Elevation of Serum Triglyceride Levels from Oral 13-cis-Retinoic Acid

Nigra, Th. P.; Katz, Ronald A.; Jorgensen, Hildegard

doi:10.1007/978-3-642-68023-6_52

Cited by 4 publications

(5 citation statements)

References 22 publications

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“…In a randomized study on former asbestos workers, patients given oral retinol (25,000 IU) have shown a consistent increase of triglyceride levels; from an average of 169 mg/dl at baseline to 212 mg/dl at 2 years [34]. Our results confirm that high-dose vitamin A causes significant increases in serum triglycerides although not of the alarming magnitude observed in patients with preexisting risk factors or hypertrigly ceridemia [32]. The mechanism that leads to the eleva tion of serum lipids is unknown, but it is likely that the genesis of this abnormality is multifactorial, depend ing for its frequency and entity on the kind of drug and the presence of predisposing factors [33].…”

Section: Discussionsupporting

confidence: 79%

“…The correlation between retinoid supplementation or therapy and elevated triglyceride levels has been documented by a number of authors both for natural vitamin A [29,31] and for the synthetic compounds used in dermatology [13,32]. The observed incidence of this side effect varies from 20% with etretinate to 100% in 10 patients receiving 500.000 IU of retinol a day [29.…”

Section: Discussionmentioning

confidence: 99%

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Safety of High-Dose Vitamin A

et al. 1991

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The paper reports on the efficacy and side effects of high-dose vitamin A, administered as adjuvant treatment for resected stage I lung cancer in a randomized clinical trial. After a median follow-up of 28 months, 283 patients were evaluable: 138 allocated to treatment with retinol palmitate (300,000 IU daily for at least 12 months) and 145 to standard observation. The clinical results available to date do well justify a continuation of the study. Skin dryness and desquamation were the most frequent symptoms, affecting 60% of all treated patients. Other symptoms such as dyspepsia, headache, nosebleeds and mild hair loss occurred in less than 10% of patients, and were self-terminating. Only in 4 patients (3%) was the treatment interrupted because of symptoms potentially related to vitamin A administration. As for laboratory tests, Γ-GT levels were abnormally elevated in 69% of treated patients vs. 39% of controls at 24 months (mean 149 vs. 58 IU/1; p < 0.05). Serum triglyceride concentrations over 150mg/dl were seen in 74% of treated patients vs. 43% of controls at 12 months (mean 283 vs. 179mg/dl; p < 0.05). There were no other laboratory signs of toxicity attributable to vitamin A. In our experience, high-dose retinoyl palmitate administration was a well-tolerated and safe treatment. The long-term impact on lipid metabolism still remains to be determined.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Safety of High-Dose Vitamin A

et al. 1991

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“…No long term relationship with cirrhosis or inflammatory bowel disease has been found (35). Hyper‐lipidaemia usually occurs as increased serum triglycerides in 19% and cholesterol in 12%, is proportional to the dosage, and is reversible (16, 39). The greatest increase is seen in the very‐low‐density‐lipoprotein (VLDL) and low‐density‐lipoprotein (LDL) fractions (35, 39).…”

Section: The Criterion For Use Of Isotretinoin In Less Severe Forms Omentioning

confidence: 99%

“…Hyper‐lipidaemia usually occurs as increased serum triglycerides in 19% and cholesterol in 12%, is proportional to the dosage, and is reversible (16, 39). The greatest increase is seen in the very‐low‐density‐lipoprotein (VLDL) and low‐density‐lipoprotein (LDL) fractions (35, 39). There is a decrease in the levels of high‐density‐lipoproteins (HDL) in 20 to 25% of patients (16).…”

Section: The Criterion For Use Of Isotretinoin In Less Severe Forms Omentioning

confidence: 99%

“…There is a decrease in the levels of high‐density‐lipoproteins (HDL) in 20 to 25% of patients (16). A low fat, high carbohydrate diet, reduction of the intake of alcohol and tobacco, increased exercise, and supplementation of fish oils in the diet (35, 39) may help to reduce triglyceride levels. The bone toxicity associated with this drug is outlined below.…”

Section: The Criterion For Use Of Isotretinoin In Less Severe Forms Omentioning

confidence: 99%

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Retinoids: Fascinating Up‐and‐Coming Scenario

Sardana

Sehgal²

2003

The Journal of Dermatology

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Retinoids have been in sharp focus ever since their introduction 30 years ago. They include any drug (s) that bind to retinoid receptors and elicit a biological response. Enormous information on the subject seems to embroil the recent literature. Practically it is impossible to clearly comprehend the undercurrents. The meticulously dispensing text envisages surmounting the perspective reader's predicaments. Accordingly, retinoids and their related facets namely retinoid receptors, classification, mode of action, and the pharmacological diversity have been precisely defined. Commonly used systemic retinoids too have been given a substantial fresh look along with their monitoring. Overall, adverse effects and relative and absolute contraindications have been scrupulously incorporated. Human immuno deficiency virus (HIV) and isoretinoid for acne, in particular, have been highlighted. Micronized isotretinoin formulations have also been taken care so also commonly used topical retinoids. Tretinoin and their newer formulation have also been accounted for along with tretinoin polymer cream. Adapalene, a new chemical entity possessing a unique physico-chemical activity similar to that of tretinoin has also been dealt with. Newer retinoids are likely to be a subject of intrigue. A focus on future potentials of retinoids is its special ingredient. The inclusion of details of rexinoid the most recent introduction in their purview is likely to invoke interest to further consolidate its reckoning in future. All in all the text of the paper should provide an insight into the current rumbling around retinoids.

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