Elimination and Prevention of Microbial Colonization of Central Venous Catheters Using Antibiotic Lock Technique and NonLeachable Form of Catheter Surface Incorporated Antibiotic by Gamma Radiation

Farrag, Hala A.; Hosny, Alaa El-Dien M.S.; Ali, Amr El Hag; Hagras, Soheir A. A.

doi:10.9790/3008-09152833

Cited by 1 publication

(2 citation statements)

References 35 publications

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“…Modification of the radiation grafted copolymer, PU-g-(AAc-co-GMA), was performed via the ring opening reaction with cefepime (NODCAR, Egypt), this was performed through refluxing with a super saturated solution of cefepime in methanol at 45°C for 1.5 h, the treated catheter segments were then washed, dried, and re-weighed (Farrag et al, 2014).…”

Section: Modification Of Graft Copolymer With Cefepimementioning

confidence: 99%

“…Briefly, segments (2 mm × 5 mm) were placed in a heavy microbial suspension (10 8 CFU/ml) of the tested strain, and aerobically incubated at 37°C. Bacterial cultures were replaced continuously every 48 h for a period of 30 days (Farrag et al, 2014). The extent of in-vitro biofilm formation was assessed every five days by the spread plate technique (Sanders, 2012) using unprocessed polymer as a control.…”

Section: Detection Of the Antibiofilm Characteristics Of The Modifiedmentioning

confidence: 99%

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In-vitro evaluation of antibacterial and antibiofilm efficiency of radiation-modified polyurethane–ZnO nanocomposite to be used as a self-disinfecting catheter

Hosny

Farrag

Helmy

et al. 2020

Journal of Radiation Research and Applied Sciences

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In the era of antibiotic resistance, antimicrobial polymers represent state of the art innovation evolved to fight biofilm-associated infections. In the present study, novel self-disinfecting polyurethane (PU) catheter materials were developed. Gamma radiation-induced graft copolymerization was used to functionalize PU using acrylic acid-co-glycidyl methacrylate (AAc/GMA) binary comonomer. The grafted PU, PU-g-(AAc-co-GMA), was subsequently modified by covalent immobilization of cefepime and/or wet in-situ intermatrix synthesis of ZnO (NPs) to produce PU-g-(AAc-co-GMA)/cefepime, PU-g-(AA-co-GMA-cefepime/ZnO and PU-g-(AAc-co-GMA)/ZnO nanocomposites, respectively. Modified polymers were characterized by Fourier transform infrared spectroscopy (FTIR), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and scanning electron microscope (SEM). Finally, the antibacterial and antibiofilm characteristics were evaluated against five multidrug-resistant (MDR) clinical bacterial isolates; including Gram-positive and Gram-negative microorganisms. FTIR confirmed the successful grafting and subsequent immobilization of cefepime. Formation of ZnO was verified by EDX analysis, while XRD analysis revealed the crystalline nature of ZnO NPs with a size range of 43-62 nm. Moreover, SEM showed the morphology, particle size and distribution of ZnO NPs within the prepared nanocomposites. The modified PU catheter nancomposites with or without cefepime showed excellent antibacterial and anti-biofilm characteristics. The prepared polymeric biocides could be potential candidates in medical care to combat biofilm formation on biomaterials.

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Section: Modification Of Graft Copolymer With Cefepimementioning

confidence: 99%

Section: Detection Of the Antibiofilm Characteristics Of The Modifiedmentioning

confidence: 99%

In-vitro evaluation of antibacterial and antibiofilm efficiency of radiation-modified polyurethane–ZnO nanocomposite to be used as a self-disinfecting catheter

Hosny

Farrag

Helmy

et al. 2020

Journal of Radiation Research and Applied Sciences

Self Cite

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show abstract

Elimination and Prevention of Microbial Colonization of Central Venous Catheters Using Antibiotic Lock Technique and NonLeachable Form of Catheter Surface Incorporated Antibiotic by Gamma Radiation

Abstract: Aim: To test the efficacy of antibiotic lock technique (ALT) and catheter material modification for the eradication and prevention of biofilm formation on central venous catheters (CVCs

Cited by 1 publication

References 35 publications

In-vitro evaluation of antibacterial and antibiofilm efficiency of radiation-modified polyurethane–ZnO nanocomposite to be used as a self-disinfecting catheter

In-vitro evaluation of antibacterial and antibiofilm efficiency of radiation-modified polyurethane–ZnO nanocomposite to be used as a self-disinfecting catheter

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