ELIMAIA: A Laser-Driven Ion Accelerator for Multidisciplinary Applications

Margarone, D.; Cirrone, Giuseppe Antonio Pablo; Cuttone, G.; Amico, A.G.; Andò, L.; Borghesi, M.; Bulanov, Stepan; Bulanov, Sergei V.; Chatain, D.; Fajstavr, A.; Giuffrida, L.; Grepl, Filip; Kar, S.; Krása, J.; Kramer, Daniel; Larosa, G.; Leanza, R.; Levato, T.; Maggiore, M.; Manti, Lorenzo; Milluzzo, G.; Odlozilik, Boris; Olšovcová, Veronika; Perin, J. P.; Pipek, J.; Pšikal, J.; Petringa, Giada; Řídký, J.; Romano, F.; Rus, B.; Russo, A.; Schillaci, F.; Scuderi, V.; Velyhan, A.; Versaci, R.; Wiste, Tuomas E.; Zakova, M.; Korn, G.

doi:10.3390/qubs2020008

Cited by 58 publications

(50 citation statements)

References 59 publications

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“…Ref. [17] the use of flat scattering foils placed after the transport system has been proposed to deliver a transversal homogeneous dose over a sample with dimensions of clinical relevance (~cm 2 ) for future radiobiology studies at the ELIMED facility [18,19]. In other experiments, a sufficient transversal homogeneity was obtained by spreading the beam with the transport system itself.…”

Section: Introductionmentioning

confidence: 99%

Shaping of a laser-accelerated proton beam for radiobiology applications via genetic algorithm

2019

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A B S T R A C TLaser-accelerated protons have a great potential for innovative experiments in radiation biology due to the subpicosecond pulse duration and high dose rate achievable. However, the broad angular divergence makes them not optimal for applications with stringent requirements on dose homogeneity and total flux at the irradiated target. The strategy otherwise adopted to increase the homogeneity is to increase the distance between the source and the irradiation plane or to spread the beam with flat scattering systems or through the transport system itself. Such methods considerably reduce the proton flux and are not optimal for laser-accelerated protons. In this paper we demonstrate the use of a Genetic Algorithm (GA) to design an optimal non-flat scattering system to shape the beam and efficiently flatten the transversal dose distribution at the irradiated target. The system is placed in the magnetic transport system to take advantage of the presence of chromatic focusing elements to further mix the proton trajectories. The effect of a flat scattering system placed after the transport system is also presented for comparison. The general structure of the GA and its application to the shaping of a laser-accelerated proton beam are presented, as well as its application to the optimisation of dose distribution in a water target in air.

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Section: Introductionmentioning

confidence: 99%

Shaping of a laser-accelerated proton beam for radiobiology applications via genetic algorithm

2019

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“…Recently a unique user beamline ELIMAIA (ELI (Extreme Light Infrastructure) multidisciplinary applications of laser-ion acceleration) [9] has been installed at the ELI-Beamlines international user facility (Czech Republic). Its main goal is to deliver laser driven proton/ion beams both for basic laser-plasma acceleration physics and for multidisciplinary user applications, especially in the field of hadron-therapy or biomedical research [10].…”

Section: Introductionmentioning

confidence: 99%

“…A 3D rendering of the ELIMAIA beamline (Ion Accelerator + ELIMED) is shown in Figure 1. A complete description of ELIMAIA, including ELIMED, is reported in the literature [9]. The ion acceleration platform consists of a double plasma mirror chamber; a local laser diagnostics station; and an interaction chamber providing laser beam transport, pulse treatment, ion source generation, and in-situ ion and plasma characterization.…”

Section: Introductionmentioning

confidence: 99%

“…The ion acceleration platform consists of a double plasma mirror chamber; a local laser diagnostics station; and an interaction chamber providing laser beam transport, pulse treatment, ion source generation, and in-situ ion and plasma characterization. The ELIMED user application line will provide ion beam transport (permanent magnet quadrupoles, PMQs), energy selection (resistive dipole chicane system, ESS), ion diagnostics and shaping, online dosimetry, and in-air sample irradiation end-station for users to enable them to apply laser-driven ion beams in multidisciplinary fields [9,11]. Figure 1.…”

