Abstract:This study investigated whether Elexacaftor-Tezacaftor-Ivacaftor
(Kaftrio ), a cystic fibrosis (CF) transmembrane
conductance regulator (CFTR) modulator, could improve exercise capacity
in adolescents with CF. After six weeks treatment, Kaftrio
improved both maximal and submaximal indices of
aerobic fitness. Improvements were independent of changes in ventilatory
function during exercise and physical activity. Interestingly, pulmonary
oxygen uptake per unit of power output was higher in two, out of three,
cas… Show more
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