Eliminating molybdenum oxide interference in urine cadmium biomonitoring using ICP-DRC-MS

Jarrett, Jeffery M.; Xiao, Ge; Caldwell, Kathleen L.; Henahan, Dana; Shakirova, Gulchekhra; Jones, Robert L.

doi:10.1039/b801927d

Cited by 76 publications

(45 citation statements)

References 24 publications

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“…In accordance with the findings of Jarret et al (Jarrett et al, 2008), a direct relationship was found between urinary molybdenum concentration and the difference between the cadmium levels obtained using the standard and DRC methods, and a linear function was established (Figure 1).…”

Section: Resultssupporting

confidence: 69%

“…The evidence of adverse effects from excess molybdenum exposure is limited and it is generally believed to be of low toxicity (CDC, 2011). Jarret et al studied the influence of molybdenum interference on urinary cadmium measurements using NHANES data (Jarrett et al, 2008), and their findings were subsequently corrected and republished (CDC, 2011).…”

Section: E3s Web Of Conferencesmentioning

confidence: 99%

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Risk of overestimation of urinary cadmium concentrations: interference from molybdenum

Cañas

Esteban

Cutanda

et al. 2013

E3S Web of Conferences

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Abstract. We show here that the selection of analytical method is critical when measuring low levels of cadmium in human urine. Cadmium is today usually analyzed by Inductively Coupled Plasma Mass Spectrometry (ICP-MS), which has a higher sensitivity than Atomic Absorption Spectroscopy (AAS). ICP-MS cadmium measurements show interference from tin ( 114 Sn) and molybdenum oxides, which can result in an overestimation of cadmium levels. The 114Sn interference is stable and can be mathematically corrected. Molybdenum concentrations in urine are variable and different from individual to individual. We have estimated the degree of error which molybdenum interference introduces in the measurement of cadmium in urine by conventional ICP-MS. 268 urine samples from mothers and their children were measured. Removal of the molybdenum oxide interference (DRC-ICP-MS method) reduced urinary cadmium concentrations significantly (47.8%). The urinary molybdenum concentration in children was higher than in their mothers, resulting in greater overestimation. Our results clearly show that the DRC method is essential for reliable measurements of urinary cadmium concentrations, particularly in children. Furthermore, care should be taken when comparing Human Biomonitoring data for cadmium in urine and attention should be paid to which analytical method has been used (e.g. AAS and ICP-Ms), and especially if the measurements have been corrected for molybdenum interference.

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Section: Resultssupporting

confidence: 69%

Section: E3s Web Of Conferencesmentioning

confidence: 99%

Risk of overestimation of urinary cadmium concentrations: interference from molybdenum

Cañas

Esteban

Cutanda

et al. 2013

E3S Web of Conferences

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“…We obtained a mean of 6.42 (SD 0.38) µg/L (n=79), whereas the certified concentration mean was 6.57 (SD 0.07) µg/L. Following the methods by Jarrett et al, 33 urine cadmium concentrations were corrected for molybdenum oxide interference using the formula [ …”

Section: Urine Cadmium Determinationsmentioning

confidence: 99%

Cadmium Exposure and Incident Peripheral Arterial Disease

Téllez-Plaza

Güallar

Fabsitz

et al. 2013

Circ: Cardiovascular Quality and Outcomes

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Background-Cadmium has been associated with peripheral arterial disease (PAD) in cross-sectional studies, but prospective evidence is lacking. Our goal was to evaluate the association of urine cadmium concentrations with incident PAD in a large population-based cohort. Methods and Results-A prospective cohort study was performed with 2864 adult American Indians 45 to 74 years of age from Arizona, Oklahoma, and North and South Dakota who participated in the Strong Heart Study from 1989 to 1991 and were followed through 2 follow-up examination visits in 1993 to 1995 and 1997 to 1999. Participants were free of PAD, defined as an ankle brachial index <0.9 or >1.4 at baseline, and had complete baseline information on urine cadmium, potential confounders, and ankle brachial index determinations in the follow-up examinations. Urine cadmium was measured using inductively coupled plasma mass spectrometry and corrected for urinary dilution by normalization to urine creatinine. Multivariable-adjusted hazard ratios were computed using Cox-proportional hazards models for interval-censored data. A total of 470 cases of incident PAD, defined as an ankle brachial index <0.9 or >1.4, were identified. After adjustment for cardiovascular disease risk factors including smoking status and pack-years, the hazard ratio comparing the 80th to the 20th percentile of urine cadmium concentrations was 1.41 (1.05-1.81). The hazard ratio comparing the highest to the lowest tertile was 1.96 (1.32-2.81). The association persisted after excluding participants with ankle brachial index >1.4 only as well as in subgroups defined by sex and smoking status. Conclusions-Urine cadmium, a biomarker of long-term cadmium exposure, was independently associated with incident PAD, providing further support for cadmium as a cardiovascular disease risk factor. (Circ Cardiovasc Qual Outcomes. 2013;6:626-633.)

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“…This was probably because urinary cadmium levels were measured by inductively coupled plasma mass spectrometry (ICP-MS). In general, urine contains lots of molybdenum, which interferes with the measurement of cadmium by ICP-MS [4,5]. Therefore, the urinary cadmium levels of children reported in this study would be much higher than the true values.…”

mentioning

confidence: 71%

Biomonitoring of metal exposure in children in a northern city of Japan

Horiguchi

2015

Environ Health Prev Med

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Eliminating molybdenum oxide interference in urine cadmium biomonitoring using ICP-DRC-MS

Cited by 76 publications

References 24 publications

Risk of overestimation of urinary cadmium concentrations: interference from molybdenum

Risk of overestimation of urinary cadmium concentrations: interference from molybdenum

Cadmium Exposure and Incident Peripheral Arterial Disease

Biomonitoring of metal exposure in children in a northern city of Japan

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