Section: Introductionmentioning

confidence: 99%

“…Figure 1. The main sections of the ELI multidisciplinary applications of laser-ion acceleration (ELIMAIA) beamline (ion accelerator and ELI medical and multidisciplinary applications (ELIMED)) consist of different subsystems: acceleration, collection, and diagnostics; selection, transport, and diagnostics; and dosimetry and sample irradiation [9].…”

Section: Introductionmentioning

confidence: 99%

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Diagnostics and Dosimetry Solutions for Multidisciplinary Applications at the ELIMAIA Beamline

et al. 2018

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ELI (Extreme Light Infrastructure) multidisciplinary applications of laser-ion acceleration (ELIMAIA) is one the user facilities beamlines of the ELI-Beamlines facility in Prague. It will be dedicated to the transport of laser-driven ion beams and equipped with detectors for diagnostics and dosimetry, in order to carry out experiments for a broad range of multidisciplinary applications. One of the aims of the beamline is also to demonstrate the feasibility of these peculiar beams for possible medical applications, which means delivering controllable and stable beams, properly monitoring their transport parameters and accurately measuring the dose per shot. To fulfil this task, innovative systems of charged particle beam diagnostics have been realized and alternative approaches for relative and absolute dosimetry have been proposed. Concerning the first one, real-time diagnostic solutions have been adopted, involving the use of time-of-flight techniques and Thomson parabola spectrometry for an on-line characterization of the ion beam parameters, as well as radiochromic films, nuclear track detectors (typically CR39), and image plates for single shot measurements. For beam dosimetry, real-time beam/dose monitoring detectors have been realized, like the secondary emission monitor and a double-gap ionization chamber, which can be cross calibrated against a Faraday cup, used for absolute dosimetry. The main features of these detectors are reported in this work together with a description of their working principle and some preliminary tests.

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Laser‐driven radiation: Biomarkers for molecular imaging of high dose‐rate effects

et al. 2019

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Recently developed short‐pulsed laser sources garner high dose‐rate beams such as energetic ions and electrons, x rays, and gamma rays. The biological effects of laser‐generated ion beams observed in recent studies are different from those triggered by radiation generated using classical accelerators or sources, and this difference can be used to develop new strategies for cancer radiotherapy. High‐power lasers can now deliver particles in doses of up to several Gy within nanoseconds. The fast interaction of laser‐generated particles with cells alters cell viability via distinct molecular pathways compared to traditional, prolonged radiation exposure. The emerging consensus of recent literature is that the differences are due to the timescales on which reactive molecules are generated and persist, in various forms. Suitable molecular markers have to be adopted to monitor radiation effects, addressing relevant endogenous molecules that are accessible for investigation by noninvasive procedures and enable translation to clinical imaging. High sensitivity has to be attained for imaging molecular biomarkers in cells and in vivo to follow radiation‐induced functional changes. Signal‐enhanced MRI biomarkers enriched with stable magnetic nuclear isotopes can be used to monitor radiation effects, as demonstrated recently by the use of dynamic nuclear polarization (DNP) for biomolecular observations in vivo. In this context, nanoparticles can also be used as radiation enhancers or biomarker carriers. The radiobiology‐relevant features of high dose‐rate secondary radiation generated using high‐power lasers and the importance of noninvasive biomarkers for real‐time monitoring the biological effects of radiation early on during radiation pulse sequences are discussed.

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ELIMAIA: A Laser-Driven Ion Accelerator for Multidisciplinary Applications

Cited by 58 publications

References 59 publications

Shaping of a laser-accelerated proton beam for radiobiology applications via genetic algorithm

Shaping of a laser-accelerated proton beam for radiobiology applications via genetic algorithm

Diagnostics and Dosimetry Solutions for Multidisciplinary Applications at the ELIMAIA Beamline

Laser‐driven radiation: Biomarkers for molecular imaging of high dose‐rate effects

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