Elevation of Soluble Adhesion Molecules Is Associated With the Severity of Myocardial Damage in Acute Myocardial Infarction

Li, Yi‐Heng; Teng, Jeng Kai; Tsai, Wei-Chun; Tsai, Liang‐Miin; Lin, Long-Yau; Chen, Jyh-Hong

doi:10.1016/s0002-9149(97)00644-9

Cited by 45 publications

(21 citation statements)

References 14 publications

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“…Plasma ICAM-1 levels have been shown to increase in direct proportion to cardiac damage. 43) In our study, the two groups did not significantly differ in preoperative plasma ICAM-1 levels. However, significantly lower plasma ICAM-1 levels were observed during surgery and 4 h after surgery among patients undergoing surgery in the morning.…”

Section: Discussioncontrasting

confidence: 41%

The Effect of Circadian Melatonin Levels on Inflammation and Neurocognitive Functions Following Coronary Bypass Surgery

Geyik

Yıgıter

Akcali

et al. 2015

ATCS

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Purpose: In this study, the relationship between the plasma levels of melatonin and intercellular adhesion molecule-1 (ICAM-1), which plays role in several intercellular interactions including inflammatory and immune responses, and early neurocognitive functions associated with ischaemia-reperfusion injury during open heart surgery is examined. Methods: Forty patients who were to undergo elective coronary artery bypass grafting (CABG) were divided into two groups, those who underwent their operations at 8 AM (group I; n = 20) and those who underwent their operations at 1 PM (group II; n = 20). Blood samples were collected prior to surgery (S1), when the aortic cross clamp was removed (S2) and 4 (S3) and 24 h after the surgery (S4). Neuropsychiatric assessment was conducted one day before and seven days after surgery. Results: Melatonin levels measured during and after surgery were also significantly higher in Group 1. ICAM-1 levels were significantly lower in Group 1 at S2 and S3. Significant deterioration was observed in postoperative neurocognitive function compared with preoperative functions in Group 2 more than Group 1. Conclusion: We hypothesise that the greater preservation of neurocognitive functions in the morning patients is associated with elevated melatonin levels, which reduce the damage from ischaemia-reperfusion injury.

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Section: Discussioncontrasting

confidence: 41%

The Effect of Circadian Melatonin Levels on Inflammation and Neurocognitive Functions Following Coronary Bypass Surgery

Geyik

Yıgıter

Akcali

et al. 2015

ATCS

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“…34,35 Moreover, HDL reversed an impaired endothelial function, both in vitro 36 and in vivo. 37 The plasma levels of sICAM-1 and sE-selectin increase in the course of an acute myocardial infarction, 38,39 in which a higher level of adhesion molecules is associated with a larger area of myocardial damage. 39 The present data raise the possibility that increased CAMs expression in the vascular endothelium may be a mechanism by which a low plasma HDL concentration not only promotes atherogenesis but also causes and worsens acute atherothrombotic events.…”

Section: Discussionmentioning

confidence: 99%

“…37 The plasma levels of sICAM-1 and sE-selectin increase in the course of an acute myocardial infarction, 38,39 in which a higher level of adhesion molecules is associated with a larger area of myocardial damage. 39 The present data raise the possibility that increased CAMs expression in the vascular endothelium may be a mechanism by which a low plasma HDL concentration not only promotes atherogenesis but also causes and worsens acute atherothrombotic events. This hypothesis, which would explain the beneficial effects of the current HDL-raising agents in preventing vessels narrowing 40,41 and reducing acute ischemic events, 40,[42][43][44] prompts the development of innovative and specific HDL-based therapies for the prevention and treatment of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Elevated Soluble Cellular Adhesion Molecules in Subjects With Low HDL-Cholesterol

