Elicitation of isoflavonoids in Colombian edible legume plants with jasmonates and structurally related compounds

Gómez, Karen; Quenguan, Franklin; Aristizábal, D.; Escobar, Gustavo; Quiñones, Winston; García‐Beltrán, Olimpo; Durango, Diego

doi:10.1016/j.heliyon.2022.e08979

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…Punica granatum elicited with 200 μM MJ displayed an increased accumulation of flavonols and phenols ( Chang et al, 2021 ). Bean varieties such as Phaseolus vulgaris , Glycine max , and Vigna radiata demonstrated a higher accumulation of isoflavanoids on MJ treatment ( Gómez et al, 2022 ).…”

Section: Elicitation Of Secondary Metabolites Using Jasmonatesmentioning

confidence: 99%

Jasmonates in plant growth and development and elicitation of secondary metabolites: An updated overview

et al. 2022

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Secondary metabolites are incontestably key specialized molecules with proven health-promoting effects on human beings. Naturally synthesized secondary metabolites are considered an important source of pharmaceuticals, food additives, cosmetics, flavors, etc., Therefore, enhancing the biosynthesis of these relevant metabolites by maintaining natural authenticity is getting more attention. The application of exogenous jasmonates (JAs) is well recognized for its ability to trigger plant growth and development. JAs have a large spectrum of action that covers seed germination, hypocotyl growth regulation, root elongation, petal expansion, and apical hook growth. This hormone is considered as one of the key regulators of the plant’s growth and development when the plant is under biotic or abiotic stress. The JAs regulate signal transduction through cross-talking with other genes in plants and thereby deploy an appropriate metabolism in the normal or stressed conditions. It has also been found to be an effective chemical elicitor for the synthesis of naturally occurring secondary metabolites. This review discusses the significance of JAs in the growth and development of plants and the successful outcomes of jasmonate-driven elicitation of secondary metabolites including flavonoids, anthraquinones, anthocyanin, xanthonoid, and more from various plant species. However, as the enhancement of these metabolites is essentially measured via in vitro cell culture or foliar spray, the large-scale production is significantly limited. Recent advancements in the plant cell culture technology lay the possibilities for the large-scale manufacturing of plant-derived secondary metabolites. With the insights about the genetic background of the metabolite biosynthetic pathway, synthetic biology also appears to be a potential avenue for accelerating their production. This review, therefore, also discussed the potential manoeuvres that can be deployed to synthesis plant secondary metabolites at the large-scale using plant cell, tissue, and organ cultures.

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Section: Elicitation Of Secondary Metabolites Using Jasmonatesmentioning

confidence: 99%

Jasmonates in plant growth and development and elicitation of secondary metabolites: An updated overview

et al. 2022

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“…Jasmonates, such as JA and MeJA, can trigger secondary metabolic pathways in plants, resulting in an arsenal of antimicrobial bioactive metabolites (such as isoflavonoids and volatile compounds) with diverse structures and preceding biochemical pathways [43]. Since COR mimics (+)-7-iso-jasmonoyl-L-isoleucine, it has been used as a tool to design synthetic structural analogs that can be used as stimulators of plant defense mechanisms in agriculture [44]. COR reduces the production of ROS by activating antioxidant enzymes and 2,2-diphenyl-1-picrylhydrazyl (DPPH)-radical scavenging, thereby preventing membrane peroxidation and denaturation of biomolecules under salinity stress in cotton [45], and it can enhance cabbage seedlings' resistance to black rot, which might be related to the variation of antioxidant enzyme activity, the O 2generation rate, or MDA content after 1 µg/mL COR application [22].…”

Section: Discussionmentioning

confidence: 99%

Coronatine-Induced Maize Defense against Gibberella Stalk Rot by Activating Antioxidants and Phytohormone Signaling

