Elimination of healthcare-associated Acinetobacter baumannii infection in a highly endemic region

Ergönül, Önder; Tokça, Gizem; Keske, Şiran; Dönmez, Ebru; Madran, Bahar; Kömür, Azize; Gönen, Mehmet; Can, Füsun

doi:10.1016/j.ijid.2021.10.011

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…Gram negative pathogens were the most common cause (72.5%) of secondary infections and carbapenem resistance rate was 62.1% 22 . In our hospital, Acinetobacter baumannii infections were eliminated 23 , although A. baumannii infections are common in the geographical region. In our study, only two patients in the control group had A. baumannii infections.…”

Section: Discussionmentioning

confidence: 88%

COVID-19 associated bacterial infections in intensive care unit: a case control study

Kaçmaz,

Keske,

Sişman

et al. 2023

Sci Rep

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We described the secondary bacterial infections (SBI) among COVID-19 patients in comparison with non-COVID-19 patients. We performed a retrospective case–control study between January 01, 2020 and April 01, 2022. Including the adult patients, who stayed ≥ 72 h in intensive care unit (ICU). In total 405 patients were included, 135 had (33.3%) COVID-19, with similar age and gender. The length of stay in ICU was not different (11.4 vs 8.2, p = 0.109), however mean intubation days were higher among COVID-19 cases (6.5 vs 3.8, p = 0.005), SBI were more common among COVID-19 cases (34% vs 10.7%, p < 0.001). Among the patients with pneumonia, the rate of gram-positive bacteria was higher in COVID-19 group than the control group (39% vs 5%, p = 0.006). The predictors for SBI were having COVID-19 (OR: 2.3, Cl 1.25–4.32, p = 0.008), days of intubation (OR: 1.05, Cl 1.01–1.10, p = 0.004), and being male (OR: 2, Cl 1.12–3.58, p = 0.018). The predictors of mortality were COVID-19 (OR: 2.38, Cl 1.28–4.42, p = 0.006), days of intubation (OR: 1.06, Cl 1.03–1.09, p < 0.001), active hematologic malignancy (OR: 3.1, Cl: 1.33–7.28, p = 0.09), active solid tumors (OR: 2.44, Cl 1.21–4.91, p = 0.012), and coronary artery diseases (OR: 1.8, Cl 1.01–3.52, p = 0.045). The most common SBI in COVID-19 patients were methicillin-sensitive Staphylococcus aureus. No carbapenem-resistant Enterobacterales related infections were detected in COVID-19 patients.

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Section: Discussionmentioning

confidence: 88%

COVID-19 associated bacterial infections in intensive care unit: a case control study

Kaçmaz,

Keske,

Sişman

et al. 2023

Sci Rep

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“…Environmental contamination has a critical role in the spread of nosocomial infections 28,29 . A different study has shown that screening surroundings and medical devices for possible sources during outbreaks were beneficial 30 . In our study, environmental sampling was performed for surveillance because of an increase in A. baumannii infections with similar susceptibility patterns to existing antibiotics.…”

Section: Discussionmentioning

confidence: 99%

The association between Acinetobacter baumannii infections and the COVID-19 pandemic in an intensive care unit

Boral

Genç

Pınarlık

et al. 2022

Sci Rep

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We aimed to describe the increased rate of Acinetobacter baumannii infections during the COVID-19 pandemic and define its significance within the last five years. This study was performed in a tertiary hospital with 280 beds and included all patients infected with A. baumannii in the intensive care unit between January 1, 2018, and June 30, 2022. A. baumannii-infected patients in the intensive care unit 27 months before the pandemic and 27 months during the pandemic were included. Pulsed-field gel electrophoresis was performed to assess clonal relatedness. The infection control measures were specified based on the findings and targeted elimination. In total, 5718 patients were admitted to the intensive care unit from January 1st, 2018, to June 30th, 2022. A. baumannii infection was detected in 81 patients. Compared to the pre-pandemic era, the rate of A. baumannii infection during the pandemic was 1.90 times higher (OR: 1.90, 95% CI: [1.197, 3.033]). Clonality assessment of multidrug-resistant A. baumannii samples revealed eight clusters with one main cluster comprising 14/27 isolates between 2021 and 2022. The case fatality rate of the pre-pandemic and pandemic era was not different statistically (83.33% vs. 81.48%, p = 0.835). Univariate analysis revealed the association of mechanical ventilation (p = 0.002) and bacterial growth in tracheal aspirate (p = 0.001) with fatality. During the COVID-19 pandemic, potential deficits in infection control measures may lead to persistent nosocomial outbreaks. In this study, the introduction of enhanced and customized infection control measures has resulted in the containment of an A. baumannii outbreak.

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“…1,2 These infections can be caused by various pathogenic bacteria, including Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, significantly impacting human health. 3,4 Staphylococcus aureus (S. aureus) is a common bacterium that can cause a range of infections, from minor skin and soft tissue to severe bloodstream infections. 5,6 It is a leading cause of HAIS and is known for its ability to develop resistance to multiple antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Disinfectant Potential of Plant Extracts against Bacterial Strains

2024

TJNPR

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The massive and excessive use of disinfectants has harmful effects on ecosystems and human health. This study aimed to evaluate the potential effect of the methanol extracts of Peganum harmala, Pistacia lentiscus, Rubia tinctorum, and Nardostachys grandiflora. Antimicrobial activity was tested against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, and Pseudomonas aeruginosa ATCC 27853, the disinfectant potential was determined using the dilution-neutralization method (NF EN1040/ T72-152, 2006). A phytochemical assay was carried out on plant extracts employing the Folin-Ciocalteu method for the quantification of polyphenols, and the aluminum chloride method (AlCl3) was used to determine the flavonoid content. The results revealed the antimicrobial activity of Peganum harmala against all the strains, with a minimum inhibitory concentration (MIC) between 1 and 4 mg/mL, followed by Pistacia lentiscus and Rubia tinctorum, with MICs between 2 and 16 and 4 and 16 mg/ml, respectively. However, only Peganum harmala showed significant disinfectant activity, with microbial reduction ranging from 4.66 log10 CFU/mL to 3.19 log10 CFU/mL after 5 minutes of contact. The phytochemical assay revealed a flavonoid content of 79 ± 2.5 μg eq Que/mg E and a phenol content of 72 ± 0.88 μg eq AG/mg E in Peganum harmala. Peganum harmala has significant potential as a natural disinfectant. Further research should focus on the development of eco-friendly and cost-effective disinfection methods. This would help mitigate the negative impacts of chemical disinfectants on ecosystems and human health.

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Elimination of healthcare-associated Acinetobacter baumannii infection in a highly endemic region

Cited by 6 publications

References 10 publications

COVID-19 associated bacterial infections in intensive care unit: a case control study

COVID-19 associated bacterial infections in intensive care unit: a case control study

The association between Acinetobacter baumannii infections and the COVID-19 pandemic in an intensive care unit

Exploring the Disinfectant Potential of Plant Extracts against Bacterial Strains

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