Elevations of inflammatory markers PTX3 and sST2 after resuscitation from cardiac arrest are associated with multiple organ dysfunction syndrome and early death

Ristagno, Giuseppe; Varpula, Tero; Masson, Serge; Greco, Marta; Bottazzi, Barbara; Milani, Valentina; Aleksova, Aneta; Sinagra, Gianfranco; Assandri, Roberto; Tiainen, Marjaana; Vaahersalo, Jukka; Kurola, Jouni; Barlera, Simona; Montanelli, Alessandro; Latini, Roberto; Pettilä, Ville; Bendel, Stepani; Skrifvars, Markus B.

doi:10.1515/cclm-2014-1271

Cited by 23 publications

(36 citation statements)

References 39 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In these patients, PTX3 plasma levels are markedly elevated and are associated with higher risk of multiple organ dysfunction syndrome. 159 Overall, these data indicate that measurement of PTX3 in the course of a systemic inflammatory response may improve patient risk assessment and thus be useful in guiding subsequent therapeutic interventions.…”

Section: Ptx3 As Diagnostic/prognostic Marker During Inflammation Amentioning

confidence: 81%

“…The systemic inflammatory response observed after a condition of total body ischemia and reperfusion is characterized by deregulated cytokines production, presence of endotoxin in plasma and coagulation abnormalities. In these patients, PTX3 plasma levels are markedly elevated and are associated with higher risk of multiple organ dysfunction syndrome . Overall, these data indicate that measurement of PTX3 in the course of a systemic inflammatory response may improve patient risk assessment and thus be useful in guiding subsequent therapeutic interventions.…”

Section: Ptx3 As Diagnostic/prognostic Marker During Inflammation Andmentioning

confidence: 83%

See 1 more Smart Citation

Pentraxins in the activation and regulation of innate immunity

Daigo

Inforzato

Barajon

et al. 2016

Immunological Reviews

Self Cite

View full text Add to dashboard Cite

Humoral fluid phase pattern recognition molecules (PRMs) are a key component of the activation and regulation of innate immunity. Humoral PRMs are diverse. We focused on the long pentraxin PTX3 as a paradigmatic example of fluid phase PRMs. PTX3 acts as a functional ancestor of antibodies and plays a non-redundant role in resistance against selected microbes in mouse and man and in the regulation of inflammation. This molecule interacts with complement components, thus modulating complement activation. In particular PTX3 regulates complement-driven macrophage-mediated tumor progression, acting as an extrinsic oncosuppressor in preclinical models and selected human tumors. Evidence collected over the years suggests that PTX3 is a biomarker and potential therapeutic agent in humans, and pave the way to translation of this molecule into the clinic.

show abstract

Section: Ptx3 As Diagnostic/prognostic Marker During Inflammation Amentioning

confidence: 81%

Section: Ptx3 As Diagnostic/prognostic Marker During Inflammation Andmentioning

confidence: 83%

Pentraxins in the activation and regulation of innate immunity

Daigo

Inforzato

Barajon

et al. 2016

Immunological Reviews

Self Cite

View full text Add to dashboard Cite

show abstract

“…In conditions of total body ischemia and reperfusion, the systemic inflammatory response is characterized by the presence of endotoxin in plasma, deregulation of cytokine production and coagulation defects. In these situations, PTX3 expression in plasma increases and is associated with an enhanced risk of multiple organ dysfunction syndrome …”

Section: Clinical Translation As a Biomarker Of Tissue And Vascular Dmentioning

confidence: 99%

“…Of note, PTX3 has been demonstrated to be the only independent predictor of mortality within 3 months from the event . In addition, PTX3 levels reveal atherosclerosis and have been associated with disease severity and mortality in heart failure, stroke and upon resuscitation from cardiac arrest …”

Section: Clinical Translation As a Biomarker Of Tissue And Vascular Dmentioning

confidence: 99%

The long pentraxin PTX3: A prototypical sensor of tissue injury and a regulator of homeostasis

Erreni

Manfredi

Garlanda

et al. 2017

Immunological Reviews

View full text Add to dashboard Cite

Tissue damage frequently occurs. The immune system senses it and enforces homeostatic responses that lead to regeneration and repair. The synthesis of acute phase molecules is emerging as a crucial event in this program. The prototypic long pentraxin PTX3 orchestrates the recruitment of leukocytes, stabilizes the provisional matrix in order to facilitate leukocyte and stem progenitor cells trafficking, promotes swift and safe clearance of dying cells and of autoantigens, limiting autoimmunity and protecting the vasculature. These non-redundant actions of PTX3 are necessary for the resolution of inflammation. Recent studies have highlighted the mechanisms by which PTX3 adapts the functions of innate immune cells, orchestrates tissue repair and contributes to select the appropriate acquired immune response in various tissues. Conversely, PTX3 continues to be produced in diseases where the inflammatory response does not resolve. It is therefore a valuable biomarker for more precise and personalized stratification of patients, often independently predicting clinical evolution and outcome. There is strong promise for novel therapies based on understanding the mechanisms with which PTX3 plays its homeostatic role, especially in regulating leukocyte migration and the resolution of inflammatory processes.

show abstract

“…Primary pro‐inflammatory signals (bacterial components, pathogen‐associated molecular patterns, damage‐associated molecular patterns, IL‐1, TNF‐alpha) induce the synthesis and release of PTX3 in various cell types such as endothelial cells, polymorphonuclear leucocytes (PMN) and monocytes/macrophages . On account of its specific involvement in the immune system and inflammatory processes, and as it can be measured in blood, PTX3 has been characterized as a biomarker of disease severity and outcomes in different cardiovascular diseases, malignancies and specific infections . Since the first report , several studies have focused on the roles of elevated circulating PTX3 in sepsis and related complications such as shock.…”

Section: Introductionmentioning

confidence: 99%