has disclosed that she is a member of the speakers' bureau for Sanofi Pasteur. This commentary does not contain a discussion of an unapproved/ investigative use of a commercial product/device.
AbstractNosocomial infections cause significant morbidity and mortality in neonatal intensive care unit (NICU) patients. Neonates, particularly those who are preterm and low birthweight, are at higher risk of acquiring infections compared with term and older infants. As a result, many interventions have been established in the NICU to attempt to decrease the infants' risk of acquiring infection. Over time, various interventions have been adopted as "standard of care," but other practices vary substantially from one unit to another. This review examines several infection prevention strategies used in the NICU and reviews the literature related to such practices. Evidence-based recommendations are made when supportive scientific evidence is available for this specific patient population.Objectives After completing this article, readers should be able to:1. Review evidence-based recommendations related to hand hygiene practices in the NICU. 2. Describe the appropriate use of personal protective equipment to protect the healthcare worker and infant from infectious pathogens. 3. Review evidence related to neonatal skin antisepsis for central venous catheter insertion. 4. Review the evidence supporting routine influenza and pertussis vaccination for NICU clinicians.