Calabresi

Gomaraschi

Villa

et al. 2002

ATVB

115

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Abstract-The purpose of this study was to investigate whether the expression of cellular adhesion molecules (CAMs) is enhanced in individuals with low HDL cholesterol (HDL-C). Plasma levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1), and E-selectin (sE-selectin) were measured in subjects with low (below the 10th percentile for the Italian population), average, or high (above the 90th percentile) HDL-C. Average sICAM-1 and sE-selectin levels were significantly higher in two groups of 65 individuals with low HDL levels, either hyperlipidemic (320.5Ϯ16.0 and 61.4Ϯ3.5 ng/mL) or normolipidemic (309.6Ϯ13.0 and 60.0Ϯ2.7 ng/mL), than in subjects with average HDL levels, either hyperlipidemic (267.0Ϯ10.1 and 50.4Ϯ2.8 ng/mL) or normolipidemic (257.9Ϯ5.4 and 51.1Ϯ2.4 ng/mL), or with high HDL levels (254.8Ϯ10.2 and 52.5Ϯ3.2 ng/mL). No significant difference was found in the plasma sVCAM-1 concentration. HDL-C was inversely correlated with sICAM-1 and sE-selectin in the low-HDL subjects (r 2 ϭ0.087 and 0.035, Pϭ0.0007 and 0.033, respectively), but not in individuals with normal or elevated HDL-C (r 2 ϭ0.012 and 0.006). A fenofibrate-induced increase of HDL-C in 20 low-HDL subjects was associated with a significant reduction of plasma sICAM-1 and sE-selectin concentrations. An increased CAMs expression may be a mechanism by which a low plasma HDL level promotes atherogenesis and causes acute atherothrombotic events.

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“…Such markers for plaque instability or rupture would establish the diagnosis of ACS at the earliest stage and may predict the onset. Several serum markers, including high-sensitivity C-reactive protein (hs-CRP), 8 oxidized LDL (Ox-LDL), 9 and soluble forms of membrane proteins such as CD40 ligand (CD40L), 10,11 ICAM-1, 12,13 and E-selectin, 12,13 were reported to be associated with ACS or acute myocardial infarction. Although soluble CD40L has recently been shown to be correlated with prognosis after ACS, 14 none of these markers has been established as a diagnostic marker of ACS at the earliest stage.…”

mentioning

confidence: 99%

Serum Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels Are Elevated in Acute Coronary Syndrome

et al. 2005

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Background-Markers of cardiac injury, including troponin-T (TnT), are used to diagnose acute coronary syndrome (ACS); however, markers for plaque instability may be more useful for diagnosing ACS at the earliest stage. Lectin-like oxidized LDL receptor-1 (LOX-1) appears to play crucial roles in the pathogenesis of atherosclerotic plaque rupture and ACS onset. LOX-1 is released in part as soluble LOX-1 (sLOX-1) by proteolytic cleavage. Methods and Results-We examined serum sLOX-1 levels in 521 patients, consisting of 427 consecutive patients undergoing coronary angiography, including 80 ACS patients, 173 symptomatic coronary heart disease patients, 122 patients with significant coronary stenosis without ischemia, and 52 patients without apparent coronary atherosclerosis plus 34 patients with noncardiac acute illness and 60 patients with noncardiac chronic illness. Time-dependent changes in sLOX-1 and TnT levels were analyzed in an additional 40 ACS patients. Serum sLOX-1 levels were significantly higher in ACS than the other groups and were associated with ACS as shown by multivariable logistic regression analyses. Given a cutoff value of 1.0 ng/mL, sLOX-1 can discriminate ACS from other groups with 81% and 75% of sensitivity and specificity, respectively. sLOX-1 can also discriminate ACS without ST elevation or abnormal Q waves and ACS without TnT elevation from non-ACS with 91% and 83% of sensitivity, respectively. Peak values of sLOX-1 in ACS were observed earlier than those of TnT. Conclusions-sLOX-1 appears to be a useful marker for early diagnosis of ACS. (Circulation. 2005;112:812-818.)

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Elevation of Soluble Adhesion Molecules Is Associated With the Severity of Myocardial Damage in Acute Myocardial Infarction

Cited by 45 publications

References 14 publications

The Effect of Circadian Melatonin Levels on Inflammation and Neurocognitive Functions Following Coronary Bypass Surgery

The Effect of Circadian Melatonin Levels on Inflammation and Neurocognitive Functions Following Coronary Bypass Surgery

Elevated Soluble Cellular Adhesion Molecules in Subjects With Low HDL-Cholesterol

Serum Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels Are Elevated in Acute Coronary Syndrome

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