Elicited Antibodies in Baboons Exposed to Tissues from ??1,3-Galactosyltransferase Gene-Knockout Pigs

Tseng, Yau‐Lin; Moran, Kathleen; Dor, Frank J. M. F.; Sanderson, Todd M.; Li, Wei; Lancos, Courtney J.; Schuurman, Henk Jan; Sachs, David H.; Cooper, D. K. C.

doi:10.1097/01.tp.0000197555.16093.98

Cited by 37 publications

(29 citation statements)

References 22 publications

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“…Transplantation of porcine hearts from α(1,3)-galactosyltransferase knockout pigs has increased graft survival over previous studies [42]. However, anti-non Gal antibodies (which induce delayed xenograft rejection) did develop in baboons receiving the transplanted porcine hearts within several weeks following transplantation [43]. Thus, the first steps have been made to successfully combat HAR, although hyperacute rejection and delayed rejection cannot be completely ablated using this approach.…”

Section: Advances In Xenotransplantation Of Porcine Tissuesmentioning

confidence: 94%

Porcine Embryonic Stem Cells: A Possible Source for Cell Replacement Therapy

Hall

2008

Stem Cell Rev

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The development of porcine embryonic stem cell lines (pESC) has received renewed interest given the advances being made in the production of immunocompatible transgenic pigs. However, difficulties are evident in the production of pESCs in-vitro. This may largely be attributable to differences in porcine pre-implantation development compared to the mouse and human. Expression of oct4, nanog and sox2 differs in the zona-enclosed porcine blastocyst compared to its mouse and human counterparts, which may suggest that other factors may be responsible for maintaining porcine pluripotency in the early blastocyst. In addition, the epiblast forms considerably later, at days 7 to 8 when the porcine blastocyst begins to hatch and is maintained for 4 days before completely differentiating. This review covers an outline of the known molecular profile during porcine pre-implantation development and provides a history in the development of putative pESCs to date. Greater knowledge on the molecular mechanisms that underlie porcine pluripotency and pre-implantation development may aid in improving the development of pESCs.

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Section: Advances In Xenotransplantation Of Porcine Tissuesmentioning

confidence: 94%

Porcine Embryonic Stem Cells: A Possible Source for Cell Replacement Therapy

Hall

2008

Stem Cell Rev

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“…Co-stimulation blockade in the Kuwaki study appeared to be more effective at preventing the non-Gal humoral response than in the accompanying kidney xenograft study [6 ], because elicited circulating non-Gal antibodies were only detected after graftectomy and cessation of treatment [10]. Nevertheless the Gal KO hearts were still rejected, and it was suggested that activation of graft endothelium by low levels of non-Gal antibodies was at least partly responsible [10].…”

Section: Introductionmentioning

confidence: 98%

Molecular regulation of xenoreactivity

Cowan

Nottle²,

d’Apice³

2007

Current Opinion in Organ Transplantation

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“…The cytotoxicity of AGAB is due in part to the high abundance of the preformed antibody, its strong induction posttransplant, and the abundance of the Gal antigen on a diverse set of glycolipids and glycoproteins. In contrast, non-Gal antibody and antigens seem to be much less abundant (23) and may be predominantly EC proteins (24), although additional carbohydrate antigens may yet be defined (25). These differences suggested that the elimination of the Gal antigen (group 3) might significantly alter the histopathology or tempo of xenograft rejection.…”

Section: Discussionmentioning

confidence: 87%