1971
DOI: 10.1111/j.0954-6820.1971.tb04340.x
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Elevation of Uric Acid Clearance Caused by Inappropriate Antidiuretic Hormone Secretion

Abstract: Abstract. Two patients with hyponatraemia resulting from an inappropriate ADH secretion syndrome had low serum values and elevated clearances of uric acid. All the values returned to normal after fluid restriction. The same changes in uric acid clearance and serum level were seen when this syndrome was experimentally induced in five normal subjects.

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Cited by 75 publications
(22 citation statements)
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“…We demonstrated the value of determining serum urate levels in hyponatremia and fortified our contention that the persistence of hypouricemia and elevated fractional excretion (FE) of urate after correction of hyponatremia differentiate RSW from SIADH, since the hypouricemia and elevated FEurate in SIADH normalize after correction of the hyponatremia (1,5,(11)(12)(13)(14)(15)(16)(17)(18). Differences in urate metabolism, however, are evident only after correction of the hyponatremia and would not contribute to differentiating SIADH from RSW on first encounter.…”
mentioning
confidence: 65%
See 1 more Smart Citation
“…We demonstrated the value of determining serum urate levels in hyponatremia and fortified our contention that the persistence of hypouricemia and elevated fractional excretion (FE) of urate after correction of hyponatremia differentiate RSW from SIADH, since the hypouricemia and elevated FEurate in SIADH normalize after correction of the hyponatremia (1,5,(11)(12)(13)(14)(15)(16)(17)(18). Differences in urate metabolism, however, are evident only after correction of the hyponatremia and would not contribute to differentiating SIADH from RSW on first encounter.…”
mentioning
confidence: 65%
“…This has been reviewed in our in-depth review of renal urate transport (11). The V1 receptor activity of ADH is untenable because ADH levels are still elevated when FEurate normalizes with the correction of hyponatremia (16,17,18,35) and induction of SIADH by dDAVP increased FEurate without V1 activity (36).…”
Section: Discussionmentioning
confidence: 99%
“…Other factors may also be important. Indirect data suggest that chronicity of hyponatremia affects UA clearance in SIAD by reducing tubular UA reabsorption as a consequence of decreased intracellular anion levels during cell adaptation to hypotonicity (18). Thiazides are also considered to enhance FE-UA by increasing arginine vasopressin (AVP) activity (19,20) or inducing up-regulation of aquaporin-2 expression (21).…”
Section: Discussionmentioning
confidence: 99%
“…Patients with SIADH had hypouricemia and increased FEurate, which normalized after correction of the hyponatremia. (Dorhout Mees et al, 1971) In 1979 Beck duplicated these findings, but compared serum urate in SIADH with other causes of hyponatremia. Except for only one overlapping value, there was complete separation of serum urate in SIADH from other causes of hyponatremia.…”
Section: Emerging Value Of Determining Feuratementioning
confidence: 99%