Elicitation of 7-methyljuglone in Drosera capensis

Ziaratnia, Seyed Mahdi; Kunert, K.; Lall, Namrita

doi:10.1016/j.sajb.2008.08.001

Cited by 19 publications

(16 citation statements)

References 40 publications

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“…The highest plumbagin level was found in the shoot after adding salicylic acid (100 lM for 6 days (1.1 ± 0.1 mg/g dry wt), which was double the control. This result is similar to that reported on the stimulation of 7-methyljuglone by salicylic acid in D. capensis (Ziaratnia et al 2009). …”

Section: Resultssupporting

confidence: 92%

“…Methyl jasmonate at 50 lM gave the highest concentration of plumbagin in both the shoot and root (1.4 ± 0.2 and 7.4 ± 0.1 mg/g dry wt, respectively), which was 3-fold higher than the control plants (0.5 and 2.6 ± 0.4 mg/g dry wt, respectively). These results are similar to those of Ziaratnia et al (2009) who showed that 7-methyljuglone (a naphthoquinone) accumulation was induced by jasmonic acid when added to D. capensis in vivo.…”

Section: Resultssupporting

confidence: 91%

“…In a previous study, plumbagin production in D. capensis was enhanced by adding a lysate of Agrobacterium rhizogenes (Krolicka et al 2008). Ziaratnia et al (2009) reported that jasmonic acid and salicylic acid stimulated 7-methyljuglone accumulation in D. capensis. However, no specific elicitor has a general effect on different plant species.…”

Section: Introductionmentioning

confidence: 97%

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Enhanced plumbagin production from in vitro cultures of Drosera burmanii using elicitation

et al. 2010

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 97%

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Enhanced plumbagin production from in vitro cultures of Drosera burmanii using elicitation

et al. 2010

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“…Hook (2001) reported that ramentaceone constituted 0.6% and 0.5% of the DW of in vitro cultured D. rotundifolia and D. capensis, respectively. Ziaratnia et al (2009), however, reported much lower levels of ramentaceone in in vitro cultures of D. capensis, which were estimated at 0.0025% DW. In comparison Babula et al (2006) reported 0.82% DW of the isomer of ramentaceone, plumbagin, in in vitro cultures of Dionaea muscipula and among the examined Drosera sp.…”

Section: Discussionmentioning

confidence: 90%

In vitro cultures of Drosera aliciae as a source of a cytotoxic naphthoquinone: ramentaceone

2011

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A protocol for the in vitro propagation of Drosera aliciae to increase the yield of the naphthoquinone, ramentaceone, was developed. The highest micropropagation coefficient was obtained using half-strength Murashige-Skoog medium supplemented with 0.4 μM 6-benzyladenine (BA). The genetic fidelity and stability of the regenerated plants was confirmed with RAPD markers. The activity of the isolated ramentaceone was determined against four human tumor cell lines: U937, HeLa, MCF-7, HCT-116 with the highest cytotoxic activity towards the leukemic U937 cell line with an IC(50) value of 3.2 μM.

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“…The level of quinones in plants is directly linked to the growth medium. According to the research by Ziaratnia et al (2009), for the production of 7-methyljuglone Murashige and Skoog (MS), half-strength MS or Gamborg B 5 media are advised. The worst result for the tested media was presented in plants grown on 1/3 strength MS medium.…”

Section: Naphthoquinonesmentioning

confidence: 99%

In vitro cultures of carnivorous plants from the Drosera and Dionaea genus for the production of biologically active secondary metabolites

Banasiuk¹,

Kawiak²,

Królicka³

2012

bta

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Carnivorous plants belong to endangered species. Due to agricultural development, natural populations of these plants are diminishing. The herbal and ornamental value of these species has also led to their over-collection.The Drosera genus is a natural source of pharmacologically important compounds (e.g. naphthoquinones, flavonoids, anthocyanins, phenolic compounds) used as substrates in the production of pharmaceuticals. Droserae herba has been in use as an expectorant, diuretic and antispasmodic agent. In recent years, the bacteriostatic and antitumour activity of Drosera extracts has been reported. Carnivorous plants have become an important ornamental element in botanical garden collections. This fact, as well as the low propagation rate in their natural environment, is the reason for the in vitro propagation of carnivorous plants. From a single plant cultivated in vitro many genetically identical clonal lines can be obtained through vegetative propagation. This technique allows for the increase in the propagation rate of valuable plant material. Additionally, the use of biotic and abiotic elicitors increases the synthesis of pharmacologically active compounds (bactericidal, bacteriostatic activity and cytotoxic activity). Elicitors play a significant role in the production of secondary metabolites. They induce defense responses in plants, which leads to the accumulation of secondary metabolites. In some cases, compounds not synthesized normally by plants in their natural environment are produced upon elicitation. Elicitors induce the biosynthesis of enzymes which take part in the production of secondary metabolites.

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Elicitation of 7-methyljuglone in Drosera capensis

Cited by 19 publications

References 40 publications

Enhanced plumbagin production from in vitro cultures of Drosera burmanii using elicitation

Enhanced plumbagin production from in vitro cultures of Drosera burmanii using elicitation

In vitro cultures of Drosera aliciae as a source of a cytotoxic naphthoquinone: ramentaceone

In vitro cultures of carnivorous plants from the Drosera and Dionaea genus for the production of biologically active secondary metabolites

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