Liu,

Sui,

et al. 2023

JoF

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One of the most destructive diseases, Gibberella stalk rot (GSR), caused by Fusarium graminearum, reduces maize yields significantly. An induced resistance response is a potent and cost-effective plant defense against pathogen attack. The functional counterpart of JAs, coronatine (COR), has attracted a lot of interest recently due to its ability to control plant growth and stimulate secondary metabolism. Although several studies have focused on COR as a plant immune elicitor to improve plant resistance to pathogens, the effectiveness and underlying mechanisms of the suppressive ability against COR to F. graminearum in maize have been limited. We investigated the potential physiological and molecular mechanisms of COR in modulating maize resistance to F. graminearum. COR treatment strongly enhanced disease resistance and promoted stomatal closure with H2O2 accumulation, and 10 μg/mL was confirmed as the best concentration. COR treatment increased defense-related enzyme activity and decreased the malondialdehyde content with enhanced antioxidant enzyme activity. To identify candidate resistance genes and gain insight into the molecular mechanism of GSR resistance associated with COR, we integrated transcriptomic and metabolomic data to systemically explore the defense mechanisms of COR, and multiple hub genes were pinpointed using weighted gene correlation network analysis (WGCNA). We discovered 6 significant modules containing 10 candidate genes: WRKY transcription factor (LOC100279570), calcium-binding protein (LOC100382070), NBR1-like protein (LOC100275089), amino acid permease (LOC100382244), glutathione S-transferase (LOC541830), HXXXD-type acyl-transferase (LOC100191608), prolin-rich extensin-like receptor protein kinase (LOC100501564), AP2-like ethylene-responsive transcription factor (LOC100384380), basic leucine zipper (LOC100275351), and glycosyltransferase (LOC606486), which are highly correlated with the jasmonic acid–ethylene signaling pathway and antioxidants. In addition, a core set of metabolites, including alpha-linolenic acid metabolism and flavonoids biosynthesis linked to the hub genes, were identified. Taken together, our research revealed differentially expressed key genes and metabolites, as well as co-expression networks, associated with COR treatment of maize stems after F. graminearum infection. In addition, COR-treated maize had higher JA (JA-Ile and Me-JA) levels. We postulated that COR plays a positive role in maize resistance to F. graminearum by regulating antioxidant levels and the JA signaling pathway, and the flavonoid biosynthesis pathway is also involved in the resistance response against GSR.

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“…Although they only have a modest range among plants, they are primarily found in the leguminous family. Globally, the prime dietary origin of isofavones is mung bean, common bean, and soybean [21]. Black peas and green beans both contain certain isofavones, including daidzein, genistein, and glycitein, in very small amounts.…”

Section: Flavonolsmentioning

confidence: 99%

A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

Gajender

Mazumder

Sharma

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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The liver is a crucial organ that is involved in various kinds of metabolic activity and a very stable accessory gland for the digestive system. Long-term or persistent inflammation and oxidative stress due to any reasons have a substantial impact on the beginning and continuation of chronic diseases such as hepatocellular carcinoma, liver cirrhosis, liver fibrosis, and other hepatic conditions. There are many sources which can help the liver to be healthy and enhance its metabolic potential of the liver. Since the diet is rich origin of bioactive along with antioxidant chemicals including flavonoids and polyphenols, it can control different stages of inflammation and hepatic diseases. Numerous food sources, notably vegetables, nuts, fruits, cereals, beverages, and herbal medicinal plants, are rich in bioactive chemicals called flavonoids and their derivatives like Flavones, Anthocyanins, Iso-flavonoid, Flavanones, Flavanols, and Flavan-3-ols. Most recently occurred research on flavonoids has demonstrated that they can regulate hepatoprotective properties. This is because they are essential parts of pharmaceutical and nutraceutical products due to their hepatoprotective, antioxidative, and immune-modulating characteristics. However, the characteristics of their hepatoprotective impact remain unclear. The purpose of this comprehensive review is to survey the flavonoid structure and enriched sources for their hepatoprotective and antioxidant effects concerning liver toxicity or injury.

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Elicitation of isoflavonoids in Colombian edible legume plants with jasmonates and structurally related compounds

Cited by 5 publications

References 26 publications

Jasmonates in plant growth and development and elicitation of secondary metabolites: An updated overview

Jasmonates in plant growth and development and elicitation of secondary metabolites: An updated overview

Coronatine-Induced Maize Defense against Gibberella Stalk Rot by Activating Antioxidants and Phytohormone Signaling

A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

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