Elevation red cell distribution width and inflammation in printing workers

Çelik, Ahmet; Aydın, Neriman; Özçırpıcı, Birgül; Sarıcicek, Edibe; Sezen, Hatice; Okumuş, Mehmet; Bozkurt, Selim; Kılınç, Metin

doi:10.12659/msm.889694

Cited by 15 publications

(5 citation statements)

References 37 publications

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“…In recent years, many studies have presented red cell distribution width (RDW) as a strong and independent risk factor for death (6, 7). RDW reflects impaired erythropoiesis and abnormal red blood cell survival, while the heterogeneity of red blood cell size correlates with inflammation and undernutrition status (8–10). Recent studies have also shown that RDW could be a prognostic factor in several carcinomas, including ovarian carcinoma (11), lung carcinoma (12), gastric carcinoma (13), and laryngeal carcinoma (14).…”

Section: Introductionmentioning

confidence: 99%

Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma

Hsueh

Lau

et al. 2019

Front. Oncol.

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Objective: High levels of red cell distribution width (RDW) may be associated with adverse outcomes in patients with cancer. The purpose of the present study was to investigate the prognostic impact of pretreatment RDW levels on overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS) in a large cohort of male laryngeal squamous cell cancer (LSCC) patients. Methods: A total of 809 LSCC patients who were treated between 2007 and 2011 at the Eye & ENT Hospital of Fudan University were enrolled and evaluated retrospectively. OS, CSS, and DFS were analyzed using the Kaplan–Meier method. To evaluate the prognostic significance of RDW levels, univariate, and multivariate Cox analyses were applied. Results: Higher pretreatment RDW levels were significantly associated with high death events, red blood cell count, hemoglobin, radiotherapy, operation therapy, and advanced tumor stage ( p < 0.05). From the univariate analysis, we observed that the higher (13.2–13.5%) and the highest (>13.5%) quartiles of RDW level were consistent factors for poor OS, CSS, and DFS in LSCC patients. In the multivariate analysis, after adjusting for confounding factors, the higher and highest quartiles of RDW levels were identified as independent prognostic factors in male LSCC patients. Conclusion: Higher pretreatment RDW levels were demonstrated to be associated with poor clinical outcome in male LSCC patients and might be novel markers for patient stratification in LSCC management.

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Section: Introductionmentioning

confidence: 99%

Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma

Hsueh

Lau

et al. 2019

Front. Oncol.

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“…However, chronic exposure to toluene and xylene may cause brain and neurobehavioral disorders in workers (8). In addition, there are significant health risks, such as dermatitis, cancers, neurological damage, as well as liver and renal impairments, that are associated with solvents and other chemicals and need to be considered in the printing industry (9).…”

Section: Introductionmentioning

confidence: 99%

Quantification of Urinary Metabolites of Toluene and Xylene Isomers as Biological Indices of Occupational Exposure in Printing Industry Workers

et al. 2019

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Background:In the printing industry, workers are occupationally exposed to an extensive variety of chemical solvents, including toluene and xylene. Biological monitoring is an essential tool for assessing occupational health risk. Objectives: The aim of the present study was to evaluate occupational exposure to toluene and xylene, as well as the biomarkers of exposure, in workers of the printing industry. Methods: The hippuric acid (HA) and o-, m-and p-methyl hippuric acids (o-, m-, p-MHAs) as the biomarkers of occupational exposure to toluene and each of the three xylene isomers, respectively, were determined in the urine samples of 84 subjects, including 44 printing workers and 40 non-exposed subjects. Results:The mean concentrations of toluene (37.64 ± 24.09 ppm) in the breathing zone of workers were higher, and the mean level of each of the three isomers of xylene (o-, m-, and p-xylene) was less than the American Conference of Governmental Industrial Hygienists (ACGIH) threshold limit values (TLVs). In addition, the levels of urinary HA, o-MHA, and m-and p-MHA in the exposed group were 0.15 ± 0.04, 0.11 ± 0.01, and 0.19 ± 0.07 g g -1 creatinine, respectively. Printing workers showed a significant increase in the levels of urinary HA compared to the non-exposed subjects (P < 0.001). The correlation analysis demonstrated significant correlations between the intensity of the occupational exposure to toluene and xylene and the level of exposure biomarkers in the urine. Conclusions: The results indicated that although all the urinary biomarkers of exposure were below the Biological Exposure Indices (BEIs) recommended by ACGIH, the levels of the urinary metabolites of toluene and xylene were increased in printing workers. Therefore, monitoring of occupational exposure to toluene and xylene is helpful in the following-up of affected workers in the printing industry.

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“…Xylene is a carcinogen and also associated with central nervous system abnormities such as brain and neurobehavioral morbidities [71,72]. In our study, the positive association between personal total BTEX and DBP was mostly driven by o-xylene, while no adverse associations between BMA (marker of toluene exposure) and vascular endpoints were observed.…”

Section: Discussionmentioning

confidence: 42%

Personal NO2 and Volatile Organic Compounds Exposure Levels are Associated with Markers of Cardiovascular Risk in Women in the Cape Town Region of South Africa

Everson

Boever

Nawrot

et al. 2019

IJERPH

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Exposure to ambient NO2 and benzene, toluene ethyl-benzene and m+p- and o-xylenes (BTEX) is associated with adverse cardiovascular effects, but limited information is available on the effects of personal exposure to these compounds in South African populations. This 6-month follow-up study aims to determine 7-day personal ambient NO2 and BTEX exposure levels via compact passive diffusion samplers in female participants from Cape Town, and investigate whether exposure levels are associated with cardiovascular risk markers. Overall, the measured air pollutant exposure levels were lower compared to international standards. NO2 was positively associated with systolic and diastolic blood pressure (SBP and DBP), and inversely associated with the central retinal venular equivalent (CRVE) and mean baseline brachial artery diameter. o-xylene was associated with DBP and benzene was strongly associated with carotid intima media thickness (cIMT). Our findings showed that personal air pollution exposure, even at relatively low levels, was associated with several markers of cardiovascular risk in women residing in the Cape Town region.

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Elevation red cell distribution width and inflammation in printing workers

Cited by 15 publications

References 37 publications

Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma

Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma

Quantification of Urinary Metabolites of Toluene and Xylene Isomers as Biological Indices of Occupational Exposure in Printing Industry Workers

Personal NO2 and Volatile Organic Compounds Exposure Levels are Associated with Markers of Cardiovascular Risk in Women in the Cape Town Region of South Africa

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