and the effect of polygeline infusion on vital sign parameters, in trauma patients hospitalized at the emergency department, were evaluated in this prospective, multicentric, post-marketing observational study.Results: One hundred forty patients (men: 81.4%; women: 18.6%), with a mean (±standard deviation) age of 33.7±10.6 years, were enrolled. At the time of admission, mean blood volume loss was 1400.1±558.8ml, with 86.4% patients reporting blood volume loss of >15%; 49.3% patients presented with class-II hypovolemia. No ADRs or any unusual clinically significant changes were reported within 6 hours of polygeline administration. All vital parameters (blood pressure and pulse rate) significantly improved at 1 hour of polygeline administration; this trend was sustained until 6 hours (p<0.001). Reduction in respiratory rate was significant at 1 and 6 hours versus baseline (p<0.001). Urine output and central venous oxygen saturation also showed significant improvement at 1 and 6 hours after treatment initiation (p<0.001). Arterial pH and mean blood lactate levels also showed a significant change from the baseline (p<0.05) at both 1 and 6 hours.Conclusions: Polygeline was found to be safe and effective in improving hemodynamic stability in patients with hypovolemia due to accidental trauma.

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Elimination und Wirkung von kolloidalen Plasmaersatzmitteln

Köhler

1979

Verhandlungen Der Deutschen Gesellschaft Für Innere Medizin

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Elimination of hexamethylene diisocyanate cross-linked polypeptides in patients with normal or impaired renal function

Cited by 13 publications

References 9 publications

In‐vivo studies on Haemaccel‐fibronectin interaction in man

In‐vivo studies on Haemaccel‐fibronectin interaction in man

Polygeline in patients with hypovolemia caused by accidental trauma: a prospective, multicentric, safety study

Elimination und Wirkung von kolloidalen Plasmaersatzmitteln

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