Elimination and strengthening of glycinergic/GABAergic connections during tonotopic map formation

G, Kim; Kandler, Karl

doi:10.1038/nn1015

Cited by 219 publications

(294 citation statements)

References 46 publications

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“…Auditory cortical IRFs were far more heterogeneous and irregular than those described for the auditory nerve, which shows the opposite trend of bandwidth changes with age (25). Moreover, the auditory nerve and brainstem mature very early in the course of development compared with what we observed in the cortex (25)(26)(27)(28)(29).…”

Section: Discussioncontrasting

confidence: 45%

Development of spectral and temporal response selectivity in the auditory cortex

Chang

Bao²,

Imaizumi³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

149

160

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The mechanisms by which hearing selectivity is elaborated and refined in early development are very incompletely determined. In this study, we documented contributions of progressively maturing inhibitory influences on the refinement of spectral and temporal response properties in the primary auditory cortex. Inhibitory receptive fields (IRFs) of infant rat auditory cortical neurons were spectrally far broader and had extended over far longer duration than did those of adults. The selective refinement of IRFs was delayed relative to that of excitatory receptive fields by an Ϸ2-week period that corresponded to the critical period for plasticity. Local application of a GABA A receptor antagonist revealed that intracortical inhibition contributes to this progressive receptive field maturation for response selectivity in frequency. Conversely, it had no effect on the duration of IRFs or successive-signal cortical response recovery times. The importance of exposure to patterned acoustic inputs was suggested when both spectral and temporal IRF maturation were disrupted in rat pups reared in continuous, moderate-intensity noise. They were subsequently renormalized when animals were returned to standard housing conditions as adults.

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Section: Discussioncontrasting

confidence: 45%

Development of spectral and temporal response selectivity in the auditory cortex

Chang

Bao²,

Imaizumi³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

149

160

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“…Afferent and efferent connections of the MNTB are also changing during this age (Kandler and Friauf 1993;Kim and Kandler 2003;Kuwabara et al 1991), which is the age used for patch-clamp studies. If indeed some MNTB principal cells do receive multiple calyces, it will be important to determine whether this is a transitory phenomenon during development like that seen in the other instances of strong single inputs or whether it persists in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Multiple Large Inputs to Principal Cells in the Mouse Medial Nucleus of the Trapezoid Body

Bergsman¹,

Camilli²,

McCormick³

2004

Journal of Neurophysiology

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The calyx of Held is a giant nerve terminal that forms a synapse directly onto the principal cells of the medial nucleus of the trapezoid body (MNTB) in the mammalian auditory brain stem. This central synapse, which is involved in sound localization, has become widely used for studying synaptic transmission. Anatomical studies of this nucleus have indicated that each principal cell is innervated by only one calyx. Here we use previously established electrophysiological criteria of excitatory postsynaptic current amplitude, kinetics, and transmitter type, as well as other characteristics commonly reported for this synapse, to examine the input properties of principal neurons. Our findings indicate that some principal cells receive more than one strong excitatory input. These inputs meet previously established electrophysiological criteria for identification as calyceal nerve terminals. Implications for the execution and analysis of experiments to avoid errors due to such multiple inputs are discussed.

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“…In adults, it receives tonotopically organized excitatory inputs from the ipsilateral cochlear nucleus and inhibitory inputs from the contralateral side via the medial nucleus of the trapezoid body (MNTB). The topography of the MNTB-LSO projection becomes refined during development (Sanes and Siverts, 1991;Sanes et al, 1992;Kim and Kandler, 2003) and thus serves as a model system for studying the development of inhibitory circuits. Gunsoo Kim will present his evidence from Karl Kandler's laboratory supporting the idea that cochlea-generated spontaneous activity is crucial for the topographic refinement of the MNTB-LSO pathway.…”

Section: Inhibitory Plasticity In Sensory Systemsmentioning

confidence: 99%

Developmental Plasticity of Inhibitory Circuitry

et al. 2006

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In 1949, Donald Hebb proposed a mechanism for use-dependent synaptic plasticity, suggesting that input neurons that reliably activate their postsynaptic target will strengthen their connections (Hebb, 1949). Since then, studies of use-dependent plasticity during development have been almost entirely focused on excitatory synapses, particularly those incorporating NMDA receptors (NMDARs). Neural circuits depend heavily on inhibition, however. Although there have been several in vitro studies of possible synaptic mechanisms underlying inhibitory plasticity Alger, 1992, 1994;Komatsu, 1994;Kano, 1995;Zilberter, 2000;Kreitzer and Regehr, 2001;Wilson and Nicoll, 2001;Kilman et al., 2002;Maffei et al., 2006), little is known at the systems level about use-dependent plasticity of inhibitory synapses. The realization that "inhibitory" neurotransmitters often depolarize immature neurons (Ben-Ari, 2002) further complicates the picture. This issue is important because clinical treatments for epilepsy, sensory dysfunction, or brain damage need to be informed by an understanding of both excitatory and inhibitory components of the circuits they are aimed at influencing. This mini-symposium, presented at the 36th Annual Meeting of the Society for Neuroscience, will address the roles and mechanisms of inhibitory synaptic plasticity during development of the mammalian CNS, using primarily in vivo approaches to examine circuit-level plasticity in a wide array of model systems. The goal of the mini-symposium is to bring this important research area into the spotlight and to encourage other investigators to participate in developing a better understanding of this underappreciated issue. Inhibitory plasticity in motor systemsThe transient presence of episodic bursts of spontaneous network activity (SNA) is observed throughout the developing CNS. In the spinal cord, SNA is important for axon guidance, motoneuron survival, neurochemical expression, and joint and muscle development . Despite its importance, the role of SNA in the maturation of spinal connectivity is poorly understood. In the laboratory of Peter Wenner, co-chair of the mini-symposium, postdoctoral fellow Carlos Gonzalez-Islas has been investigating the role of SNA in homeostatic plasticity within the embryonic chick spinal cord. Despite significant developmental challenges to the production of SNA, it is clear that the network is capable of maintaining its activity levels (Chub and O'Donovan, 1998). Wenner and Gonzalez-Islas hypothesized that SNA is maintained through compensatory changes in synaptic strength. To test this hypothesis, they reduced network activity with lidocaine for 2 d in ovo. This increased the strength of both glutamatergic synapses and immature, depolarizing GABAergic synapses (Gonzalez-Islas and Wenner, 2006) and accelerated the modulation of GABAergic synaptic strength normally observed between episodes of SNA. Together, these compensatory responses appeared to increase the excitability of the embryonic spinal cord in an attempt to maintain approp...

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Elimination and strengthening of glycinergic/GABAergic connections during tonotopic map formation

Cited by 219 publications

References 46 publications

Development of spectral and temporal response selectivity in the auditory cortex

Development of spectral and temporal response selectivity in the auditory cortex

Multiple Large Inputs to Principal Cells in the Mouse Medial Nucleus of the Trapezoid Body

Developmental Plasticity of Inhibitory Circuitry

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